Happy New Year 2024
About us
OPKO Biologics Ltd. (formerly Prolor Biotech), a subsidiary of OPKO Health Inc., is a clinical stage company developing next-generation, bio-better, long-acting versions of therapeutic proteins and peptide drugs, utilizing CTP and reversible PEGylation technologies. The CTP technology involves fusing one or more copies of a naturally occurring glycosylated peptide by rDNA technology to the protein chain ends. When attached to a therapeutic protein, CTP significantly extends its longevity in the body. OPKO Biologics’ second technology is reversible PEGylation, a synthetic chemistry-based platform for enhancing the half-life of therapeutic peptides and small molecules. Using a hydrolysable linker bypasses the disadvantages of using a standard PEGylated molecule, i.e. the potential for steric hindrance that limits its function, and the limited ability to cross cellular membranes or the blood-brain barrier. OPKO Biologics currently presents two bio-better long-acting products: hGH-CTP (Somatrogon, MOD-4023): CTP-modified human growth hormone (hGH). OPKO completed a pivotal Phase 3 study in growth hormone-deficient (GHD) adults and is currently conducting a Phase 3 study in a GHD pediatric population. The company completed a Phase 2 study in GHD adults, demonstrating that a single weekly injection of hGH-CTP could potentially substitute seven consecutive daily injections of regular hGH, and showing an excellent safety profile. OPK88005: CTP-modified long-acting coagulation factor VIIa, potentiality supporting every-other-day prophylactic treatment or twice a week regimen in hemophilia patients. OPK88005 is currently evaluated in an ongoing Phase 2a clinical study.
- Website
-
https://www.opkobiologics.com
External link for OPKO Biologics Ltd.
- Industry
- Biotechnology
- Company size
- 51-200 employees
- Headquarters
- Kiryat Gat, Israel
- Type
- Privately Held
- Founded
- 2001
Locations
-
Primary
16 Ashlegan St.
Kiryat Gat, Israel 8211804, IL
Employees at OPKO Biologics Ltd.
-
Yuval Polonsky
Associate Director USP at OPKO Biologics Ltd.
-
Lea Bardani
Associate Director Records Management at OPKO Biologics Ltd.
-
Gabi Faibish
VP Operations and General Counsel at OPKO Biologics Ltd.
-
Moran Golan
Associate Director Pharmacology and Toxicology at OPKO Biologics Ltd.