Richardson, S. H., Mackenzie, J., Thekkethil, N., Feng, L., Lee, J., Berry, C. , Hill, N. , Luo, X. and Gao, H. (2024) Cardiac perfusion coupled with a structured coronary network tree. Computer Methods in Applied Mechanics and Engineering, 428, 117083. (doi: 10.1016/j.cma.2024.117083)
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Abstract
Sufficient myocardial perfusion plays a pivotal role in maintaining normal pump function. However the development of a comprehensive myocardial perfusion model remains particularly challenging as it requires the incorporation of complex interactions across different spatial scales and physical domains. In this study, we couple a coronary blood flow model to our previous work on a poroelastic immersed finite element framework for myocardial perfusion in a left ventricle (LV) heart. The coronary flow in the epicardial vessels is described by a 1-D flow model, and the intramural vessels are modelled as a structural tree-based vascular bed. The intramyocardial pressure resulting from myocardial contraction is further imposed on the coronary vessel wall. We first benchmark this coupled myocardial perfusion and coronary flow in a healthy heart. The systolic impediment phenomenon of the coronary flow can be reproduced with this coupled model, and the wall volume change is around 13 mL, which is consistent with literature-reported values. We further study cardiac perfusion under coronary network rarefaction, arterial wall stiffening and ventricular wall stiffening. Our results suggest that both vessel rarefaction and a stiffer arterial wall can directly impede flow through the coronaries leading to perfusion deficiency, and LV wall stiffening will impair heart pump function significantly but with a minor drop in coronary flow rate. It is expected that such a coupled myocardial perfusion and coronary flow model will have the potential to deepen our understanding of myocardial dysfunction due to perfusion deficiency.
Item Type: | Articles |
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Additional Information: | This research was supported by the UK Engineering and Physical Sciences Research Council (EP/N014642/1, EP/S030875, EP/S020950/1, EP/R511705/1, EP/X5257161/1), and the British Heart Foundation Project Grants (PG/22/10930, PG/14/64/31043, PG/11/2/28474, RE 18/6134217). |
Keywords: | Poroelasticity, fluid-structure interaction, heart perfusion, left ventricle, coronary flow, constitutive laws, arterial network, |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Berry, Professor Colin and Thekkethil, Mr Namshad and Mackenzie, Dr Jay and Gao, Dr Hao and Feng, Mr Liuyang and Luo, Professor Xiaoyu and Hill, Professor Nicholas and Richardson, Mr Scott |
Authors: | Richardson, S. H., Mackenzie, J., Thekkethil, N., Feng, L., Lee, J., Berry, C., Hill, N., Luo, X., and Gao, H. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Science and Engineering > School of Mathematics and Statistics College of Science and Engineering > School of Mathematics and Statistics > Mathematics |
Journal Name: | Computer Methods in Applied Mechanics and Engineering |
Publisher: | Elsevier |
ISSN: | 0045-7825 |
ISSN (Online): | 1879-2138 |
Published Online: | 08 June 2024 |
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