Published June 17, 2016
| Version 5
Dataset
Open
Human Lysine Demethylase JMJD1B (KDM3B); A Target Enabling Package
Description
There are 3 members of the Lysine Demethylase JMJD1 (KDM3) family, JMJD1A-C. SGC Oxford has expressed, purified and crystallized the catalytic domains of JMJD1A, JMJD1B and JMJD1C as part of the probe programme. Fragment screening and X-ray crystallography identified a large number of binders, some of which were progressed into a medicinal chemistry programme. Despite significant effort molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain.
Notes
Files
JMJD1B_TEP_datasheet_v5.pdf
Files
(1.5 MB)
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Additional details
Related works
- Is part of
- https://www.thesgc.org/tep (URL)