Refined social phenotyping of syndromic and idiopathic forms of autism, combined with advances in genetics, animal models of syndromes and brain imaging, may facilitate discovery of shared brain mechanisms that will lead to new treatments. The reversal of social deficits in animal models is promising for eventual translation into therapeutics.
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References
Kanner, L. Nervous Child 2, 217–250 (1943).
Frankl, G. Nervous Child. 2, 251–262 (1943).
Wing, L. Psychol. Med. 11, 115–129 (1981).
Wing, L. J. Autism Dev. Disord. 35, 197–203 (2005).
Moss, J. & Howlin, P. J. Intellect. Disabil. Res. 53, 852–873 (2009).
Richards, C., Jones, C., Groves, L., Moss, J. & Oliver, C. Lancet Psychiatry 2, 909–916 (2015).
Harris, J.C. Am. J. Med. Genet. C. Semin. Med. Genet. 154C, 389–399 (2010).
Harris, J.C. in Textbook of Autism Spectrum Disorders (eds. Hollander, E., Kolevzon, A. & Coyle, J.T.) 223–237 (American Psychiatric Publishing, 2011).
Harris, J.C. Arch. Gen. Psychiatry 68, 230–231 (2011).
Gaugler, T. et al. Nat. Genet. 46, 881–885 (2014).
Samocha, K.E. et al. Nat. Genet. 46, 944–950 (2014).
Srivastava, S. et al. Am. J. Med. Genet. A. 164A, 1400–1410 (2014).
Hoeft, F. et al. Arch. Gen. Psychiatry 68, 295–305 (2011).
Krishnan, A., Kaza, R.K. & Vummidi, D.R. Radiol. Clin. North Am. 54, 423–440 (2016).
Overwater, I.E. et al. Eur. J. Hum. Genet. http://dx.doi.org/10.1038/ejhg.2016.85 (2016).
Naidu, S. et al. Brain Dev. 23 (Suppl. 1), S62–S71 (2001).
Lainhart, J.E. et al. J. Am. Acad. Child Adolesc. Psychiatry 36, 282–290 (1997).
Dolce, A., Ben-Zeev, B., Naidu, S. & Kossoff, E.H. Pediatr. Neurol. 48, 337–345 (2013).
Bolton, P.F., Park, R.J., Higgins, J.N.P., Griffiths, P.D. & Pickles, A. Brain 125, 1247–1255 (2002).
Hatton, D.D. et al. Am. J. Med. Genet. A. 140A, 1804–1813 (2006).
Hall, S.S., Lightbody, A.A., Hirt, M., Rezvani, A. & Reiss, A.L. J. Am. Acad. Child Adolesc. Psychiatry 49, 921–933 (2010).
Sztainberg, Y. & Zoghbi, H.Y. Nat. Neurosci. 19, 1408–1417 (2016).
Berry-Kravis, E. et al. Sci. Transl. Med. 8, 321ra5 (2016).
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Harris, J. The origin and natural history of autism spectrum disorders. Nat Neurosci 19, 1390–1391 (2016). https://doi.org/10.1038/nn.4427
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DOI: https://doi.org/10.1038/nn.4427
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