![Black figure in bottom right looking through telescope at night sky made of colourful cells instead of stars](https://cdn.statically.io/img/media.springernature.com/w735h400/nature-cms/uploads/cms/pages/6743/top_item_image/Genet_Hero_Oct_21-0b4318460dde35e453969d6ac5925563.jpg)
Spatial omics profiling technologies
Emerging spatial omics methods enable the charting of cellular heterogeneity, complex tissue architectures and dynamic changes during development and disease
Emerging spatial omics methods enable the charting of cellular heterogeneity, complex tissue architectures and dynamic changes during development and disease
Single-cell, spatial and multi-omic profiling technologies generate large-scale data that reveal the output of genome-scale experiments across diverse cells, tissues and organisms. Cole Trapnell reviews the underlying core statistical challenges that need to be tackled to harness the power of these technologies and advance our understanding of gene function in health and disease.