Abstract
Aging is associated with decline in cardiovascular, autonomic function, and brain-derived neurotropic factor (BDNF). Reports are scanty regarding whether yoga can improve age-related degenerative changes in healthy active men. This study is designed to appraise the role of yoga in improving age-related degenerative changes in cardiometabolic risk profile, autonomic function, stress, and BDNF. Healthy active males of three age groups (20–29, 30–39, and 40–49 years) were randomly assigned to practice yoga daily 1 h for 3 months. Significantly higher values of heart rate (HR), blood pressure (BP), load in heart (DoP), myocardial oxygen consumption (RPP), and total cholesterol (TC) were noted in senior age group. HR, BP, DoP, RPP, and TC decreased significantly following yogic practice. High frequency (HF), total power (TP), all time domain variables of heart rate variability (HRV), and skin conductance (SC) were significantly decreased with advancement of age. HF, TP, and time domain parameters of HRV and SC increased significantly following yogic practice. Higher levels of catecholamines and low frequency (LF) power of HRV was noted with advancement of age. Levels of catecholamines and LF significantly decreased following yogic practice. Cortisol and adrenocorticotropic hormone (ACTH) level raised in senior age group. BDNF, serotonin, and dopamine were low in higher age group. Significant decrement of cortisol; ACTH; and increment in serotonin, dopamine, and BDNF was noted following yogic practice. This study revealed that yogic practices might help in the prevention of age-related degeneration by changing cardiometabolic risk factors, autonomic function, and BDNF in healthy male.
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References
Acheson A (1995) BDNF autocrine loop in adult sensory neurons prevents cell death. Nature 374:450–453
Alexeyev MF, Ledoux SP, Wilson GL (2004) Mitochondrial DNA and aging. Clin Sci 107:355–364
Barontini M, Lázzari JO, Levin G, Armando I, Basso SJ (1997) Age-related changes in sympathetic activity: biochemical measurements and target organ responses. Arch Gerontol Geriatr 25(2):175–186
Beck LH (1998) Changes in renal function with aging. Clin Geriatr Med 14:199–209
Bekaert S, De Meyer T, Van Oostveldt P (2005) Telomere attrition as ageing biomarker. Anticancer Res 25:3011–3021
Bera TK, Rajapurkar MV (1993) Body composition, cardiovascular endurance and anaerobic power of yogic practitioner. Indian J Physiol Pharmacol 37:225–228
Botwinick J, Kornetsky C (1960) Age differences in the acquisition and extinction of the GSR. J Gerontol 15:83–84
Bowman AJ, Clayton RH, Murray A et al (1997) Effects of aerobic exercise training and yoga on the baroreflex in healthy elderly persons. Eur J Clin Investig 27:443–449
Burzynski SR (2005) Aging: gene silencing or gene activation. Med Hypotheses 64:201–208
Cacioppo JT, Berntson GG, Klein DJ, Poehlmann KM (1997) The psychophysiology of emotion across the lifespan. Annu Rev Gerontol Geriatr 17:27–74
Chung SC, Brooks MM, Rai M, Balk JL, Rai S (2012) Effect of sahaja yoga meditation on quality of life, anxiety, and blood pressure control. J Altern Complement Med 18:589–596
Delmonte MM (1985) Biochemical indices associated with meditation practice. A literature review. Neurosci Biobehav Rev 9:557–561
Dreher J, Meyer-Lindenberg A, Kohn P, Berman KF (2008) Age-related changes in midbrain dopaminergic regulation of the human reward system. PNAS 105:3915106–3915111
Eckberg D (1997) Sympathovagal balance: a critical appraisal. Circulation 96:3224–3232
Erickson KI, Prakash RS, Voss MW, Chaddock L, Heo S, McLaren M, Pence BD, Martin SA, Vieira VJ, Woods JA, McAuley E, Kramer AF (2010) Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume. J Neurosci 30(15):5368–5375. doi:10.1523/JNEUROSCI.6251-09.2010
Essig F, Sinclair D, Hare J, Moreillon J, Funk D, Swank AM (2004) Cross-sectional analysis of cardiovascular factors for participants of a university faculty and staff wellness program. J Exerc Physiol 7:37–43
Fagard RH (2001) A population-based study on the determinants of heart rate and heart rate variability in the frequency domain. Verh K Acad Geneeskd Belg 63(1):57–89
Fahri A (2010) Changes in serum lipid profile following moderate exercise. Afr J Pharm Pharmacol 4(11):829–833
Farley A, McLafferty E, Hendry C (2006) The physiological effects of ageing on the activities of living. Nurs Stand 20:46–52
Field T (2011) Yoga clinical review. Complement Ther Clin Pract. doi:10.1016/j.ctcp.2010.09.007
Fraser R, Ingram MC, Anderson NH, Morrison C, Davies E, Connell JMC (1999) Cortisol effects on body mass, blood pressure, and cholesterol in the general population. Hypertension 33:1364–1368
Frisard M, Ravussin E (2006) Energy metabolism and oxidative stress: impact on the metabolic syndrome and the aging process. Endocrine 29:27–32
Froeliger BE, Garland EL, McClernon FJ (2012) Yoga meditation practitioners exhibit greater gray matter volume and fewer reported cognitive failures: results of a preliminary voxel-based morphometric analysis. Evid Based Complement Alternat Med. doi:10.1155/2012/821307
Garau C, Aparicio S, Rial RV, Nicolau MC, Esteban S (2006) Age-related changes in circadian rhythm of serotonin synthesis in ring doves: effects of increased tryptophan ingestion. Exp Gerontol 41(1):40–48
Gobel FL, Nordstrom LA, Nelson RR, Jorgenson CR, Wang Y (1978) The rate pressure product as an index of myocardial oxygen consumption during exercise in patient with angina pectoris. Circulation 57:549–556
Gordon LA, Morrison EY, McGrowder DA, Young R, Fraser YT, Zamora EM et al (2008) Effect of exercise therapy on lipid profile and oxidative stress indicators in patients with type 2 diabetes. BMC Complement Alternat Med 8:21
Gothe N, Pontifex MB, Hillman C, McAuley E (2013) The acute effects of yoga on executive function. J Phys Act Health 10:488–495
Huang EJ, Reichardt LF (2001) Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24:677–736
Huang FJ, Chien DK, Chung UL (2013) Effects of Hatha yoga on stress in middle-aged women. J Nurs Res 21(1):59–66
Jensen-Ustad K, Strock N, Bouvier F, Ericson M, Lindblad LE, Jensen-Ustad M (1997) Heart rate variability in healthy subjects is related to age and gender. Acta Physiol Scand 160:235–241
Kirk-Sanchez NJ, McGough EL (2014) Physical exercise and cognitive performance in the elderly: current perspectives. Clin Interv Aging 9:51–62
Kumar K, Joshi B (2009) Study on the effect of Pranakarshan pranayama and Yoga nidra on alpha EEG & GSR. Indian J Tradit Knowl 8:453–454
Kuo TB et al (1999) Effect of aging on gender differences in neural control of heart rate. Am J Physiol 277:H2233–H2239
Kuzina IN, Kilikovskiĭ VV, Smirnova OV (2010) Age-related changes in blood concentration of hypothalamic-pituitary-adrenal axis hormones, their central and peripheral regulators in healthy men. Fiziol Cheloveka 36(5):101–109
Landahl S, Bengtsson C, Sigurdsson JA, Svanborg A, Svärdsudd K (1986) Age-related changes in blood pressure. Hypertension 8:1044–1049
Leosco D, Parisi V, Femminella GD, Formisano R, Petraglia L, Allocca E, Bonaduce D (2013) Effects of exercise training on cardiovascular adrenergic system. Front Physiol 4:348
Lommatzsch M, Zingler D, Schuhbaeck K, Schloetcke K, Zingler C, Schuff-Werner P, Virchow JC (2005) The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiol Aging 26:115–123
Madanmohan, Kaviraja U, Bhavanani AB, Vijayalakshmi P, Surendiran A (2005) Effects of slow and fast pranayams on reaction time and Cardiorespiratory variables. Indian J Physiol Pharmacol 49:313–318
Malaguarnera M, Giugno I, Ruello P, Rizzo M, Panebianco MP, Pistone G, Omasello FB (1998) Lipid profile variations in a group of healthy elderly and centenarians. Eur Rev Med Pharmacol Sci 2:75–79
Malliani A, Pagani M, Furlan R, Guzzetti S, Lucini D, Montano N et al (1997) Individual recognition by heart rate variability of two different autonomic profiles related to posture. Circulation 96:4143–4145
Massin MM, Derkenne B, von Bernuth G (1999) Correlations between indices of heart rate variability in healthy children with congenital heart disease. Cardiology 91:109–113
Muhlberg W, Platt D (1999) Age-dependent changes of the kidneys: pharmacological implications. Gerontology 45:243–253
Murugesan R, Govindarajulu N, Bera TK (2000) Effect of selected yogic practices on the management of hypertension. Indian J Physiol Pharmacol 44:207–210
Naveen GH, Thirthalli J, Rao MG, Varambally S, Christopher R, Gangadhar BN (2013) Positive therapeutic and neurotropic effects of yoga in depression: a comparative study. Indian J Psychiatry 55(Suppl3):S400–S404. doi:10.4103/0019-5545.116313
Oken BS, Kishiyama S, Zajdel D et al (2004) Randomized controlled trial of yoga and exercise in multiple sclerosis. Neurology 62:2058–2064
Oken BS, Zajdel D, Kishiyama S et al (2006) Randomized controlled, six-month trial of yoga in healthy seniors: effects on cognition and quality of life. Altern Ther Health Med 12:40–47
Panjwani U, Gupta H, Singh SH, Selvamurthy W, Rai UC (1995) Effect of Sahaja Yoga practice on stress management in patients of epilepsy. Indian J Physiol Pharmacol 39:111–116
Papp ME, Lindfors P, Storck N, Wändell PE (2013) Increased heart rate variability but no effect on blood pressure from 8 weeks of hatha yoga—a pilot study. BMC Res Notes. doi:10.1186/1756-0500-6-59
Patil SP, Telles S (2006) Changes in heart rate variability during and after two yoga based relaxation techniques. Int J Stress Manag 13:460–473
Ray US, Mukhopadhyaya S, Purkayastha SS, Asnani V, Tomer OS, Prashad R, Thakur L, Selvamurthy W (2001) Effect of yogic exercises on physical and mental health of young fellowship course trainees. Indian J Physiol Pharmacol 45:37–53
Reardon M, Malik M (1996) Changes in heart rate variability with age. Pacing Clin Electrophysiol. doi:10.1111/j.1540-8159.1996.tb03241.x
Relsln E, Abe R, Modan M, Sllverberg OS, Ellahou HE, Modan B (1978) Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patients. N Engl J Med 298:1–6
Sahay BK (2007) Role of yoga in diabetes. J Assoc Physicians India 55:121–126
Selvamurthy W, Ray US, Hedge KS, Sharma RP (1988) Physiological responses to cold (100 °C) in men after six months’ practice of yoga exercises. Int J Biometeorol 32:188–193
Selvamurthy W, Sridharan K, Ray US, Tiwary RS, Hegde KS, Radhakrishan U, Sinha KC (1998) A new physiological approach to control essential hypertension. Indian J Physiol Pharmacol 42:205–213
Shimazu T, Tamura N, Shimazu K (2005) Aging of the autonomic nervous system. Nihon Rinsho 63(6):973–977
Singh S, Kyizom T, Singh KP, Tandon OP, Madhu SV (2008) Influence of pranayamas and yoga—asanas on serum insulin, blood glucose and lipid profile in type 2 diabetes. Indian J Clin Biochem 23:365–368
Sinha S, Singh SN, Monga YP, Ray US (2007) Improvement of glutathione and total antioxidant status with yoga. J Altern Complement Med 13(10):1085–1090. doi:10.1089/acm.2007.0567
Smith C, Hancock H, Blake Mortimer J, Eckert K (2007) A randomized comparative trial of yoga and relaxation to reduce stress and anxiety. Complement Ther Med 15:77–83
Smith JA, Greer T, Sheets T, Watson S (2011) Is there more to yoga than exercise? Altern Ther Health Med 17(3):22–29
Stamier R, Stamler J, Rledllnger WF, Algera G, Roberts RH (1978) Weight and blood pressure. Findings in hypertension screening of 1 million Americans. JAMA 240:1607–1610
Steen B (2001) Biological aging—a mini review. Lakartidningen 98:1924–1928
Tapp LR, Signorile JF (2014) Efficacy of WBV as a modality for inducing changes in body composition, aerobic fitness, and muscular strength: a pilot study. Clin Interv Aging 9:63–72
Terman A (2006) Catabolic insufficiency and aging. Ann N Y Acad Sci 1067:27–36
Tulpule TH, Shah HM, Shah SJ, Haveliwala HK (1971) Yogic exercises in the management of ischaemic heart disease. Indian Heart J 23(4):259–264
Viña J, Borrás C, Miquel J (2007) Theories of ageing. IUBMB Life 59:249–254
Woodworth RS, Schlosberg H (1971) In: Kling JW, Rigg LA (eds) Experimental psychology. Rinehart and Winston, New York
Xiong GL, Doraiswamy PM (2009) Does meditation enhance cognition and brain plasticity? Ann N Y Acad Sci 1172:63–69
Yonezawa Y, Kondo H, Nomaguchi TA (1989) Age-related changes in serotonin content and its release reaction of rat platelets. Mech Ageing Dev 47(1):65–75
Yurkuran M, Alp A, Yurtkuran M, Dilek K (2007) A modified yoga based exercise program in hemodialysis patients: A randomized control study. Complement Ther Med 15:164–171
Zhang J (2007) Effect of age and sex on heart rate variability in healthy subjects. J Manipulative Physiol Ther 30(5):374–379
Acknowledgments
The authors express their sincere gratitude to the Director, Defence Institute of Physiology and Allied Sciences (DIPAS), Delhi, for giving the necessary permission to conduct this study. Additionally, the authors are grateful to the Director, Morarji Desai National Institute of Yoga (MDNIY), Delhi, for the continuous support to the study. Moreover, the authors also acknowledge the support of the Project Director, CARTY for giving necessary permission, encouragement, and moral support. The authors acknowledge the support of a yoga instructor. A warm thanks is due to all volunteers who participated in the study, without whose willing and wholehearted cooperation this study would not have been possible, and, finally, to the concerned officials for providing all facilities required for a smooth conduction of the trial.
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The authors declare that there is no actual or potential conflict of interest regarding this study.
Ethical standards
All the experiments comply with the current laws of the country and approved by the Institutional Ethical Committee, DIPAS, Delhi, India.
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Pal, R., Singh, S.N., Chatterjee, A. et al. Age-related changes in cardiovascular system, autonomic functions, and levels of BDNF of healthy active males: role of yogic practice. AGE 36, 9683 (2014). https://doi.org/10.1007/s11357-014-9683-7
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DOI: https://doi.org/10.1007/s11357-014-9683-7