Abstract
The psycho-social development of both preterm and term children whose mothers reported tocolytic treatment was assessed at the ages of 2, 4.5, and 8 years. Term children exposed to tocolysis showed a higher rate of psychiatric disorders as well as poorer cognitive and motor perfomance than controls. In the preterm children no adverse impact of tocolysis could be found. The results are discussed concerning possible ways in which tocolytic treatment may influence child development. Restrictions because of the preliminary character of this study and the need of further prospective studies to clarify the developmental impact of tocolysis are also considered.
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Bocking AD: Preterm labour: recent advances in understanding of pathophysiology, diagnosis and management. Curr Opin Obstet Gynecol 10: 151–156, 1998.
Hoffman JD, Ward K: Genetic factors in preterm delivery. Obstet Gynecol Surv 54: 203–210, 1999.
Rutter M, Quinton D: Psychiatric disorder-ecological factors and concepts of causation. In Ecological factors in human development, ed. McGurk, M. Amsterdam: North-Holland, 1977.
Laucht M, Esser G, Schmidt MH: Developmental outcome of infants born with biological and psychosocial risks. J Child Psychol Psychiatry 38: 843–853, 1997.
Frydman M: The smoking addiction of pregnant women and the consequences of thrir offspring's intellectual development. J Environ Pathol Toxicol Oncol 15: 169–172, 1996.
Weissman MM, Warner V, Wickramaratne PJ, Kandel DB: Maternal smoking during pregnancy and psychopathology in offspring followed to adulthood. J Am Acad Child Adolesc Psychiatry 38: 892–899, 1999.
Grether JK, Nelson KB: Maternal infection and cerebral palsy in infants of normal birth weight. JAMA 278: 207–211, 1997.
Saigal S, Szatmari P, Rosenbaum P, Campbell D, King S: Cognitive abilities and school performance of extremely low birth weight children and matched term control children at age 8 years: a regional study. J Pediatr 118: 751–760, 1991.
Hack M, Klein NK, Taylor HG: Long-term developmental outcomes of low birth weight infants. Future Child 5: 176–196, 1995.
Hill WC. Risks and complications of tocolysis. Clin Obstet Gynecol 4: 725–745, 1995.
Polowczyk D, Tejani N, Lauersen N, Siddio F. Evaluation of seven-to nine-year-old children exposed to ritodrine in utero. Obstet Gynecol 64: 485–488, 1984.
Hadders-Algra M, Touwen BCL, Huisjes HJ. Long-term follow-up of children prenatally exposed to ritodrine. Br J Obstet Gynaecol 93: 156–161, 1986.
Gerhard I, Henninger T, von Holst B, Kubli F. Wehenhemmung mit Fenoterol. I. Prospektive Untersuchung zum Einfluβ der Tokolyse auf den Zustand des Neugeborenen und die frühkindliche Entwicklung bis zu vier Jahren. Z Geburtshilfe Perinatol 193: 29–41, 1989.
Casaer P. Old and new facts about perinatal brain development. J Child Psychol Psychiatry 34: 101–109, 1993.
Ciaranello RD, Aimi J, Dean RR, Morilak DA, Porteus MH Cicchetti D. Fundamentals of molecular neurobiology. In Developmental psychopathology, Vol. 1: Theory and Methods, eds. Cicchetti, D, Cohen, DJ. New York: John Wiley & Sons, 1995.
Esser G, Blanz B, Geisel, B: Laucht M: Mannheimer Elterninterview. Weinheim: Beltz, 1989.
Esser G, Schmidt MH, Woerner W: Epidemiology and course of psychiatric disorders in school-age children-results of a longitudinal study. J Child Psychol Psychiatry 31: 243–263, 1990.
Bayley N: Bayley Scales of Infant Development. New York: Psychological Corporation, 1969.
Köhler G, Egelkraut H: Münchener Funktionelle Entwicklungsdiagnostik für das 2. Und 3. Lebensjahr. Handanweisung Vorabdruck. München: Institut für Soziale Pädiatrie und Jugendmedizin der Universität, 1984.
Burgemeister B, Blum L, Lorg J: Columbia Mental Maturity Scale. New York: Harcourt Brace Jovanovich, 1972.
Kirk SA, McCarthy J, Kirk WD: Illinois Test of Psycholinguistic Abilities. Urbana, IL: University of Illinois Press, 1968.
Cattell RB: Handbook for the culture fair intelligence test, scale 1. Urbana, IL: University of Illinois Press, 1966.
Kaufman AS, Kaufman NL: Kaufman Assessment Battery for Children. Circle Pines, MN: American Guidance Service, 1983.
Linder M, Grissmann H: Zürcher Lesetest. Bern: Huber, 1996.
Peh D, Rathenow P: Test Grundanforderungen Rechtschreibung für die 1. und 2. Klasse. Weinheim: Beltz, 1984.
Müller R: Diagnostischer Rechtschreibtest für die 2. Klasse. Weinheim: Beltz, 1990.
Müller R: Diagnostischer Rechtschreibtest für die 3. Klasse. Weinheim: Beltz, 1994.
Touwen BCL, Prechtl HFR: The neurological examination of the child with minor nervous dysfunction. London: Heinemann, 1970.
Zimmer R, Volkamer M: Motoriktest für vier-bis sechsjährige Kinder. Weinheim: Beltz, 1985.
Kiphard EJ, Schilling F: Körperkoordinationstest für Kinder. Weinheim: Beltz, 1974.
Keller CA: Epidemiological characteristics of preterm birth. In Preterm birth and psychological development, ed. Friedman SL. New York: Academic Press, Inc., 1981.
Costeff H, Kulikowski Z: The developmental profile of disadvantaged 6 year old children. Br J Dev Disabil 42: 45–53, 1996.
Sonnander K, Claesson M: Predictors of developmental delay at 18 months and later school achievement problems. Dev Med Child Neurol 41: 195–202, 1999.
Siegel LS: Reproductive, perinatal, and environmental factors as predictors of the cognitive and language development of preterm and full-term infants. Child Dev 53: 963–973, 1983.
Largo RH, Molinari L, Comenale Pinto L, Weber M, Duc G: Language development of term and preterm children during the first five years of live. Dev Med Child Neurol 28: 333–350, 1986.
American Academy of Child and Adolescent Psychiatry (AACAP): Practice Parameters for the assessment and treatment of children and adolescents with language and learning disorders. J Am Acad Child Adolesc Psychiatry 37 (Suppl): 46S-62S, 1998.
Eley TC, Bishop DV, Dale PS, Oliver B, Petrill, SA, Price TS, Purcell S, Saudino, KJ, Simonoff E, Stevenson J, Plomin R: Genetic and environmental origins of verbal and performance components of cognitive delay in 2–year-olds. Dev Psychol 35: 1122–1131, 1999.
Esser G, Schmidt MH: Children with specific reading retardation-early determinants and long-term outcome. Acta Paedopsychiatr 56: 229–237, 1994.
Taylor DJ, Howie PW, Davidson J, Davidson D, Drillien CM: Do pregnancy complications contribute to neurodevelopmental disability? Lancet 1(8431): 713–716, 1985.
Curran T. The fos oncogene. In The oncogene handbook, eds. Reddy EP, Skalka AM, Curran T. Amsterdam: Elsevier, 1988.
Barka T, van der Noen H, Shaw PA: Proto-oncogene fos (c-fos) expression in the heart. Oncogene 1:439–443, 1987.
Slotkin TA, Lappi SE, Seidler FJ: β-Adrenergic control of c-fos expression in fetal and neonatal rat tissues: Relationship to cell differentiation and teratogenesis. Toxicol Appl Pharmacol 133: 188–195, 1995.
Wagner JP, Seidler FJ, Schachat FH, Slotkin TA: Beta adrenergic control of c-fos protooncogene expression in developing rat brain regions. J Pharmacol Exp Ther 269: 1292–1299, 1994.
Huang C-C, Hsu K-S, Gean P-W: Isoproterenol potentiates synaptic transmission primarily by enhancing presynaptic calcium influx via P-and/ or Q-type calcium channels in the rat amygdala. J Neurosci 16: 1026–1033, 1996.
Watanabe Y, Ikegaya Y, Saito H, Abe K: Opposite regulation by the β-adrenoceptorcyclic AMP system of synaptic plasticity in the medial and lateral amygdala in vitro. Neuroscience 71: 1031–1035, 1996.
Tallal P, Merzenich MM, Miller S, Jenkins W: Language learning impairments: integrating basic science, technology, and remediation. Exp Brain Res 123: 210–219, 1998.
Alvarez M, Pita S, Costas E, Cupeiro A, Chaves OF Garcia M, Sola A, Goyanes V. Long term effects of ritodrine on blood pressure and heart rate of adolescents exposed during the prenatal stage. Eur J Obstet Gynecol Reprod Biol 59: 137–141, 1995.
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Pitzer, M., Schmidt, M.H., Esser, G. et al. Child Development After Maternal Tocolysis with Beta-Sympathomimetic Drugs. Child Psychiatry Hum Dev 31, 165–182 (2001). https://doi.org/10.1023/A:1026419720410
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DOI: https://doi.org/10.1023/A:1026419720410