Buendia, R., Karpefors, M., Folkvaljon, F., Hunter, R., Sillen, H., Luu, L., Docherty, K. and Cowie, M. R. (2024) Wearable sensors to monitor physical activity in heart failure clinical trials: state-of-the-art review. Journal of Cardiac Failure, 30(5), pp. 703-716. (doi: 10.1016/j.cardfail.2024.01.016) (PMID:38452999)
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Abstract
Background: Estimation of the effects that drugs or other interventions have on patients’ symptoms and functions is crucial in heart failure trials. Traditional symptoms and functions clinical outcome assessments have important limitations. Actigraphy may help to overcome these limitations due to its objective nature and the potential for continuous recording of data. However, actigraphy is not currently accepted as clinically relevant by key stakeholders. Methods and Results: In this state-of-the-art study, the key aspects to consider when implementing actigraphy in heart failure trials are discussed. They include which actigraphy-derived measures should be considered, how to build endpoints using them, how to measure and analyze them, and how to handle the patients’ and sites’ logistics of integrating devices into trials. A comprehensive recommendation based on the current evidence is provided. Conclusion: Actigraphy is technically feasible in clinical trials involving heart failure, but successful implementation and use to demonstrate clinically important differences in physical functioning with drug or other interventions require careful consideration of many design choices.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Docherty, Dr Kieran |
Creator Roles: | |
Authors: | Buendia, R., Karpefors, M., Folkvaljon, F., Hunter, R., Sillen, H., Luu, L., Docherty, K., and Cowie, M. R. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Journal of Cardiac Failure |
Publisher: | Elsevier |
ISSN: | 1071-9164 |
ISSN (Online): | 1532-8414 |
Published Online: | 05 March 2024 |
Copyright Holders: | Copyright © 2024 The Authors |
First Published: | First published in Journal of Cardiac Failure 30(5):703-716 |
Publisher Policy: | Reproduced under a Creative Commons licence |
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