Written by Jessica Thomas, Fortune Recommends Writer
Research on probiotics and their potential health benefits has increased in the last decade. Today, many people view probiotics as a staple in their medicine cabinets, along with a high-quality multivitamin. However, not all probiotics are created equally.
Our team of registered dietitians, certified personal trainers, and health coaches has tried 20 probiotic supplements and researched dozens of others. After assessing their efficacy, safety, value, and more, we’ve named the 12 best probiotics available today. We’re here to share our professional reviews and insights and help you select a daily probiotic supplement that aligns with your lifestyle and health goals.
Best probiotic overall
Ritual Synbiotic+ is our best probiotic overall. This vegan-friendly supplement offers a trifecta of prebiotics, probiotics, and postbiotics while remaining free of major allergens and banned substances.
Medical disclaimer: This article is intended for educational and informational purposes only. It is not intended as a substitute for medical advice. For health advice, contact a licensed healthcare provider.
Our picks for the best probiotic
- Best overall: Ritual Synbiotic+
- Best for athletes: Onnit Total Gut Health
- Best affordable: Nutricost Lactobacillus Acidophilus
- Best vegan: Sports Research Daily Probiotic
- Best for weight loss: ColonBroom
- Best for gut health: Transparent Labs Gut Health
- Best for men: Biotics 8 Men’s High Performance Probiotic Formula
- Best for skin: YourBiology Gut+
- Best for bloating: Seed DS-01 Daily Synbiotic
- Best for constipation: Physician’s Choice 60 Billion Probiotic
- Best for IBS: Nature Made Digestive Probiotics Advanced Dual Action Capsules
- Best for women: Hum Nutrition Private Party
- Best for inflammation: Bioma Probiotics
Compare probiotics
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| Ritual Synbiotic+ | Onnit Total Gut Health | Nutricost Lactobacillus Acidophilus | Sports Research Daily Probiotic | ColonBroom | Transparent Labs Gut Health | Biotics 8 Men’s High Performance Probiotic Formula | YourBiology Gut+ | Seed DS-01 Daily Synbiotic | Physician’s Choice 60 Billion Probiotic | Nature Made Digestive Probiotics Advanced Dual Action Capsules | Hum Nutrition Private Party | Bioma Probiotics | |
| Rating | |||||||||||||
| Price | $54 | $75.90 | $19.95 | $24.95 | $70 | $45.99 | $80 | $80 | $50 | $25.95 | $28.69 | $26 | $56 |
| Daily dose | 1 capsule | 7 capsules | 1 capsule | 1 capsule | 1 scoop | 2 capsules | 3 capsules | 3 capsules | 2 capsules | 1 capsule | 1 capsule | 1 capsule | 2 capsules |
| Key ingredients | Probiotic Blend, PreforPro®, and Tributyrin | 5 probiotic strains, HCl, prebiotics, digestive enzymes | Lactobacillus Acidophilus | 12 probiotic strains, fiber inulin blend | Psyllium Husk Powder | 10 probiotic strains, FOS | Vitamin D3, 10 probiotic strains | Vitamin D3 Proprietary blend of 10 strains of bacteria | 4 probiotic blends | 10 probiotic strains | Lactobacillus rhamnosus GG, Bifidobacterium lactis HN019™ | 3 probiotic strains, cranberry extract | Bifidobacteria, Tributiryn, Xylooligosaccharides |
Medical disclaimer: This article is intended for educational and informational purposes only. It is not intended as a substitute for medical advice. For health advice, contact a licensed healthcare provider.
Best probiotic overall: Ritual Synbiotic+
Key product features
What you should know
Ritual Synbiotic+ is a vegan-friendly probiotic supplement with traceable, evidence-backed ingredients in a mint-flavored, delayed-release capsule.
- Our product tester, who struggles with symptoms associated with IBS, said he experienced better digestive health after trying Ritual Synbiotic+.
- At $1.80 per serving, this probiotic supplement is priced slightly above average.
- Ritual Synbiotic+ is designed for consumers who want a combination of researched prebiotics, probiotics, and postbiotics that may help balance the gut microbiome.
- Individuals may experience some flatulence and other G.I. symptoms when they first start taking it.
Why we like Ritual Synbiotic+ as best overall
Ritual Synbiotic+ isn’t just a probiotic—it’s a prebiotic and postbiotic , too. Probiotics are health-benefiting body bacteria found mostly in the lower digestive tract. They are also in some foods, like yogurt, and dietary supplements. Prebiotics feed that good bacteria. Postbiotics are the materials left behind after your body digests the probiotics and prebiotics that include certain vitamins and beneficial nutrients. Together, all three can boost gut health and may even aid the management of metabolic diseases. ( 1 )
Ritual Synbiotic+ is a vegan-friendly supplement with clinically studied ingredients you can trace back to their source. One serving includes 11 billion colony-forming units (CFUs, or the number of live microorganisms that can settle in your gut after consumption) of two of the most researched probiotic strains: Lactobacillus rhamnosus (LGG®) and Bifidobacterium animalis ssp. lactis (BB-12®).
Studies show that LGG® may help with ulcerative colitis and lactose intolerance. ( 2 ) ( 3 ) ( 4 ) Research also suggests that BB-12® may improve diarrhea and bowel function and alleviate side effects associated with antibiotics. ( 5 )
In addition, there are 15 milligrams of PreforPro®, a trademarked non-fiber-based prebiotic. A 2020 study found that using PreforPro® with the Bifidobacterium animalis probiotic may boost the probiotic’s effects. ( 6 )
Synbiotic+ also contains 300 milligrams of the butyric acid-releasing postbiotic agent, Tributyrin. Butyric acid may prevent and treat intestinal inflammation and diarrhea. ( 7 )
One of our product testers, who has irritable bowel syndrome, said he noticed less bloating after taking Synbiotic+. He also felt like his digestive health had improved, and his gut felt more normal.
Another product tester said the mint-flavored, delayed-release capsule was smaller than other supplement pills he’s tried. He also remarked that it went down seamlessly and was glad he only had to take one daily.
At $1.80 per serving, Ritual Synbiotic+ is on the expensive side. However, these probiotics are third-party tested, and Ritual tests each batch for strength, purity, and more.
You must sign up for a monthly subscription when you purchase Ritual Synbiotic+, but you can cancel at any time. Ritual also offers a 30-day money-back guarantee if you don’t like the supplement.
What customers are saying
On Amazon, customers have mainly positive reviews about Ritual Synbiotic+, but many commented on its higher price and minty taste.
For example, verified Amazon buyer Dovelette remarked, “It makes taking all necessary ‘biotics’ a breeze instead of buying individual options that often come in ugly containers or require space in the fridge. I do wish that the price was lower because it’s too pricey to justify.”
Another Amazon reviewer, Jay, mentioned, “These have made me feel so much better. They can be a bit pricey, and you get the occasional fishy burp, but I wouldn’t trade them for the world.”
Specs
| Dosage instructions | 1 capsule per day |
| Strains | Two |
| CFUs | 11 billion |
| Servings per container | 30 |
| Cost per serving | $1.80 |
Best probiotic for athletes: Onnit Total Gut Health
Key product features
What you should know
With Onnit Total Gut Health, you’re getting five supplements in one. Each packet contains seven capsules of nutrients that help promote a healthy gut microbiome and digestive system.
- Onnit is crafted with five of the most beneficial probiotic strains for supporting digestive health and function.
- At $2.53 per serving, Onnit is more expensive than the average probiotic. But, when you consider the other supplements in the formula, it may be worth it.
- With probiotics, prebiotics, digestive enzymes, saccharomyces boulardii, and HCl, Onnit is an excellent option for consumers looking for a complete solution for optimal digestion and a healthy gut microbiome.
Why we like Onnit Total Gut Health as best for athletes
Onnit Total Gut Health isn’t your typical probiotic–it’s a 5-in-1 formula that contains probiotics, betaine hydrochloride (HCl), saccharomyces boulardii , prebiotics, and digestive enzymes spread out over seven capsules. Each serving comes in an individual packet, so you won’t have to worry about keeping track of capsules—you can just take a packet a day.
Onnit’s probiotic blend contains 10 billion CFUs from five well-studied probiotic strains . Lactobacillus acidophilus DDS-1 is known for supporting digestive and immune system health. ( 14) L. plantarum helps enhance overall digestive wellness. ( 41 ) L. rhamnosus and Bifidobacterium infantis may aid in reducing diarrhea and symptoms of IBS. ( 2 ) B. lactis supports digestion and may help ease symptoms of lactose intolerance. ( 6 ) HCl helps your body create more stomach acid, which also helps break down food. ( 11 )
Onnit’s prebiotic capsule contains Jerusalem artichoke and dandelion, both of which can support the growth of beneficial gut bacteria and promote a healthy microbiome. ( 30 ) The HCl capsule works to help your body create more stomach acid, which also helps break down food. ( 11 ) The DigesTech blend is designed to further support digestion. And the saccharomyces boulardii capsule adds another 5 billion CFU to your serving size, bringing you to 15 CFU total.
A 30-day supply of Onnit costs $75.90, putting each serving at $2.53. While this is one of the more expensive options on the market, it may be worth it when you consider how many supplements it can replace.
At this price point, we’d prefer to see third-party testing and more label transparency. For example, the CFU of each probiotic strain is not provided, nor is the amount of each ingredient in the DigesTech blend®. This makes it difficult to determine the efficacy and safety of these ingredients.
What customers are saying
On Amazon, Onnit Total Gut Health has received 325 global ratings, most of which are positive. Customers regularly comment on the quality and performance of this supplement. Some of the less positive reviews are due to the price.
For example, verified Amazon buyer Maha Sayad wrote, “Love these pills. They’ve helped my stomach so much with bloating. I wish they were cheaper though.”
Another Amazon reviewer, CJ, remarked, “[This] product works great. I could not be happier.”
Specs
| Dosage instructions | 7 capsules (1 packet) per day |
| Strains | Five |
| CFUs | 15 billion |
| Servings per container | 15-30 |
| Cost per serving | $2.53 |
Best affordable probiotic: Nutricost Lactobacillus Acidophilus
Key product features
What you should know
Nutricost Lactobacillus Acidophilus Capsules provide 10 billion CFU of a single strain of friendly gut bacteria.
- Lactobacillus acidophilus is one of the most well-researched probiotic strains and has been extensively studied in humans for the last two decades.
- At just under $0.17 per serving, Nutricost Lactobacillus Acidophilus Capsules are one of the most affordable probiotics on the market.
- This simple formula offers a targeted approach for those looking to address specific digestive issues or maintain overall gut health.
Why we like Nutricost Lactobacillus Acidophilus as best affordable
Nutricost Lactobacillus Acidophilus Capsules, with 10 billion CFU, offers a simple yet effective way to support digestive health. The supplement is an excellent way to introduce more L. acidophilus into your digestive system. This is simply a friendly bacteria that lives in your gut and helps keep things running smoothly. Proper amounts of L. acidophilus can help improve digestion and prevent problems like bloating and gas. ( 14)
Using a probiotic with just one strain, like Nutricost’s Lactobacillus Acidophilus Capsules, is a more targeted approach that can be beneficial for individuals looking to address specific digestive issues or simply maintain overall gut health.
L. acidophilus has been widely studied for decades, and its role in many diseases and other aspects of human health is constantly being explored. This strain may enhance immunity, help reduce cholesterol, and even have anti-cancer properties. ( 14)
At just under $0.17 per serving, Nutricost Lactobacillus Acidophilus Capsules are cost-effective and accessible. Plus, you can enroll in a subscription and save an additional 20%. On top of its great value, our team appreciates that Nutricost is made in a GMP-compliant facility, is non-GMO, and even comes with a 60-day money-back guarantee.
What customers are saying
Nutricost Lactobacillus Acidophilus Capsules has garnered over 1,400 reviews on Amazon, most of which are positive. Buyers regularly comment on the value, quality, and performance.
“I have only been taking it for a week, and it seems to be working well.”
Deborah A., Amazon
Another Amazon buyer named Sydney H. wrote, “I was hesitant to buy these because of the price, but they work well! I’m impressed!”
However, some Amazon customers weren’t as impressed with the results, or lack thereof.
For example, Denise S. mentioned, “I wanted to give this a try, but there was no improvement. I found drinking Kefir worked better than popping a pill.”
Specs
| Dosage instructions | 1 capsule daily |
| Strains | One |
| CFUs | 10 billion |
| Servings per container | 120 |
| Cost per serving | $0.17 |
Best probiotic for vegans: Sports Research Daily Probiotic
Key product features
What you should know
Sports Research Daily Probiotics emerge as our top choice for vegan-friendly probiotics, thanks to a diverse mix of probiotic strains and a dedication to efficacy and high-quality ingredients.
- This formula delivers optimal gut support, featuring 12 lactobacilli and bifidobacteria probiotic strains and a potent dose of 60 billion CFUs per serving.
- Priced at $0.83 per serving, Sports Research Daily Probiotics provide exceptional value, making it an affordable option for those prioritizing gut health.
- Sports Research products are third-party tested and manufactured in a cGMP-compliant facility.
Why we like Sports Research Daily Probiotic as best for vegans
Sports Research Daily Probiotics is packed with 12 research-backed strains of probiotics, carefully chosen to maximize digestive and immune system health. The formula is vegan-certified and non-GMO verified.
The supplement contains probiotic strains, like Lactobacilli and Bifidobacteria , to target symptoms associated with IBS, such as bloating and abdominal discomfort, while also potentially supporting immune, gastrointestinal, and reproductive health in healthy adults. ( 20 , 62 )
Additionally, a fiber inulin blend acts as a prebiotic, promoting optimal gut health, enhancing nutrient absorption, and strengthening the immune system. Research indicates that inulin could aid in fat metabolism, weight loss, and blood sugar regulation. Moreover, it may lower the risk of colon cancer and alleviate symptoms of depression. ( 9 )
These probiotics don’t require refrigeration, making them perfect for busy lifestyles. The delayed-release veggie capsules ensure the probiotics reach your colon intact. Plus, the 60 billion CFU potency is guaranteed until the product’s expiration date.
Priced at $0.83 per serving, Sports Research Daily Probiotics provides exceptional value compared to similar quality supplements. Sports Research products are third-party tested and manufactured in a cGMP-compliant facility with stringent quality control standards.
What customers are saying
On Amazon, there are over 5,000 ratings for Sports Research Daily Probiotics. Most of the reviews are positive.
A verified customer named Amanda wrote, “Honestly, I’ve only taken it for maybe four days now, and I’ve already seen improvements in my gut health and digestive system.”
“These daily probiotics have been a true lifesaver for my easily irritable gut!”
AnalogCyan, Amazon
The few negative reviews are over two years old. Some customers experienced gas, bloating, or an upset stomach, while others didn’t notice improvements in their digestive function.
“There has been no improvement to my overall gut health since starting to take this product,” wrote verified Amazon customer Ryan Rhoades. It was well worth a try, but I will not buy this again.”
Specs
| Dosage instructions | 1 capsule daily |
| Strains | One |
| CFUs | 10 billion |
| Servings per container | 120 |
| Cost per serving | $0.17 |
Best probiotic for weight loss: ColonBroom
Key product features
What you should know
This vegan and keto-friendly supplement includes psyllium husk powder, a high-fiber substance that may reduce appetite and decrease waist circumference.
- ColonBroom may help with weight loss when paired with physical activity and positive dietary changes.
- At $1.17 per serving, this formula is priced well above average compared to other products with psyllium husk powder.
- It may be best for those making dietary changes and increasing physical activity who want more support for their weight-loss goals.
Why we like ColonBroom as best for weight loss
ColonBroom is a high-fiber dietary supplement that may improve digestive health and weight loss. It claims to strengthen gut health, diminish bloating, and make people feel lighter.
The primary ingredient in the ColonBroom formula is psyllium husk powder, a soluble fiber with prebiotic effects that is occasionally used to remedy constipation. ( 42 ) However, one study found that it could help individuals feel less hungry, which may reduce weight. ( 43 )
Psyllium husk helps support the growth and reproduction of probiotics. ( 44 ) Our gut microbiome already has these live microorganisms, but psyllium husk may improve the overall intestinal environment.
ColonBroom is strawberry-flavored and available in powder form. One scoop equals one serving, which you add to an 8-ounce glass of water. The company recommends starting with one serving daily, taking it an hour before your meal, and then working up to two servings.
If you opt for the one-time purchase of ColonBroom, you’re looking at about $1.17 per serving, which is slightly above average but still reasonable. This vegan and keto-friendly product excludes gluten, sugar, or GMOs. However, it may initially cause undesirable G.I. symptoms, and we don’t like the $15 return shipping fee. We also couldn’t confirm if it was third-party tested.
What customers are saying
Verified Amazon purchaser Shelley M. said ColonBroom tasted good and was easy to drink. She also stated that it “worked within a couple of days.”
“When I say this works, please stay near a bathroom. I have a digestive condition, so I started doing this once a day after dinner, followed by a bottle of water. The flavor is amazing—it tastes like strawberry Kool-Aid.”
Ms. Ragland, Amazon
Verified Amazon buyer Amanda L. loved the flavor but didn’t like the price. She said, “Mixes easily with cold water, no clumps! It doesn’t hurt my stomach and seems to work ok. It’s just the price I can’t get over. I expected a bigger container than what I got.”
Specs
| Dosage instructions | One scoop of powder with 8oz -14oz water |
| Strains | Undisclosed |
| CFUs | Undisclosed |
| Servings per container | 60 |
| Cost per serving | $1.17 |
Best probiotic for gut health: Transparent Labs Gut Health
Key product features
What you should know
Transparent Labs Probiotic is packed with potent probiotic strains designed to bolster overall digestive health and address factors linked to constipation.
- Transparent Labs Probiotic contains 100 billion CFUs. The 10 strains in its formula are clinically studied and dosed effectively.
- At $1.53 per serving, this probiotic is priced slightly above average. However, we think it’s worth it for the third-party testing and potency of the ingredients.
- The strains found in Transparent Labs Probiotic aid in regulating bowel movements and enhancing gut transit time, promoting overall gut health and functionality.
Why we like Transparent Labs as best for gut health
Transparent Labs Probiotic is our top choice for gut health because it boasts a blend of 10 probiotic strains designed to support overall gastrointestinal function. The combination of Lactobacilli and Bifidobacteria strains may promote a healthy gut environment, potentially aiding in digestion and nutrient absorption. ( 59 )
Specific strains like Lactobacillus casei, Bifidobacterium lactis, Bifidobacterium bifidum , and Bifidobacterium breve have demonstrated benefits in supporting digestive health by promoting regular bowel movements and enhancing stool consistency. ( 60 )
Additionally, the inclusion of 100 milligrams of inulin fructooligosaccharide (FOS) powder provides nourishment for the beneficial bacteria in your gut, potentially contributing to a balanced microbiota and supporting overall gut function. ( 61 )
The formula contains 100 billion CFU that are guaranteed to be potent until the expiration date. This is important because probiotics need to be alive to be beneficial.
With its emphasis on potency, transparency, and quality ingredients, Transparent Labs Gut Health Series Probiotic offers value beyond its $1.53 cost per serving. Moreover, it caters to various dietary preferences, being non-GMO, gluten-free, and suitable for vegans.
Specs
| Dosage instructions | 2 capsules per day |
| Strains | 10 |
| CFUs | 100 billion |
| Servings per container | 30 |
| Cost per serving | $1.53 |
Best probiotic for men: Biotics 8 Men’s High Performance Probiotic Formula
Key product details
What you should know
Biotics 8 includes 10 probiotic strains and other ingredients that may help improve men’s overall health.
- A serving size is three capsules, but you should start with one capsule daily to see how your body tolerates it.
- At $2.67 per serving, Biotics 8 is priced well above average when compared to other probiotic supplements.
- Biotics 8 may be a good choice for men who want to optimize their testosterone levels, improve digestion, and increase their energy.
- These are not suitable for vegan diets.
- Customers can save money by ordering a two- or three-month supply.
Why we like Biotics 8 Men’s High Performance Probiotic Formula as best for men
Biotics 8 Men’s High Performance Probiotic Formula is specifically crafted to support men’s gut and immune health. With 10 strains of probiotics in just one product, it may improve mood, gut health, energy, and more.
In addition to 10 probiotic strains, Biotics 8 contains vitamin D3, prebiotics, and three digestive enzymes. The body needs vitamin D3 to help build and maintain bones, and lacking it may increase one’s risk of immune-related diseases and disorders. ( 8 )
The prebiotic inulin stimulates the growth of good bacteria and may alleviate colon cancer risk, reduce blood sugar, promote weight loss, and aid digestive issues like constipation. ( 9 ) Another prebiotic, fructooligosaccharide, could boost levels of good gut bacteria, though it may cause bloating and gas in some people. ( 10 ) The digestive enzymes lipase, protease, and amylase help the body break down food and absorb nutrients. ( 11 )
Biotics 8 provides 20 billion CFUs of probiotics, including strains like Lactobacillus casei and Bifidobacterium longum . These strains may help with the severity of conditions like irritable bowel syndrome and inflammatory bowel disease. ( 12 ) ( 13 )
A bottle of Biotics 8 provides 30 servings and costs $80, about $2.67 per serving. Compared to other probiotics, these are a lot more expensive than average. Plus, three capsules equals one serving, making it a deal-breaker for those with pill aversion. We also couldn’t find any information about third-party testing.
What customers are saying
There are only two English reviews on Trustpilot, and they’re both negative. Customers were disappointed by the customer service they received.
Ian Wilson stated that he never received his order. He mentioned that when he contacted Biotics 8, they just “Repeated ‘off the shelf’ replies to my emails, which took two days to reply.”
Another reviewer, David Commeau DJ, remarked that it took 10 days for his order to arrive. He didn’t notice any changes after taking them. He said, “Still debating on whether or not it would be worth my time and money to return them, considering I may never see a refund.”
Specs
| Dosage instructions | 3 capsules per day |
| Strains | 10 |
| CFUs | 20 billion |
| Servings per container | 30 |
| Cost per serving | $2.67 |
Best probiotic for skin: YourBiology Gut+
Key product features
What you should know
YourBiology Gut+ includes probiotics and vitamin D, as well as digestive enzymes that may enhance the body’s ability to break down and absorb nutrients.
- According to our product tester, the instructions differ from those for other probiotics. You have to gradually work up to three capsules.
- It costs $2.67 per serving, above the market average for probiotic supplements.
- YourBiology Gut+ is best for individuals who prefer holistic approaches to improving their skin health.
- Purchasing in bulk can offer significant cost savings. For instance, if you buy a two-month supply, you’ll get one container for free.
Why we like YourBiology Gut+ as best for skin
YourBiology Gut+ is a probiotic supplement with ingredients that may support the largest organ in the body: the skin. This dairy- and soy-free formula is prepared in a US-based, GMP-certified facility and comes with a 60-day money-back guarantee.
YourBiology Gut+ includes three digestive enzymes, a proprietary blend of 10 probiotic strains, two prebiotics, and vitamin D3. The digestive enzymes support the breakdown of food and absorption of nutrients, which may help the body adequately receive the other ingredients in this supplement.
Vitamin D3 has protective and anti-aging effects on the skin due to its antioxidant- and anti-inflammatory-supporting properties. ( 17 ) The prebiotics could promote the growth of good bacteria not only in the gut but also in the skin microbiome. ( 18 )
Each serving of YourBiology Gut+ has 20 billion CFUs. One of its 10 probiotics is L. paracassei , a species claimed to help with skin recovery and alleviate local skin inflammation. ( 19 )
YourBiology Gut+ comes in vegetarian capsules that may move through the digestive tract more easily than gelatin capsules. The instructions state you should take one capsule daily for the first four days, two capsules until day nine, and three capsules daily after that. Our product tester said this process was different from other probiotic supplements she’s tried, but besides that, she had no complaints.
At $2.67 per serving, this is a pricier probiotic supplement. It includes evidence-supported ingredients and is suitable for most diets, but it lacks proof of third-party testing and has zero verified reviews.
Specs
| Dosage instructions | 3 capsules per day |
| Strains | 10 |
| CFUs | 20 billion |
| Servings per container | 30 |
| Cost per serving | $2.67 |
Best probiotic for bloating: Seed DS-01 Daily Synbiotic
Key product features
What you should know
Seed DS-01 Daily Synbiotic offers a prebiotic and probiotic blend to support a healthy gut microbiome.
- The two-in-one ViaCap capsule may help safeguard the ingredients as it travels to the intestines.
- At $1.66 per serving, Seed DS-01 Synbiotic is mid-tier for probiotics, but the company offers a discount to military personnel, first responders, teachers, and students.
- This probiotic may be best for those who prefer scientifically validated probiotic formulas that receive extensive quality checks.
- You can save by ordering a three- or six-month supply.
Why we like Seed DS-01 Daily Synbiotic as best for bloating
Sixteen of the 24 probiotic strains in Seeds DS-01 Daily Synbiotic are dedicated to gut health. A single serving of DS-01 Daily Synbiotic contains 53.6 billion active fluorescent units (AFU), and 37 billion AFU come from the digestive health probiotic blend alone. AFU is another method of measuring the number of active probiotic cells that may be more accurate than measuring CFUs.
Some of the probiotic strains include Bifidobacterium longum , Lacticaseibacillus rhamnosus , and Bifidobacterium lactis . Research suggests these strains may improve bowel dysfunction in gastrointestinal motility disorders and G.I. symptoms caused by antibiotics. ( 20 ) ( 21 ) ( 22 ) Furthermore, Limosilactobacillus fermentum may help with inflammatory diseases like intestinal inflammation. ( 23 )
Seed DS-01 Daily Synbiotic is essentially a capsule within a capsule. The outer capsule contains a solubilized prebiotic blend, and the inner capsule includes the probiotic strains. This helps prevent the ingredients from getting burned by stomach acid so they can successfully reach the small intestine.
According to Seed, this 2-in-1 pre- and probiotic also undergoes over 50 quality control checkpoints. It’s third-party tested for 500+ pesticide residues and heavy metals.
Purchasing this probiotic supplement requires signing up for a monthly subscription. The first order comes with a refillable glass jar, a glass travel vial, and a 30-day supply of capsules. Subsequent orders contain a one-month refill until you reschedule or cancel. Seed offers a 30-day money-back guarantee, which might be attractive to those on the fence.
At just $1.66 per serving, this synbiotic comes at a reasonable price and potentially offers a lot of value to those wanting to improve their gut microbiome. It’s vegan-friendly and free of soy, gluten, and various allergens, making it a solid choice for most.
What customers are saying
On Amazon, verified purchaser Natalie remarked that she loved the product for herself and her daughter. She proclaimed, “I really like that I don’t have to refrigerate them, and both the capsules and the powder packets travel very well. Our family is going to keep taking these, and I’m hopeful our immunity will improve!”
Another Amazon buyer, Cathy, experienced a few side effects after trying the product for three days. She stated, “Suffered cramping, bloating, nausea. The worst side effect was severe flatulence. Stopped for a couple of days, and symptoms stopped.”
Specs
| Dosage instructions | Shelf-stable |
| Strains | 24 |
| CFUs | N/A; 53.6 billion AFU |
| Servings per container | 30 |
| Cost per serving | $1.66 |
Best probiotic for constipation: Physician’s Choice 60 Billon Probiotic
Key product features
What you should know
Created in a Certified GMP facility and non-GMO verified, Physician’s Choice 60 Billion Probiotic also includes prebiotics to help relieve constipation.
- Their evidence-backed ingredients can relieve constipation and promote more regular bowel movements.
- At $0.87 per serving, this is one of the more budget-friendly probiotics.
- Physician’s Choice 60 Billion Probiotic is ideal for those looking for a cost-effective, holistic approach to improving the frequency of their bowel movements.
- You can save by ordering a two-month supply or signing up for a one-, two-, or three-month subscription.
Why we like Physician’s Choice 60 Billion Probiotic as best for constipation
Constipation is a common G.I. problem associated with worse health-related quality of life ( 26 ). Physician’s Choice 60 Billion Probiotic is a potential solution for those struggling with constipation or other digestive issues.
One serving of the 60 Billion Probiotic contains 10 probiotic strains and 150 milligrams of a prebiotic blend. One of its probiotic strains, Bifidobacterium lactis , may positively affect bowel movement frequency, and Lactobacillus casei enhances stool consistency and constipation symptoms. ( 27 ) Further, prebiotics, specifically inulin, may also help with stool frequency. ( 27 ) Chicory root is a source of inulin found in this formula.
Prebiotics and probiotics have a synergistic effect when used together. They may elevate short-chain fatty acids (SCFAs), which support smooth muscle contractions in the colon, thus helping with constipation symptoms. ( 28 ) In addition, they could boost the production of mucin (which acts as a lubricant) and lower intestinal pH, which may balance the gut microbiota. ( 29 )
The other prebiotics in this formula, Jerusalem Artichoke Root and Acacia Senegal, may also improve the quality of bowel movements and prevent constipation altogether. ( 30 , 31 )
Physician’s Choice 60 Billion Probiotic is gluten-free, non-GMO certified, and compliant with Current Good Manufacturing regulations. It’s also third-party tested for purity and potency.
Physician’s Choice recommends taking one veggie capsule daily, and one container includes 30 servings. It’s also a very affordable probiotic supplement, costing only $0.87 per serving.
What customers are saying
On Amazon, there are over 115,000 ratings for Physician’s Choice 60 Billion Probiotic.
“Gentle probiotic that seems to work to keep me regular, and it doesn’t give me an upset stomach. The capsule is small enough that I have no trouble swallowing the pill. I like that there is no need for refrigeration and that you only need to take one pill daily.”
M. Cohen, Amazon
However, Rosalina S. didn’t notice a difference other than increased gas. She went on to say, “I don’t recommend it, but it might work for you, as everyone is different.”
Specs
| Dosage instructions | 1 capsule per day |
| Strains | 10 |
| CFUs | 60 billion |
| Servings per container | 3o |
| Cost per serving | $0.87 |
Best probiotic for IBS: Nature Made Digestive Probiotics Advanced Dual Action Capsules
Key product features
What you should know
Nature Made’s Digestive Probiotics Advanced Dual Action Capsules contain two probiotic strains that work simultaneously in the small and large intestines to counteract gut health issues.
- Although this probiotic claims to be free of preservatives, added color, and artificial flavors, we couldn’t identify that it was third-party tested for purity and quality.
- At $0.96 per serving, this probiotic is priced near the average of similar supplements on the market.
- This probiotic may be best for individuals who prefer to purchase supplements from recognized brands.
Why we like Nature Made Digestive Probiotics Advanced Dual Action Capsules as best for IBS
Irritable bowel syndrome (IBS) impacts approximately 10% to 15% of U.S. adults . The Nature Made Digestive Probiotics Advanced Dual Action Capsules is a vegetarian-friendly option with ingredients claimed to support the healthy gut flora in the small and large intestines.
This probiotic supplement only contains two key ingredients, both of which are strains of probiotics occasionally found in yogurt. Combined, there are 15 billion CFU per serving of Lactobacillus rhamnosus G.G. (LGG) and Bifidobacterium lactis HN019™ .
Research supports LGG ’s ability to aid other G.I. disorders like ulcerative colitis. ( 3 ) It may stimulate the immune system and butyrate-producing bacteria, which can help balance the microbiota and reduce intestinal inflammation. ( 3 )( 7 )
In a 2019 study, researchers found that LGG protected against dysfunction in the epithelial barrier, which keeps out harmful substances. ( 32 ) Epithelial barrier dysfunction is common among patients with IBS, causing pain and hypersensitivity. ( 33 ) Therefore, it’s possible that this strain may decrease IBS symptoms.
Research on Bifidobacterium lactis HN019™ also points to better bowel habits and improved stool consistency. ( 34 )
Nature Made recommends taking one capsule per day with a meal. The container includes 30 servings and must be kept in a cool, dry place. It costs $0.96 per serving and is averagely priced compared to other probiotic supplements.
These supplements are free of artificial flavors, preservatives, gluten, dairy, and added color. However, it isn’t third-party tested.
What customers are saying
On Amazon, customers share mainly positive reviews about the Nature Made Digestive Probiotics Advanced Dual Action Capsules.
Verified purchaser Wendy G. remarked that she loves these probiotics.
“Easy to swallow, and they have all the good stuff in them!”
Wendy G., Amazon
Another verified customer named Sherry stated, “This is my first experience with a probiotic. I read that the particular ingredients in this one are supposed to help with constipation. One a day was too much, at least at first, so I take one every other day.”
Specs
| Dosage instructions | 1 capsule per day |
| Strains | Two |
| CFUs | 15 billion CFU |
| Servings per container | 30 |
| Cost per serving | $0.96 |
Best probiotic for women: Hum Nutrition Private Party
Key product features
What you should know
Hum Nutrition Private party may optimize vaginal biome health and help reduce the frequency of UTIs and yeast infections.
- This supplement can be taken at any time of day but should be taken without food.
- At $0.87 per serving, Hum Nutrition Private Party is an average-priced probiotic in the marketplace.
- It’s best for women suffering from recurrent UTIs and vaginal symptoms who’ve tried other products but haven’t found relief.
- The nutrition label doesn’t provide the CFUs for the probiotics in this formula.
Why we like Hum Nutrition Private Party as best for women
Hum Nutrition designed Private Party specifically for women’s health. This non-GMO verified and Clean Label Project-certified supplement contains clinically-researched ingredients and is suitable for vegans.
Each serving includes 100 milligrams of three probiotic strains— Lactobacillus acidophilus , Lactobacillus rhamnosus , and Lactobacillus reuteri —and 90 milligrams of cranberry extract.
According to research, Lactobacillus is the most abundant microorganism in the vagina. ( 35 ) Lactobacillus is said to attach to the vaginal epithelium (protective layer) to combat pathogens which could then support immunity and improve the vaginal environment. ( 35 ) It may even help lower the risk of developing cervical cancer. ( 35 )
In addition, an older study on Lactobacillus rhamnosus and Lactobacillus reuteri proclaimed that they were the most effective strains at conserving and restoring normal vagina microbiota. ( 36 )
The cranberry extract in the Private Party formula may support urinary tract health. Research shows that cranberries may reduce the frequency of UTIs in women with recurrent UTI cases. ( 37 ) ( 38 )
For best results, you must take one Private Party delayed-release capsule daily. The bottle includes 30 servings and doesn’t require refrigeration. At $0.87 per serving, this probiotic supplement is one of the more affordable ones on the market.
What customers are saying
Based on Amazon reviews, most customers seem to be happy with their purchase.
Verified purchaser Kimberly G. stated, “I haven’t seen much benefit, but then again, I haven’t had a negative reaction to it either. So far, I have no complaints. Easy to take no aftertaste.”
Another verified Amazon buyer with the screen name Abk said it helped her with recurrent bacterial vaginosis (BV) infections. She wrote, “Before these, I got 2 B.V. infections within two months apart. After taking these, I went four months without getting another one. So, although these aren’t perfect, they have helped me go double the amount of time without getting this.”
Brie Kassel said, “It helped with smell and any itching you would normally have, but my urinary symptoms have not been great. It was the primary reason I bought it since so many people raved about how it helped. Guess it wasn’t for me.”
Specs
| Dosage instructions | 1 capsule per day |
| Strains | Three |
| CFUs | N/A |
| Servings per container | 30 |
| Cost per serving | $0.87 |
Best probiotic for inflammation: Bioma Probiotics
Key product features
What you should know
Provided in capsule form, the Bioma Probiotics formula includes research-backed ingredients that may have anti-inflammatory effects.
- Studies on the impact of probiotics on inflammation have mainly included animal subjects, so it’s challenging to say if those results will translate to humans.
- Bioma Probiotics are $1.87 per serving, which is above average for this type of supplement.
- It may be ideal for individuals with inflammatory conditions (with doctor approval) who want to alleviate this symptom.
- Two probiotics are meant to be taken before breakfast daily while on an empty stomach.
- If you’re a student, there’s a discount available.
Why we like Bioma Probiotics as best for inflammation
Inflammation is a common symptom associated with some chronic diseases. While supplements can’t cure them, products like Bioma Probiotics may reduce inflammation by replenishing the beneficial bacteria in your gut.
One serving of Bioma Probiotics contains 100 milligrams of xylooligosaccharide (XOS), 90 milligrams of Tributyrin, and 9 billion CFU of probiotics.
XOS is a prebiotic that may lower blood lipid levels, adjust blood glucose levels, and improve the intestinal ecosystem. ( 45 ) In a study involving patients with ulcerative colitis, XOS supplementation appeared to help with colonic inflammation. ( 46 ) It also stimulated the growth of some probiotics, like Bifidobacterium .
The proprietary blend of probiotics in this formula includes strains of Bifidobacterium lactis ,
Bifidobacterium longum , and Bifidobacterium breve .
Research suggests that the genus, Bifidobacterium , helps regulate immune homeostasis, and a deficit of it in the gut could lead to autoimmune issues. ( 47 ) A study on Bifidobacterium longum specifically revealed that it may prevent or treat inflammatory bowel disease by relieving chronic inflammation. ( 48 )
The postbiotic Tributyrin also has anti-inflammatory effects, as it releases butyric acid, a fatty acid that regulates inflammatory responses. ( 49 )
Bioma Probiotics come in capsule form, and you must take two before breakfast daily. The probiotics are third-party tested for efficacy and heavy metals and free of artificial additives. However, the product is manufactured in a facility that handles tree nuts, peanuts, soybeans, fish, and other potential allergens.
At $1.87 per serving, Bioma Probiotics are more expensive than similar options that offer a bit more. Additionally, the 14-day money-back policy pales compared to others, especially since the company says it may take 6-8 weeks to see results.
What customers are saying
On Amazon, Bioma Probiotics received mixed reviews. Many customers liked how easy it was to consume and noted changes in their weight.
Jillian Williams noted a big difference after taking them. She went on to say, “I don’t have sugar cravings, and my nails, skin, and hair look and feel much healthier.”
However, Verified purchaser R. Lee felt like the product worked in the beginning but then stopped. They said, “It did subdue some of my cravings. I wasn’t tempted to eat candies, cakes, and other sweets my coworkers had at work. I lost 7 lbs. Was it due to the capsules? Not sure.” After three months, the weight returned, and they made an update stating, “I wanted to give it more time. I’m three months in. No weight loss. Some gain. Normal eating patterns. After I finish this up, I’m not going to continue.”
Specs
| Dosage instructions | 2 capsules per day |
| Strains | Three |
| CFUs | 9 billion |
| Servings per container | 30 |
| Cost per serving | $1.87 |
How we test supplements
We recognize that probiotic supplements may play a crucial role in improving your physical and mental health. Our expert team is committed to helping you make an informed decision that aligns with your lifestyle preferences and health objectives. To learn more, you can review our full supplement testing methodology here.
Below is everything we look for when testing probiotic supplements:
Efficacy—40%
Consumers take dietary supplements to achieve specific goals and improve their overall wellbeing. That’s why our main focus when we evaluate protein powders is efficacy. Before recommending anything, we need to make sure a product delivers on its promised benefits.
Here’s what we look for when assessing efficacy:
- Clinical evidence
- Calories per serving
- Dose efficacy
- Synergistic effects
- Proprietary blends
Safety and side effects—35%
Our top priority is consumer safety. Before recommending a product, we examine its potential health risks, adverse effects, and safety profiles.
We evaluate:
- Reported side effects
- Third-party testing
- Manufacturer accreditation
- Artificial sweeteners
Value—20%
Value doesn’t just imply price—we look at a product’s value based on what you receive for the price you pay. Finding a high value protein powder doesn’t mean finding the cheapest option, but identifying a product that provides the health benefits, quality, efficacy, and satisfaction you’re looking for at a price that’s fair.
The main thing we look at in this rating is:
- Price per serving
Customer experience—5%
Customer experience can make or break how you feel about a product, and how likely you’ll be to buy that product again.
To evaluate customer experience we assess:
- Ease of purchase
- Shipping and returns
- Customer support
What are probiotics?
Probiotics are healthy bacteria found in yogurt, kefir, fermented foods like kimchi, pickles, and sauerkraut, fermented tea, called kombucha, fermented soy, and supplements.
What do probiotics do?
Probiotics are touted to help a variety of symptoms and conditions; diarrhea brought on by antibiotic use and gastrointestinal conditions like inflammatory bowel disease (IBD), to offset obesity and related metabolic disorders, type 2 diabetes, sepsis in preterm infants, colic in infants, allergies, skin issues like acne, and dental disease. Probiotics work by stimulating and adding to the good bacteria in the digestive tract. ( 1 )
Benefits of probiotics
Our gut microbiota is an ecosystem within the intestines that’s filled with good and potentially harmful microbes. When we’re healthy, these live microorganisms operate harmoniously and perform as intended. However, we may notice undesirable physiological changes when there’s a disbalance in the microbiome (dysbiosis) caused by antibiotics, illness, diet, or something else. ( 50 )
Fortunately, probiotics may help restore the system again and further maintain balance in the gut. Here are five benefits associated with using probiotic supplements.
Probiotics may improve common gastrointestinal symptoms
Research shows that probiotics may provide relief from constipation, diarrhea, and bloating. ( 27 , 34 , 40 ) Introducing probiotics can also help alleviate issues like nausea and vomiting, especially during pregnancy. ( 51 )
Probiotics may boost heart health
High blood cholesterol levels can increase your risk of heart disease and stroke. Some strains of probiotics have been shown to potentially lower blood cholesterol levels. ( 14 )
Probiotics may alleviate skin issues
Probiotics may improve skin diseases by reducing oxidative stress, suppressing inflammation, and maintaining a healthy immune system that obstructs pathogens. ( 52 ) Studies have shown that probiotics and prebiotics may help treat psoriasis and eczema cases. ( 53 , 54 )
Probiotics may strengthen the immune system
A robust immune system is necessary to help your body fight off infections and illnesses. Probiotics may help stimulate the immune system to better respond to pathogens. ( 55 ) Certain strains, like Bifidobacterium bifidum, have antibacterial and anti-inflammatory features that help stave off pathogens. ( 15 )
Probiotics may enhance cognitive abilities and mental health
An imbalanced gut may be associated with mental health conditions, and probiotics could be a safe and cost-effective treatment method. ( 56 ) For instance, in one study, older adults who received probiotic supplementation saw improved mental flexibility and stress. ( 57 ) Another study demonstrated that those with cognitive impairments and Alzheimer’s disease saw increased cognitive function following probiotic use. ( 58 )
Best probiotic foods
Probiotics are often found in fermented foods or beverages. Fermentation is a form of preservation in which foods are produced or changed using microbes.
Some fermented foods that are rich in probiotics include yogurt, sauerkraut, kefir, kimchi, pickles, miso, and tempeh. Even some unfermented foods, like cereal, have probiotics added.
What to look for in a probiotic
Today, there are tons of probiotic supplements on the market, and it’s not always clear what you should consider when buying them. When I first learned about probiotics, I knew I needed an easy way to consume them that I could remain consistent with. But I easily became overwhelmed with all of the available options. To save you the hassle I initially went through, here are the things I suggest you look for in a probiotic:
- Cost : A monthly supply of probiotics may cost $25 to $80. Some of the higher-priced ones also include essential nutrients and/or prebiotics and postbiotics.
- Form : Probiotic supplements usually come in capsules, powders, or gummies. Decide which form you’d prefer.
- Strains : Some probiotic strains are better suited for weight loss, while others are ideal for vaginal health. Aim for the ones that align with your needs and appear well-researched.
- Dosage instructions : Depending on the brand, one serving may equal two to three capsules. Some probiotics must also be taken before a meal or multiple times per day. You’ll need to determine if you can realistically follow the directions.
- Quantity of CFUs or AFUs : While nutritional labels may include the number of milligrams per serving for probiotics, it’s better to look at CFUs or AFUs. Those measurements tell you the number of bacteria you’ll get in each dose. AFUs include the quantity of dead and damaged microorganisms, while CFUs focus on the viable ones.
- Storage information : Many probiotics are shelf-stable, but some require refrigeration. If they are shelf-stable, keep them in a cool, dry place. Heat can kill bacteria over time, making the product less effective.
- Third-party testing : Unlike medications, brands don’t have to seek approval before distributing dietary supplements. Therefore, when businesses take the extra step to ensure their product doesn’t include unsafe levels of potentially harmful substances, it shows that they care about their consumers’ safety.
- Dietary restrictions : Many probiotics are vegan-friendly and free of common allergens, but some aren’t. If you have dietary restrictions, check the nutrition label to see if it includes ingredients you want to avoid.
Potential side effects of probiotics
When you first start taking probiotics, you may experience digestive discomfort like bloating, diarrhea, gas, and/or an upset stomach. In addition, certain probiotic strains may cause headaches.
Although rare, probiotics could trigger an allergic reaction, antibiotic resistance, or infection. Speak with your doctor to assess the risks versus benefits.
FAQs
What is the most effective form of probiotic?
Delayed-release probiotic capsules are often considered the best form of probiotics because they help protect essential nutrients. However, more research is needed to confirm this. Instead, it’s more important to focus on the specific probiotic strains and their benefits for your particular health condition.
Are probiotics actually worth it?
There’s evidence that probiotics may aid immune function and improve digestive, heart, and overall health. Some studies even demonstrate that probiotics may enhance cognitive functioning. In addition, the suggested benefits typically outweigh the few minor side effects associated with these supplements.
When is the best time to take probiotics?
There’s no specific time you should take probiotics, but you should check the product’s label to see if you should take it with food or on an empty stomach. To maintain consistency, it’s a good idea to take your probiotic at the same time each day. When starting a new probiotic, you may experience some G.I. discomfort, so it’s best to avoid taking a new-to-you probiotic while you’re away from the comfort of your own home.
How long does it take for probiotics to work?
It takes a few days—up to weeks—for probiotics to work, depending on your reason for taking them. If you are taking them to counteract the effects of an antibiotic, it should be a few days, but for a chronic condition, it may be longer for you to feel or see the benefits.
Who should not take a probiotic?
You should always speak with a healthcare professional before taking probiotic supplements. Those with a compromised immune system, certain gastrointestinal disorders, or severe illness should avoid probiotics unless their doctor approves.
What are the best probiotics recommended by doctors?
Physician’s Choice 60 Billion Probiotic has a doctor-approved formula. However, doctors often make specific recommendations based on patients’ signs and symptoms. If you’re unsure which direction to take, ask your physician for a safe and suitable option.
Are some probiotic strains better than others?
Each probiotic strain has features and benefits that may make it better equipped to improve certain symptoms or conditions than others. However, more research is needed to determine how they should be applied.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any diseases.
Our experts
Robert Wildman, Ph.D., RD, LD, CISSN, FISSN, Medical Reviewer
“Dr. Rob” is a globally renowned exercise, fitness, and nutrition expert who speaks around the world on exercise and sport nutrition, and continues to work with professional and elite athletes to achieve their highest level of performance as well as health and fitness. Rob received his Ph.D. from The Ohio State University, earned his MS from Florida State University, and earned his BS from the University of Pittsburgh. He is also a registered and licensed dietitian.
Kelly Uhler
Kelly has a multifaceted background in elder care, health care, and copywriting. She has worked for organizations such as A Place For Mom and Homecare.com, which gave her the opportunity to work closely with families, providing reliable information to help them make informed decisions about their loved one’s health, safety, and quality of life.
Amanda Dvorak, Editor
Amanda Dvorak is a Fortune Recommends™ writer and editor. A garage gym owner who is passionate about working out and healthy living, she has four years of experience writing product reviews for fitness and nutrition websites. Amanda is an ISSA certified personal trainer.
Jessica Coulon
Jessica Coulon is a contributing editor and writer for Fortune Recommends™ who specializes in fitness, health, nutrition, and science content. Previously, she was an editor for Popular Mechanics and Bicycling, where she covered pro cycling news, wrote how-to guides, and tested all the latest and greatest bike gear. She was also a regular shoe tester and contributor for Runner’s World. You can often find her skiing or riding her mountain bike, and racing with the F1RE female enduro team.
Jessica Thomas
Fortune Recommends Writer
About Author
Jessica Thomas is a health and wellness writer, public health professional, and business owner. She has a Bachelor of Science in Health Administration with a focus on Aging Studies. In addition, Jessica has earned a Master of Public Health with a minor in Public Health Informatics from Michigan State University.