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van der Waals magnets can be arranged into twisted heterostructures, with the twisting leading to the formation of new magnetic phases. Here, Li, Sun, and coauthors show via NVcentre based magnetometry small angle twisted double trilayer CrI3 exhibits a co-existing, hybrid magnetic phase with distinct phase transition temperatures.
Using low-energy photons in light-driven reactions is an effective strategy for improving the efficiency of solar energy conversion but molecular systems that mimic such function are extremely rare in non-noble-metal catalysis. Here the authors report fluorinated chlorins as chromophores for CO2 reduction, which catalytically produce CO under both 630 nm and 730 nm light irradiation.
The heterodimer of METTL1-WDR4 is responsible for adding methylation group to the N7 atom of guanine (m7G) in tRNA molecules. Here the authors show how the tRNA m7G modification mediates tRNA stability to control proteostasis by maintaining efficient protein synthesis, which is important for preventing premature senescence and aging.
Spin shuttling is a promising technique for establishing a quantum link between qubit registers and has been studied in several quantum dot qubit platforms. Here the authors realize coherent shuttling of a hole spin qubit in a minimal quantum dot chain in germanium despite strong spin-orbit coupling.
The authors proposed ClusTric, a temporal stratification approach to find disease progression groups. Applied to Amyotrophic Lateral Sclerosis, the method identifies four progression groups with distinguished characteristics.
Anderson localization is a linear phenomenon, with ongoing debate about the impact of nonlinearity. This study shows that nonlinearity strengthens the localization of surface-gravity waves in a canal with a random bottom through experimental measurements and numerical simulations.
Haematopoietic stem cells (HSCs) rely on tightly controlled protein translation to sustain blood production and respond to stress. Here, the authors uncover that TRMT6-TRMT61A proteins regulate HSC function by modifying tRNA, which fine-tunes mTORC1 signaling and thus translation.
Understanding of artificial neural networks function, and their ability to effectively solve specific tasks, still require more rigorous analytical background. Using network science and dynamical systems tools, the authors develop a framework for predicting the performance of artificial neural networks
Investigating metabolic disturbances in coronary artery disease (CAD) may allow the identifications of new prognostic biomarkers. Here the authors perform a metabolomics study to highlight the shared and distinct metabolites characterizing risks of several cardiovascular events in CAD patients.
Using donor-acceptor bulk heterojunction as sensitiser for efficient charge generation and low charge recombination in triplet-triplet annihilation upconversion, Bi et al report solid-state one-step printed device with upconversion efficiency of 2.2% and threshold excitation intensity of 10 mW cm−2.
Dynamic ocean feedbacks between biological activity, chelating ligand levels, and dissolved iron availability may reverse carbon uptake or outgassing in response to changes in meridional overturning circulation, fundamentally impacting climate.
Here the authors show that the catalytic inhibition of the Top2 complex in interphase has an effect on the stability of heterochromatin and repetitive DNA elements.
Genetic code expansion enables precisely introducing chemical structures into proteins to improve their catalytic functions. In this study, the authors report the incorporation of genetically encoded Nδ-Vinyl Histidine (δVin-H) into an organocatalytic esterase and myoglobin, and improve the performance of the hydrolysis reaction and carbene transfer reactions catalyzed by the respective enzymes.
Single-atom nanozymes are a type of non-protein artificial enzymes and promising for mimicking enzyme active centers, but lack recognition sites to confer substrate specificity. Here, the authors report on a metal-ligand dual-site single-atom nanozyme (Ni-DAB) that mimics the dual-site catalytic mechanism of urate oxidase and has high selectivity in uric acid (UA) oxidation.
Explaining predictions for drug repositioning with biological knowledge graphs is a challenging problem. Here, the authors present an approach for automated biological evidence generation and show strong correlation between extracted paths and derived transcriptional changes of genes and pathways for predictions of Sulindac and Ibudilast in FragileX.
Profiling of single mammalian cells has revolutionized our understanding of complex biological processes. Here, the authors describe a novel mass spectrometry-based sample preparation and acquisition strategy to deeply characterize the proteome at single cell resolution.
Angelman syndrome is a neurodevelopmental disorder caused by the deletion of a single gene. Here, researchers discovered a small molecule that could be delivered peripherally to activate a dormant copy of the gene throughout the brain, providing a potential treatment opportunity.
Both T cells and lung macrophages are involved in the control of lung tuberculosis infection. Here the authors examine the dependence of the lung macrophage response upon the presence of T cells and show that CD4 and CD8 T cells promote the elimination of M.Tb in alveolar macrophages but have less impact on monocyte-derived macrophages.