Nickelates have been shown to host unconventional superconductivity, and recently it has been found that the choice of substrate can significantly change the superconducting critical temperature. This suggests, that like some Cuprates, strain could be important. Here Gao, Fan, Wang, and coauthors find that magnetic excitations in a parent Nickelate are insensitive to substrate choice, and therefore strain, which differs markedly from the case of Cuprates.

C–H activation in long-chain organic molecules remains largely unexplored. Here, the authors report light-driven C–H activation mediated by 2D TMDCs and the resultant synthesis of luminescent carbon dots.

The Authors use a double modulation of both excitation and emission light to correct aberration and demonstrate imaging through thick scattering tissue. The approach is noise-robust and can image weak fluorescent neurons inside a thick brain slice.

Structural deformation can modify the optical properties of quantum dots. Here, the author report strain-graded CdSe-ZnSe quantum dots, allowing for spectrally stable and pure emission of photons at accelerated rates with near unity luminescence efficiency.

Researchers using femtosecond lasers generate offset-free THz pulses to phase-lock the electronic oscillators. This enables the phase-resolved measurement of the emitted THz pulses with sub-cycle time resolution. Ultrafast dynamic response, such as anti-phase locking behavior, is also observed.

The glaciers of Juneau Icefield, Alaska are reconstructed from 1770 to 2020 AD. Ice loss has accelerated dramatically, with a number of positive feedbacks now happening that accelerate ice loss and inhibit future stabilisation and regrowth.

The authors develop a methodology to quantify climate physical risks, both chronic and acute, on productive assets. Investor losses are underestimated up to 70% when neglecting asset level information, and up to 82% when neglecting tail acute risks.

More atmospheric rivers bringing moisture into the Arctic have been observed in summers of recent decades and have been linked to global warming and Arctic Amplification. In contrast, this study finds that natural forcing relative to large-scale circulation changes is behind this shift.

Exposure to extreme temperatures is a risk to neonatal health and this could be exacerbated by climate change. Here, the authors quantify the relative contribution of climate change to the burden of temperature-related neonatal deaths in 29 low- and-middle-income countries from 2001-2019.

Switching to air-to-air heat pumps in Toulouse cuts energy use and eliminates CO₂ emissions. While efficiency is high, cities transitioning from fossil fuel heating may see increased electricity use, stressing the need for sustainable power sources.

Although single-cell RNA sequencing analysis now allows simultaneous examination of transcriptome and T cell receptor repertoire sequences, integrating these two modalities remains a challenge. Here, the authors develop mvTCR, a generative deep learning model that integrates transcriptome and T cell receptor data into a joint representation capturing cell functions and phenotypes.

Diatoms thrive in dynamic environments that frequently confer high light stress. In this study, the authors report a diatom photoreceptor that triggers immediate transcription of photoprotective genes upon high light signals. The fast response kinetics of this pathway confer advantages in environments with rapid light fluctuations.

Reproducibility is key to all fields of research, and in the case of animal research, this can be hampered by inconsistent reporting of animal genetics. Here the authors propose a reporting framework and guidelines designed to discuss the validation and standardise the reporting of genetic backgrounds and genetic alterations in animal models.

Cryo-EM is an experimental technique for uncovering protein structural and dynamic properties. Here, authors propose a neural network model to infer the structural flexibility of proteins from cryo-EM, demonstrating high accuracy and efficiency.

The study reveals defective maternal mRNA deadenylation in oocytes matured in culture dishes versus natural ones, potentially explaining lower fertility in assisted reproduction with immature oocytes.

Most studies on HIV-1 proviruses that persist during antiretroviral therapy have focused on males with HIV-1 subtype B, even though the majority of people living with HIV globally have non-B subtypes. Here, the authors describe the proviral genetic landscape of HIV-1 subtypes A1 and D in Ugandan females and males using near-full-length proviral sequencing. The authors also describe a molecular assay for intact proviral quantification of these HIV-1 subtypes.

Rapid hemostasis of deep noncompressible irregularly shaped trauma wounds is challenging. Here the authors report a neutrophil extracellular traps (NETs)-inspired DNA hydrogel that is able to induce NETs-like thrombosis as a physical blockade and biological clot to arrest bleeding in deep tissues.

Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes and muscle weakness. Here the authors show that statin-treated female mice show reduced levels of docosahexaenoic acid (DHA) and that the adverse effects are prevented by administering fish oil as a source of DHA, by reducing dosage of the X chromosome or the Kdm5c gene.

Endoplasmic reticulum and inflammatory stress are associated with diabetes. Maestas et al. use single-cell sequencing to profile primary human islets under stress and identified tissue and cell-type responses.

Plasma samples from 324 Black and 1,547 white participants underwent analysis with C2N Diagnostics’ Precivity AD test for Aβ42 and Aβ40. Compared to white individuals, Black individuals had higher average plasma Aβ42/40 levels at baseline, consistent with a lower average level of amyloid pathology.

The authors develop a methodology to quantify climate physical risks, both chronic and acute, on productive assets. Investor losses are underestimated up to 70% when neglecting asset level information, and up to 82% when neglecting tail acute risks.

A European hydrogen infrastructure supports a rapid scale-up of key production centers at Europe’s periphery. However, uncertainties in hydrogen demand, production pathways, and potential imports challenge the network design and storage development.

Recent research shows the existence of outside individual options may hinder group collaboration. Here, the authors show that, when group boundaries are not fixed ex-ante, they facilitate collaboration via the formation of more optimistic groups.

This study on fossil fuel subsidy reforms shows that the share of renewable energy and insulation of political processes from pro-subsidy interests can provide leverage points to break path-dependencies in fossil fuel-based economies.

Developing biotechnologies to address society’s challenges requires integrating concepts across disciplines, posing challenges to educating students with diverse expertise. In this Perspective the authors create a framework for synthetic biology training that deconstructs biotechnologies across spatial scales.