Abstract
The bed nucleus of the stria terminalis (BNST) is a heterogeneous and complex limbic forebrain structure, which plays an important role in controlling autonomic, neuroendocrine and behavioral responses. The BNST is thought to serve as a key relay connecting limbic forebrain structures to hypothalamic and brainstem regions associated with autonomic and neuroendocrine functions. Its control of physiological and behavioral activity is mediated by local action of numerous neurotransmitters. In the present review we discuss the role of the BNST in control of both autonomic and neuroendocrine function. A description of BNST control of cardiovascular and hypothalamus-pituitary-adrenal axisactivity at rest and during physiological challenges (stress and physical exercise) is presented. Moreover, evidence for modulation of hypothalamic magnocellular neurons activity is also discussed. We attempt to focus on the discussion of BNST neurochemical mechanisms. Therefore, the source and targets of neurochemical inputs to BNST subregions and their role in control of autonomic and neuroendocrine function is discussed in details.
Keywords: BNST, cardiovascular function, extended amygdala, neurotransmitters, HPA axis, vasopressin, stress and physical exercise
Current Neuropharmacology
Title:Mechanisms in the Bed Nucleus of the Stria Terminalis Involved in Control of Autonomic and Neuroendocrine Functions: A Review
Volume: 11 Issue: 2
Author(s): Carlos C. Crestani, Fernando H.F. Alves, Felipe V. Gomes, Leonardo B.M. Resstel, Fernando M.A. Correa and James P. Herman
Affiliation:
Keywords: BNST, cardiovascular function, extended amygdala, neurotransmitters, HPA axis, vasopressin, stress and physical exercise
Abstract: The bed nucleus of the stria terminalis (BNST) is a heterogeneous and complex limbic forebrain structure, which plays an important role in controlling autonomic, neuroendocrine and behavioral responses. The BNST is thought to serve as a key relay connecting limbic forebrain structures to hypothalamic and brainstem regions associated with autonomic and neuroendocrine functions. Its control of physiological and behavioral activity is mediated by local action of numerous neurotransmitters. In the present review we discuss the role of the BNST in control of both autonomic and neuroendocrine function. A description of BNST control of cardiovascular and hypothalamus-pituitary-adrenal axisactivity at rest and during physiological challenges (stress and physical exercise) is presented. Moreover, evidence for modulation of hypothalamic magnocellular neurons activity is also discussed. We attempt to focus on the discussion of BNST neurochemical mechanisms. Therefore, the source and targets of neurochemical inputs to BNST subregions and their role in control of autonomic and neuroendocrine function is discussed in details.
Export Options
About this article
Cite this article as:
Crestani C. Carlos, Alves H.F. Fernando, Gomes V. Felipe, Resstel B.M. Leonardo, Correa M.A. Fernando and Herman P. James, Mechanisms in the Bed Nucleus of the Stria Terminalis Involved in Control of Autonomic and Neuroendocrine Functions: A Review, Current Neuropharmacology 2013; 11 (2) . https://dx.doi.org/10.2174/1570159X11311020002
DOI https://dx.doi.org/10.2174/1570159X11311020002 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
![](https://cdn.statically.io/img/doi.org/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
- Forthcoming Thematic Issues
Related Articles
-
Carotid Artery Stenting for the Prevention of Thromboembolic Stroke
Vascular Disease Prevention (Discontinued) Proteomics and Mass Spectrometry: What Have We Learned About The Heart?
Current Cardiology Reviews C-Peptide and its Correlation to Parameters of Insulin Resistance in the Metabolic Syndrome
CNS & Neurological Disorders - Drug Targets Inspired Nitric Oxide and Modulation of Oxidative Stress During Cardiac Surgery
Current Drug Safety Obstetrical Hemorrhage Review
Current Women`s Health Reviews ACE Inhibition of Plant Alkaloids Targeted Approach for Selective Inhibition
Mini-Reviews in Organic Chemistry Exploring the Evidence Implicating the Renin-Angiotensin System (RAS) in the Physiopathology of Mood Disorders
Protein & Peptide Letters GC/MS Profile and <i>In-Vitro</i> α-Glucosidase Inhibitory Activity of Essential Oil of <i>Eucalyptus camaldulensis</i> Dehnh Collected from (Erbil) Iraq
Current Bioactive Compounds New Trends and Advances in Oral and Maxillofacial Imaging
Current Medical Imaging The Relationship Between Inflammation, Platelet Activation and Antiplatelet Resistance
Inflammation & Allergy - Drug Targets (Discontinued) Serum Proteomic Analysis of the Patients Suffering with End Stage Renal Disease and Left Ventricular Hypertrophy
Current Biomarkers (Discontinued) Renal and Hepatic Transporter Expression in Type 2 Diabetic Rats
Drug Metabolism Letters Bioactive Compounds of the PVPP Brewery Waste Stream and their Pharmacological Effects
Mini-Reviews in Organic Chemistry Tachykinins Play a Major Role in Micro and Macrovascular Complications in Type 2 Diabetes Patients
Current Diabetes Reviews Clinical Analysis of Resemblance and Dissimilarities of Glucagon-like Peptide-1 Receptor Agonists: Therapeutic Approach Towards the Management of Diabetes Mellitus
Current Drug Therapy Conference Proceedings: Second International Conference on Novel Psychoactive Substances (NPS) Swansea, UK; September 12-13th, 2013
Current Drug Abuse Reviews Pathophysiology and Prevention of Bronchopulmonary Dysplasia
Current Pediatric Reviews Blood Pressure Reduction in the Primary and Secondary Prevention of Stroke
Current Vascular Pharmacology Heme Oxygenase-1 in Vascular Smooth Muscle Cells Counteracts Cardiovascular Damage Induced by Angiotensin II
Current Neurovascular Research Non-Invasive Assessment of Non-Alcoholic Fatty Liver Disease: Ultrasound and Transient Elastography
Reviews on Recent Clinical Trials