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Articles by Tamas
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From Lab to Clinic: Cyclodextrins and Stargardt Disease Research
From Lab to Clinic: Cyclodextrins and Stargardt Disease Research
By Tamas Sohajda
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Cyclodextrins as actives - the origins from 1983
Cyclodextrins as actives - the origins from 1983
By Tamas Sohajda
Contributions
Activity
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Thank you Healio and Anat Galor for the Licaminlimab article and continuous support in revolutionizing Dry Eye patient treatment through precision…
Thank you Healio and Anat Galor for the Licaminlimab article and continuous support in revolutionizing Dry Eye patient treatment through precision…
Liked by Tamas Sohajda
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Prof Takashi Hayashita presenting an excellent talk at the 6th IC3EM 2024 - as Keynote speaker “Supramolecular Cyclodextrin Complex Sensors for…
Prof Takashi Hayashita presenting an excellent talk at the 6th IC3EM 2024 - as Keynote speaker “Supramolecular Cyclodextrin Complex Sensors for…
Liked by Tamas Sohajda
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Building on our previous work published in ACS Catalysis (2020), I'm thrilled to announce the publication of a follow-up study in Organic Letters…
Building on our previous work published in ACS Catalysis (2020), I'm thrilled to announce the publication of a follow-up study in Organic Letters…
Liked by Tamas Sohajda
Experience & Education
Publications
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Synthesis of modified cyclic and acyclic dextrins and comparison of their complexation ability
Beilstein J. Org. Chem. 2014, 10, 2836–2843; DOI: 10.3762/bjoc.10.301
Abstract
We compared the complex forming ability of α-, β- and γ-cyclodextrins (α-CD, β-CD and γ-CD) with their open ring analogs. In addition to the native cyclodextrins also modified cyclodextrins and the corresponding maltooligomers, functionalized with neutral 2-hydroxypropyl moieties, were synthesized. A new synthetic route was worked out via bromination, benzylation, deacetylation and debenzylation to obtain the 2-hydroxypropyl maltooligomer counterparts. The complexation…Abstract
We compared the complex forming ability of α-, β- and γ-cyclodextrins (α-CD, β-CD and γ-CD) with their open ring analogs. In addition to the native cyclodextrins also modified cyclodextrins and the corresponding maltooligomers, functionalized with neutral 2-hydroxypropyl moieties, were synthesized. A new synthetic route was worked out via bromination, benzylation, deacetylation and debenzylation to obtain the 2-hydroxypropyl maltooligomer counterparts. The complexation properties of non-modified and modified cyclic and acyclic dextrins were studied and compared by photon correlation spectroscopy (PCS) and capillary electrophoresis (CE) using model guest compounds. In some cases cyclodextrins and their open-ring analogs (acyclodextrins) show similar complexation abilities, while with other guests considerably different behavior was observed depending on the molecular dimensions and chemical characteristics of the guests. This was explained by the enhanced flexibility of the non-closed rings. Even the signs of enantiorecognition were observed for the chloropheniramine/hydroxypropyl maltohexaose system. Further studies are planned to help the deeper understanding of the interactions.Other authorsSee publication -
Synthetic strategies for the fluorescent labeling of epichlorohydrin-branched cyclodextrin polymers
Beilstein J. Org. Chem. 2014, 10, 3007–3018; doi:10.3762/bjoc.10.319
Abstract
The fluorescent tagging of cyclodextrin derivatives enlarges their spectroscopic properties thus generating chemosensors, biological tools for visualization and sophisticated photoresponsive devices. Cyclodextrin polymers, due to the cooperative interactions, exhibit additional properties compared to their monomeric counterpart. These macromolecules can be prepared either in well water-soluble form or as gels of high swelling. Two versatile synthetic strategies for introducing a…Abstract
The fluorescent tagging of cyclodextrin derivatives enlarges their spectroscopic properties thus generating chemosensors, biological tools for visualization and sophisticated photoresponsive devices. Cyclodextrin polymers, due to the cooperative interactions, exhibit additional properties compared to their monomeric counterpart. These macromolecules can be prepared either in well water-soluble form or as gels of high swelling. Two versatile synthetic strategies for introducing a fluorescent tag (rhodamine, fluorescein, nitrobenzofuran or coumarin) into the water-soluble epichlorohydrin branched cyclodextrin polymers were worked out and compared. The fluorescent labeling was realized in three steps: 1) building in azido moieties, 2) transforming the azido groups into amino groups and 3) coupling the proper fluorescent compound to the amino groups. The other strategy started by functionalization of the monomer prior to the branching. Either the fluorescent-labeled monomer or the intermediate azido derivative of the monomer was branched. Further tuning of the properties of the polymer was achieved via branching of the methylated cyclodextrin derivative. The key intermediates and the fluorescent final products were characterized by various spectroscopic techniques and capillary electrophoresis. The applied synthetic routes were evaluated based on the molecular weight, cyclodextrin content of the products and the efficiency of labeling.Other authorsSee publication -
Chiral recognition of dapoxetine enantiomers with methylated-gamma-cyclodextrin: A validated capillary electrophoresis method
Journal of Pharmaceutical and Biomedical Analysis
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Separation and characterization of modified pregabalins in terms of cyclodextrin complexation, using capillary electrophoresis and nuclear magnetic resonance
Journal of Pharmaceutical and Biomedical Analysis
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Separation of vinca alkaloid enantiomers by capillary electrophoresis applying cyclodextrin derivatives and characterization of cyclodextrin complexes by nuclear magnetic resonance spectroscopy
Journal of Pharmaceutical and Biomedical Analysis
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Characterization of aspartame–cyclodextrin complexation
Journal of Pharmaceutical and Biomedical Analysis
Languages
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English
Full professional proficiency
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German
Limited working proficiency
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Hungarian
Native or bilingual proficiency
More activity by Tamas
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I am pleased to share our new paper 'Delivery of minoxidil encapsulated in cyclodextrins with photoacoustic waves enhances hair growth' published in…
I am pleased to share our new paper 'Delivery of minoxidil encapsulated in cyclodextrins with photoacoustic waves enhances hair growth' published in…
Liked by Tamas Sohajda
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Dual encapsulation and sequential release of cisplatin and vitamin E from soy polysaccharides and β-cyclodextrin bioadhesive hydrogel nanoparticles
Dual encapsulation and sequential release of cisplatin and vitamin E from soy polysaccharides and β-cyclodextrin bioadhesive hydrogel nanoparticles
Liked by Tamas Sohajda
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Muito grato ao professor #Rilton Alves de Freitas e seu grupo de pesquisa #biopol da Universidade Federal do Paraná UFPR, pelo convite para ministrar…
Muito grato ao professor #Rilton Alves de Freitas e seu grupo de pesquisa #biopol da Universidade Federal do Paraná UFPR, pelo convite para ministrar…
Liked by Tamas Sohajda
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#InCaseYouMissedIt: We recently achieved a landmark milestone with the completion of enrollment of last patient in our Phase 3 Pivotal TransportNPC™…
#InCaseYouMissedIt: We recently achieved a landmark milestone with the completion of enrollment of last patient in our Phase 3 Pivotal TransportNPC™…
Liked by Tamas Sohajda
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I am excited to annonounce my new role as Medical Affairs Lead for Craniometrix. Craniometrix uses highly trained social workers, AI powered…
I am excited to annonounce my new role as Medical Affairs Lead for Craniometrix. Craniometrix uses highly trained social workers, AI powered…
Liked by Tamas Sohajda
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𝗕𝗶𝗼𝗽𝗵𝗮𝗿𝗺𝗮 𝗮𝗰𝗾𝘂𝗶𝘀𝗶𝘁𝗶𝗼𝗻𝘀 𝗛𝟭/𝟮𝟰 Check this superb overview post by Daniel Neumeier, PhD! # of deals and cumulative deal…
𝗕𝗶𝗼𝗽𝗵𝗮𝗿𝗺𝗮 𝗮𝗰𝗾𝘂𝗶𝘀𝗶𝘁𝗶𝗼𝗻𝘀 𝗛𝟭/𝟮𝟰 Check this superb overview post by Daniel Neumeier, PhD! # of deals and cumulative deal…
Liked by Tamas Sohajda
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