Shead, K. D., Salyahetdinova, V. and Baillie, G. S. (2024) Charting the importance of Filamin A posttranslational modifications. Biochemical Journal, 481(13), pp. 865-881. (doi: 10.1042/BCJ20240121)
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Abstract
Filamin A is an essential protein in the cell cytoskeleton because of its actin binding properties and unique homodimer rod-shaped structure, which organises actin into three-dimensional orthogonal networks imperative to cell motility, spreading and adhesion. Filamin A is subject to extensive posttranslational modification (PTM) which serves to co-ordinate cellular architecture and to modulate its large protein-protein interaction network which is key to the protein's role as a cellular signalling hub. Characterised PTMs include phosphorylation, irreversible cleavage, ubiquitin mediated degradation, hydroxylation and O-GlcNAcylation, with preliminary evidence of tyrosylation, carbonylation and acetylation. Each modification and its relation to filamin A function will be described here. These modifications are often aberrantly applied in a range of diseases including, but not limited to, cancer, cardiovascular disease and neurological disease and we discuss the concept of target specific PTMs with novel therapeutic modalities. In summary, our review represents a topical ‘one-stop-shop’ that enables understanding of filamin A function in cell homeostasis and provides insight into how a variety of modifications add an extra level of Filamin A control.
Item Type: | Articles |
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Additional Information: | Kyle Shead is funded by British Heart Foundation grant FS/4yPhD/F/22/34180, George Baillie is funded by Medical Research Council grant (MR/y00364/1). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Shead, Mr Kyle and Baillie, Professor George |
Authors: | Shead, K. D., Salyahetdinova, V., and Baillie, G. S. |
College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Biochemical Journal |
Publisher: | Portland Press Ltd. |
ISSN: | 0264-6021 |
ISSN (Online): | 1470-8728 |
Published Online: | 03 July 2024 |
Copyright Holders: | Copyright © 2024 The Authors |
First Published: | First published in Biochemical Journal 481(13): 865-881 |
Publisher Policy: | Reproduced under a Creative Commons License |
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