Inside Tx

After 2 years of dedicated development, we proudly unveil TAMARA - Our First microfluidic-based Nanoparticle Synthesis System! 🚀 Introducing TAMARA: Redefining Nanoparticle Synthesis for Drug Development 💡 Flexible Nanoparticle Types: Whether it's #LNP, #liposomes, or #PLGA nanoparticles to encapsulate and deliver RNA, Small drug, ASO... TAMARA empowers you with the flexibility to explore a broad range of nanoparticle with one single platform! 💊 ⏱️ User-Friendly & Quick: In less than 2 minutes, even for beginners, TAMARA completes a full synthesis and cleaning cycle! 🔬 Microfluidic Mastery: Leveraging the most advanced microfluidic technology, TAMARA ensures the utmost control over nanoparticle characteristics - size, PDI, EE% - to maximize your delivery efficiency. Precision at its finest! 📊🔍 🔄 Eco-Friendly & Reusable: Talking about cleaning, using TAMARA, you can reuse your microfluidic chips and reservoir effortlessly, allowing for multiple uses and reducing environmental impact. 🌱 🌐 Versatile Volumes: TAMARA covers the 0.2 to 10 mL range, making it your go-to for screening and preclinical development with one single platform 📈 #nanoparticles #TAMARA #RNA #Biotech

📢 Building on Our Recent LNP formulation Guide: How to further optimize your Lipid Nanoparticle Formulation Efficiency! 📢 Last week, we shared a helpful guide on getting started with Lipid Nanoparticle (LNP) formulation. Today, we're excited to take this discussion further by sharing this review titled "Rational Design of Lipid Nanoparticles: Overcoming Physiological Barriers for Selective Intracellular mRNA Delivery" by Yu Zhao & co. If you found our guide useful, this review is a great follow-up. It offers detailed insights into the process of mRNA delivery using LNPs. Here’s what you can expect: 🔬 Understanding the SCER Cascade: Learn about the four critical steps—Selective organ-targeting delivery, Cellular uptake, Endosomal escape, and Cytosolic mRNA Release—and why they are essential for effective mRNA therapies. 💡 Latest Innovations: Discover the newest advancements in LNP-based mRNA delivery, focusing on overcoming technical and clinical challenges and exploring future developments. Whether you're new to LNP formulation or seeking to expand your knowledge, this article is an excellent resource: Read the full article here to stay ahead in the fast-changing field of mRNA therapeutics: https://lnkd.in/gtEk_Fj3

🔬 Revolutionizing Drug Delivery: The Manufacturing of PLGA Nanoparticles! 🚀 Dive into the world of advanced drug delivery systems with our latest review on the formulation process of PLGA nanoparticles. Discover the innovative techniques that make the effective production of these nanoparticles possible. Explore the key aspects of PLGA particles and their production: 📚 Introduction to PLGA: Understand the composition and unique properties that make PLGA particles ideal for drug delivery. 🏭 Manufacturing Methods: Delve into the various techniques used to produce PLGA nanoparticles, including emulsion, spray drying, and microfluidics. Learn how these methods ensure precision and efficacy in drug delivery applications. ❓ Microfluidics Mastery: Gain insights on choosing the right microfluidic approach based on the specific characteristics of the PLGA particles you need. Join the conversation on how these cutting-edge manufacturing techniques are transforming the landscape of drug delivery systems. 👉 Read more: https://lnkd.in/eFpzY_wX

🚀 Exciting News for our US partners! 🚀 Following our insightful participation at CRS last week, we're thrilled to announce our upcoming involvement in the 2024 Nanotechnology Delivery Systems (NanoDDS) Symposium at the University of Florida from September 13-15! This prestigious event is a fantastic platform to explore next-generation delivery vehicles. From targeted and responsive to biodegradable nanomaterials, this symposium leads the way in making diagnostics more sensitive and drugs more effective. 🌟 Join us in Orlando, FL, as we dive into engaging discussions and witness innovative research presentations, including the latest advancements in our NanoPulse technology. For the first time, we'll also be showcasing our TAMARA nanoparticle formulation system in the US! But that's not all! We'll be traveling across the US prior to the symposium, making it a perfect opportunity to connect. If you're interested in discovering our nanoparticle formulation systems, discussing potential collaborations, or simply catching up, let's arrange a meeting! 📅 Save the date and let's make the most of this exciting journey together. Looking forward to seeing you there! #NanoDDS2024 #Nanotechnology #DrugDelivery #Innovation #Networking #UF #Research #Collaboration #MeetUsInTheUS

Embarking on the journey of Lipid Nanoparticle (#LNP) formulation for oligonucleotide/RNA delivery might initially appear complex and intimidating. However, rest assured, the process is more straightforward than it looks! Here's a straightforward guide to get you started:   1/ Identify Your Oligonucleotide/RNA 🧬: Whether it's #mRNA, #siRNA, sgRNA, or #ASO, the choice of nucleic acid hinges on your therapeutic goal.   2/ Lipid Selection 🔬: Numerous lipid combinations exist, each suited to different cargoes and cell/organ targets. We suggest starting with proven LNP compositions to ease the development process, before exploring more complex solutions. Find out more about those here: https://lnkd.in/eE7vA6UB   3/ Formulation Design 🧪: Picking the right buffers, pH, N:P ratio... is key. For example, lipids are dissolved in an organic solvent, typically ethanol. An acidic buffer is needed in the aqueous phase to ionize the lipids during complexation with RNA.    4/ Efficient Mixing Process 🌀: Employ a microfluidics-based system to mix aqueous and organic phases effectively and homogeneously, ensuring seamless RNA-LNP complex formation for optimal physicochemical parameters control.   5/ Parameter Optimization 🛠️: Fine-tune the synthesis conditions (flow rates and concentrations) to nail the perfect particle size, PDI, and encapsulation efficiency. Remember, these factors are key to efficient RNA-LNP intracellular delivery.   6/ Improve Selectivity (Optional) ➕ : Consider decorating LNPs with ligands or peptides for targeted delivery to specific cell types (also known as active targeting.)   7/ Test, Refine, Repeat 😎: Physicochemical characterization and, in vivo and in vitro testing are key. While general guidelines can be drawn, LNP formulation should be optimized for each payload and target. This iterative process refines the LNP composition and manufacturing for optimal performance.   Interested in diving deeper or need assistance? Our application specialists are here to introduce you to our latest LNP development services.   Looking to formulate nanoparticles independently? Explore our Tamara LNP formulation platform, which seamlessly combines cutting-edge microfluidics technology with user-friendly design: https://lnkd.in/epmSVc4P.

Nous #recrutons (#hiring) toujours, non pas un poste mais 2 Ingénieurs R&D généralistes pour développer notre technologie💪 Pourquoi nous rejoindre ? 😎 100% de nos collaborateurs embauchés travaillent 😍 100% des collaborateurs que nous n'avons pas licenciés sont heureux de travailler chez nous -- et la complémentaire: 😆 0% ont été licenciés. Vous l'aurez compris, nous ne sommes pas friands de statistiques sur les personnes. Mais nous prenons grand soin à ce que notre équipe conserve son énergie et si vous souhaitez savoir s'il fait bon travailler chez nous, demandez simplement à ceux qui y sont: Robin, Audrey, Yannick, Julien, Elio, Matthieu, Hélène, Rebecca, Thania, Kevin, Céline, Thibault.

4th and last day at #CRS2024 for our InsideTx team ! If we have not had the chance to meet, please drop by our booth so we can introduce you to our TAMARA platform!🚀 Ci vediamo presto 😊

Day #3 at #CRS2024: Elio GEREIGE is presenting his poster on our groundbreaking NanoP technology! Quick reminder: NanoP aims to be the first nanoparticle/RNA-LNP formulation system capable of covering every scale—from µL to L—while maintaining consistent nanoparticle characteristics. This revolutionary technology addresses a significant limitation in nanomedicine development by streamlining the scale-up process. Interested in learning more? Visit poster #1195 to speak with Elio!

Inside Therapeutics at #CRS2024 ! After a longer-than-expected journey, we’ve finally arrived at the annual Controlled Release Society event in Bologna! Come visit us at Booth #31 or check out our poster #1248 to chat about our TAMARA nanoparticle formulation system! If you're interested in learning more about our groundbreaking NanoP technology for scaling up nanoparticle formulation, don't miss Poster #1196! See you there!!

Quelle quinzaine dense pour l'écosystème santé en Nouvelle Aquitaine ! La semaine passée se réunissait les membres du cluster santé ALLIS-NA | Alliance Innovation Santé Nouvelle-Aquitaine afin de renouveler son Conseil d'Administration auquel j'ai eu le privilège d'être élu. Sous la Présidence de Philippe Lamoureux, cette belle équipe, va œuvrer pour faire rayonner l'écosystème santé dans la Région Nouvelle-Aquitaine et au-delà. Ce vendredi dernier, nous participions à la Journée Nationale de la Bioproduction de Biothérapies, organisée par France BioLead (bravo Caroline Bernard !) et ALLIS NA (bravo Alice Leroux, PhD !). Je n'ose imaginer le travail de préparation derrière cette journée où une trentaine de sites de bioproduction ont ouvert leurs portes. Un immense merci de faire vivre notre filière et de nous permettre de nous rencontrer, de tisser des liens, de mailler le territoire, de pouvoir tout simplement échanger en passionnés sur les sujets santé ! L'occasion aussi de présenter notre projet Inside Tx de bioproduction de nano médicaments avec Thania. Merci à Michael et Frédéric pour leur accueil chaleureux et le récit de cette aventure extraordinaire qu'est TreeFrog Therapeutics : bravo et merci pour ce que vous faites. Merci à Laure VALOGNES d'avoir accueilli tout le réseau sur leur somptueux site de Merck Martillac, c'est impressionnant (je suis redevenu étudiant le temps de la visite !!) Que du bonheur !