Baillie, G. and Tibbo, A. (2020) Phosphodiesterase 4B: master regulator of brain signaling. Cells, 9(5), 1254. (doi: 10.3390/cells9051254) (PMID:32438615) (PMCID:PMC7291338)
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Abstract
Phosphodiesterases (PDEs) are the only superfamily of enzymes that have the ability to break down cyclic nucleotides and, as such, they have a pivotal role in neurological disease and brain development. PDEs have a modular structure that allows targeting of individual isoforms to discrete brain locations and it is often the location of a PDE that shapes its cellular function. Many of the eleven different families of PDEs have been associated with specific diseases. However, we evaluate the evidence, which suggests the activity from a sub-family of the PDE4 family, namely PDE4B, underpins a range of important functions in the brain that positions the PDE4B enzymes as a therapeutic target for a diverse collection of indications, such as, schizophrenia, neuroinflammation, and cognitive function.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Tibbo, Dr Amy and Baillie, Professor George |
Authors: | Baillie, G., and Tibbo, A. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Life Sciences |
Journal Name: | Cells |
Publisher: | MDPI |
ISSN: | 2073-4409 |
ISSN (Online): | 2073-4409 |
Published Online: | 19 May 2020 |
Copyright Holders: | Copyright © 2020 by the authors |
First Published: | First published in Cells 9(5):1254 |
Publisher Policy: | Reproduced under a Creative Commons license |
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