Casey, H., Dennehy, N., Fraser, A., Lees, C., McEniery, C. M., Scott, K. , Wilkinson, I. B. and Delles, C. (2023) Placental syndromes and maternal cardiovascular health. Clinical Science, 137(16), pp. 1211-1224. (doi: 10.1042/CS20211130) (PMID:37606085)
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Abstract
The placental syndromes gestational hypertension, preeclampsia and intrauterine growth restriction are associated with an increased cardiovascular risk to the mother later in life. In this review, we argue that a woman’s pre-conception cardiovascular health drives both the development of placental syndromes and long-term cardiovascular risk but acknowledge that placental syndromes can also contribute to future cardiovascular risk independent of pre-conception health. We describe how preclinical studies in models of preeclampsia inform our understanding of the links with later cardiovascular disease, and how current pre-pregnancy studies may explain relative contributions of both pre-conception factors and the occurrence of placental syndromes to long-term cardiovascular disease.
Item Type: | Articles |
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Additional Information: | This work has been supported by grants from Wellcome (221774/Z/20/Z). CD is supported by the British Heart Foundation (RE/18/6/34217). CCL is supported by the NIHR Biomedical Research Centre (BRC) based at Imperial College Healthcare NHS Trust and Imperial College London. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Casey, Dr Helen and Delles, Professor Christian and Scott, Dr Kayley and Wilkinson, Dr Ian |
Authors: | Casey, H., Dennehy, N., Fraser, A., Lees, C., McEniery, C. M., Scott, K., Wilkinson, I. B., and Delles, C. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | Clinical Science |
Publisher: | Portland Press |
ISSN: | 0143-5221 |
ISSN (Online): | 1470-8736 |
Published Online: | 22 August 2023 |
Copyright Holders: | Copyright © 2023 The Authors |
First Published: | First published in Clinical Science 137(16): 1211-1224 |
Publisher Policy: | Reproduced under a Creative Commons License |
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