3C-Based Chromatin Interaction Analyses
Abstract
This introduction presents a molecular approach that uses formaldehyde cross-linking to investigate genome structure and function—chromosome conformation capture (3C). This approach allows us to determine the spatial proximity of distant functional genomic sites (by looping). 3C-based techniques to interrogate chromosome folding and long-range interactions between genomic sequences in vivo are detailed.
Footnotes
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From the Molecular Cloning collection, edited by Michael R. Green and Joseph Sambrook.