NovAliX

💡 Organic chemistry literature spotlight 💡 We highly recommend reading the recent article from Zhang and coworkers on 'Modular Access to Functionalized Oxetanes as Benzoyl Bioisosteres.' Very recently, oxetanyl trichloroacetamides appeared to be valuable intermediates for preparation of diverse functionalized 3-aryl oxetanes: ✅ Generation of a carbanion intermediate with unique stabilisation due to the oxygen presence ✅ Introduction of N or O nucleophiles (but not only) to form 3’-oxo- or 3’-amino-oxetanes (amide bioisosters)   👏 Congratulations to the authors for the development of this synthetic protocol accessing 3-aryl oxetanes compound: Dayu Tian, Guang Chen, Xiaocheng Wang, and @Hai-Jun Zhang. J. Am. Chem. Soc. 2024, 146, 26, 18011–18018 https://lnkd.in/e7tc_UaE University of Science and Technology of China 中国科学技术大学 #organicchemistry #chemistry #drugdiscovery #science

🌍 July 15: Happy World Youth Skills Day!  At NovAliX, we are proud to support the scientific careers of young students and we regularly welcome interns and apprentices throughout the year. 👩🔬👨🔬 On this special day, we want to highlight their skills and thank them for their dedication and hard work alongside us. To all the young talents who have joined us: Your enthusiasm, fresh perspectives, and commitment are invaluable to our teams. Discover some testimonials from our current trainees and apprentices who contribute to the future of science. Thank you for being part of the NovAliX journey! 🔬 👨🏼🎓 👩🏼🎓 Noélie Barrère, Bileile Boursas, Salma E., Nicolas Espanel, Thomas Gherardi, Axelle H., Charlotte Jadot, Valentin JUNKER, Emma L., Cheyenne L., Louis Leterme, Léo MEYER, Marie T., Lisa Tritsch, Capucine W., Robin W. #LifeAtNovAliX #WorldYouthSkillsDay #YouthEmpowerment #ScientificCareers #FutureScientists #Internship #Apprenticeship #SkillsRightNow **************************************************** 🌍 15 juillet : Journée mondiale des compétences des jeunes  Chez NovAliX, nous sommes fiers de soutenir les carrières scientifiques des jeunes étudiants et nous accueillons régulièrement des stagiaires et des apprentis tout au long de l'année. 👩🔬👨🔬 En cette journée spéciale, nous souhaitons mettre en avant leurs compétences et les remercier pour leur dévouement et leur travail acharné à nos côtés. À tous les jeunes talents qui nous ont rejoints : votre enthousiasme, votre regard neuf et votre engagement sont précieux pour nos équipes. Découvrez quelques témoignages de nos stagiaires et alternants actuels qui contribuent à l'avenir de la science.  Merci de faire partie de l'aventure NovAliX ! 🔬 #LaVieChezNovAliX #JourneeMondialeDesCompetencesDesJeunes #CarrieresScientifiques #FuturesScientifiques #Stages #Alternances #Apprentissages

🔜 Save the date! Join NovAliX at In-Cosmetics Korea 2024: 📆 from July 24 to 26 📌Seoul, South Korea Involved in cosmetics, flavors, fragrances and ingredients? Meet us at in-cosmetics Korea! As every project is different and every question requires specific approaches, we offer testing solutions tailored to your needs, from the most basic fraction of life to more complex tissues. Benefit from our suitable experimental models, from specific tests on standard or specific markers. 👩🏼🔬 Just set up a meeting with our team to discuss your scientific projects: Céline V., Associate Director Business Development, Cosmetics, flavors, fragrances & ingredients ▶ For more details: https://lnkd.in/dPJ7pTFN #inCosmetics #InCosmeticsKorea #BetterScience #CosmeticScience #cosmetics #PersonalCare #ingredients #NMR #invitroassays #Chemoinformatics

We’re exhibiting at RICT 2024 in Bordeaux (France) through July 5. 👀 Stop by to learn how Better Science is changing the future of drug discovery—and get a sneak peek of our fresh new look. 📌 Meet our dedicated team at booth 27: Anne de Villeroché, Anne P., Taouès Temal-Laib ▶ For more details: https://lnkd.in/ebHVJybW We're looking forward to seeing you there! #RICT2024 #BetterScience #DrugDiscovery #MedicinalChemistry #medchem #Biophysics #StructuralBiology #Pharmacology #ADME #DMPK #TranslationalScience

NovAliX is thrilled to be a Bronze Sponsor of the 18th edition of the Belgian Organic Synthesis Symposium held in Liège (Belgium) from June 30 to July 5, 2024. The BOSS-conference is a unique international symposium that brings together renowned organic chemists and rising stars in the field. This event features lectures on a broad range of cutting-edge topics in modern organic synthesis. Feel free to contact Erwin Coesemans, our Senior Project Manager in Chemistry, who also attends BOSS XVIII. He will be very happy to dive deep into the latest advancements in chemistry: https://lnkd.in/dpHNcesr We wish a successful symposium to the Symposium Chair Prof. Frank Glorius and to the Organizing Committee Chair Prof. Jean-Christophe Monbaliu. #BOSS_Symposium #BOSSXVIII #OrganicChemistry #Chemistry #ScientificExcellence #BronzeSponsor

💡 NovAliX publication hightlight 💡 Discover our latest scientific publication: "Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance", a co-authored work with Galecto, Inc. and Lund University. The group demonstrated that Surface Plasmon Resonance (SPR) is a robust alternative to Fluorescence Polarization (FP) for early drug discovery screening and determining affinity estimates. ✅ Kinetics data from SPR revealed differences in what drives affinity between species. In human galectin-1, slower dissociation increased affinity, while in mouse galectin-1, faster association was the key factor. ✅ Binding affinities for a selection of mono- and di-saccharides correlated well between FP and SPR assay formats for both human and mouse galectin-1. 🔬 This study underscores the potential of SPR in enhancing our understanding of galectin-1 interactions, paving the way for innovative therapeutic strategies. We are proud of the contributions from our dedicated team at NovAliX (Henry K., Louis Kretz, Céline RONIN, Christina S.) and are excited to share this advancement with the scientific community. 👏 Congratulations to the authors: Kim, H.; Kretz, L.; Ronin, C.; Starck, C.; Roper, J.A.; Kahl-Knutson, B.; Peterson, K.; Leffler, H.; Nilsson, U.J.; Pedersen, A.; et al. Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance.  Int. J. Mol. Sci. 2024, 25, 6704. https://lnkd.in/ePwxnSFq For more details: https://lnkd.in/eMqBYeH8 #DrugDiscovery #ScientificResearch #Galectin1 #SPR #MolecularScience #Innovation #Biophysics

🌟 Join us at FEBS 2024 in Milan (Italy) next week! The 48th pharmacology congress will focus on 'Mining biochemistry for human health and well-being'. Organized by the Federation of European Biochemical Societies, FEBS 2024 will cover a wide range of topics such as fundamental, emerging molecular and cellular life science. 👨🔬 Come and discuss your scientific projects with NovAliX! Meet Massimiliano Dal Rio, MSc, Business Development Manager for South Europe, on July 2 and 3. ▶ For more details and to contact us: https://lnkd.in/eDxcXNg4 #FEBS2024 #DrugDiscovery #Pharmacology #Chemistry #LifeScience #ScientificConference #Networking

📆 Save the date and meet us at RICT 2024 in Bordeaux! 🌟 Join us from July 3 to 5, 2024, at the 58th International Conference on Medicinal Chemistry organized by Société de Chimie Thérapeutique SCT. This year's theme 'Interfacing chemical biology and drug discovery' will feature 18 plenary lectures and 6 short lectures on cutting-edge scientific topics. 👩🔬 Visit us at booth no.27 and discuss your scientific projects with our dedicated NovAliX team: Anne de Villeroché, PhD, Associate Director Business Development Anne P., Director Business Development, Drug Discovery and Pharmacology Taouès Temal-Laib, PhD, Senior Research Fellow, Director Drug Discovery We look forward to connecting with you and exploring exciting new possibilities in medicinal chemistry! ▶ For more details and to contact us: https://lnkd.in/ebHVJybW #RICT2024 #MedicinalChemistry #medchem #DrugDiscovery #ScientificConference #Networking

💡 Organic chemistry literature spotlight 💡 Interested in a unified, practical and mild methodology for incorporation of sp3-fragments? We warmly recommend the new publication of Timothy Noel's Group. The photoinduced B-alkyl Suzuki-Miyaura cross coupling offers great advantages: ✅ Room temperature, thanks to Nickel catalysis & radical pathway ✅ B-alkyl partner readily available from telescoped Brown hydroboration (Alk-BH2 or Alk-B(BBN)2) ✅ Anhydrous or water-tolerant   A clear breakthrough in our arsenal of Csp²-Csp³ coupling methods. 👏 Congratulations to the authors: Wan, T., Capaldo, L., Djossou, J. et al. Rapid and scalable photocatalytic C(sp²)–C(sp³) Suzuki−Miyaura cross-coupling of aryl bromides with alkyl boranes. Nat Commun 15, 4028 (2024). https://lnkd.in/ehM3Uv6K #organicchemistry #flowchemistry #chemistry #drugdiscovery #science

🌟 NovAliX at the 5th Scientific Meeting GDR RNA We are thrilled to have participated in the GDR meeting dedicated to RNAs, held in the beautiful city of Strasbourg last June 10 to 11. This scientific event brought together multidisciplinary French teams focused on RNA research. 🔬 During the final session, our Biophysics team, represented by Scientist Eugenie L., showcased our expertise in studying interactions between small molecules and RNA using the cutting-edge SPR technique. 👏 A big thank you to all the organizers and participants for this enriching experience! #DrugDiscovery #Biophysics #RNAResearch #SPR #GDRMeeting #Teamwork