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The coagulation system is composed of cells, proteins and processes that mediate blood clotting. Damage to a blood vessel wall triggers the system, initiating interactions between platelets and blood coagulation factors. This leads to the formation of a fibrin-containing clot, which stops bleeding and initiates vessel repair.
A spaceflight study shows that Nrf2 contributes to the maintenance of the immune system during spaceflight and suggests that improving the level of baseline Nrf2 activity alleviates the degree of immune suppression during spaceflight.
Current methods for auto-transfusion often result in disturbances to the patient’s blood homeostasis, leading to an increased bleeding risk. Here, the authors develop heparin-mimicking self-anticoagulant sponges for safe and convenient whole blood auto-transfusion, and study underlying mechanisms.
This Perspective provides a concise overview of the diverse functions of vitamin K in physiology and metabolism, including its recently discovered role in ferroptosis.
Extravasation of blood into the brain and activation of innate immune cells are hallmarks and therapeutic targets in neurological diseases. We show that specific blood proteins induce distinct receptor-mediated gene programs in microglia and that the blood coagulation protein fibrin has a causal role in pathogenic innate immunity in models of neurological diseases.
Preserving hemostasis while preventing pathological thrombosis has been a central goal in drug development. A new way to restore hemostasis is suggested by the finding that glycoprotein V is cleaved by thrombin on activated platelets, negatively regulating clotting at sites of vascular injury.
Thrombosis complicates SARS-CoV-2 infection and vaccination. Recent data are being used to identify the autoimmune antibody repertoires responsible for the excessive activation of coagulation and platelets.