Anderson, J. J. , Darwis, N. D.M., Mackay, D. F. , Celis-Morales, C. , Lyall, D. M. , Sattar, N. , Gill, J. M.R. and Pell, J. P. (2018) Red and processed meat consumption and breast cancer: UK Biobank cohort study and meta-analysis. European Journal of Cancer, 90, pp. 73-82. (doi: 10.1016/j.ejca.2017.11.022)
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152842.pdf - Accepted Version 643kB |
Abstract
Aim: Red and processed meat may be risk factors for breast cancer due to their iron content, administration of oestrogens to cattle or mutagens created during cooking. We studied the associations in UK Biobank and then included the results in a meta-analysis of published cohort studies. Methods: UK Biobank, a general population cohort study, recruited participants aged 40–69 years. Incident breast cancer was ascertained via linkage to routine hospital admission, cancer registry and death certificate data. Univariate and multivariable Cox proportional hazard models were used to explore the associations between red and processed meat consumption and breast cancer. Previously published cohort studies were identified from a systematic review using PubMed and Ovid and a meta-analysis conducted using a random effects model. Results: Over a median of 7 years follow-up, 4819 of the 262,195 women developed breast cancer. The risk was increased in the highest tertile (>9 g/day) of processed meat consumption (adjusted hazard ratio [HR] 1.21, 95% confidence interval [CI] 1.08–1.35, p = 0.001). Collation with 10 previous cohort studies provided data on 40,257 incident breast cancers in 1.65 million women. On meta-analysis, processed meat consumption was associated with overall (relative risk [RR] 1.06, 95% CI 1.01–1.11) and post-menopausal (RR 1.09, 95% CI 1.03–1.15), but not pre-menopausal (RR 0.99, 95% CI 0.88–1.10), breast cancer. In UK Biobank and the meta-analysis, red meat consumption was not associated with breast cancer (adjusted HR 0.99 95% CI 0.88–1.12 and RR 1.03, 95% CI 0.99–1.08, respectively). Conclusions: Consumption of processed meat, but not red meat, may increase the risk of breast cancer.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Gill, Professor Jason and Anderson, Dr Jana and Mackay, Professor Daniel and Celis, Dr Carlos and Pell, Professor Jill and Sattar, Professor Naveed and Lyall, Dr Donald |
Authors: | Anderson, J. J., Darwis, N. D.M., Mackay, D. F., Celis-Morales, C., Lyall, D. M., Sattar, N., Gill, J. M.R., and Pell, J. P. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health |
Journal Name: | European Journal of Cancer |
Publisher: | Elsevier |
ISSN: | 0959-8049 |
ISSN (Online): | 1879-0852 |
Published Online: | 21 December 2017 |
Copyright Holders: | Copyright © 2017 Elsevier Ltd. |
First Published: | First published in European Journal of Cancer 90:73-82 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher. |
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