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Evaluation of IL-10, IFN-γ, and thiol–disulfide homeostasis in patients with drug-resistant epilepsy

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Abstract

Aim

This study compared dynamic thiol���disulfide homeostasis (an oxidative stress marker), anti-inflammatory interleukin-10 (IL-10) levels, and proinflammatory interferon gamma (IFN-γ) levels in drug-resistant epilepsy patients with those in patients with well-controlled epilepsy and healthy controls.

Method

This prospective cross-sectional study enrolled 89 people: 27 with drug-resistant epilepsy, 30 with well-controlled epilepsy, and 32 healthy controls matched in demographic characteristics.

Results

The mean serum IL-10 levels were significantly lower and the mean serum IFN-γ levels significantly higher in the drug-resistant epilepsy patients compared to the well-controlled epilepsy and healthy control groups. The mean serum native thiol (SH) and total thiol (TT) levels were significantly lower, and the disulfide (SS) levels were significantly higher in the drug-resistant group than in the other two groups.

Conclusions

The significant differences in thiol–disulfide homeostasis and IL-10 and IFN-γ levels in the drug-resistant epilepsy group suggest that these markers indicate a poor prognosis in epilepsy.

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Author information

Authors and Affiliations

  1. Department of Neurology, Balikesir University, Pasakoy, Bigadic yolu üzeri Merkez/Altıeylul/Balikesir, 10145, Balıkesir, Turkey

    Mehtap Kocatürk

  2. Department of Biochemistry, Harran University, Sanlıurfa, Turkey

    Adnan Kirmit

Authors
  1. Mehtap Kocatürk
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  2. Adnan Kirmit
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Mehtap Kocatürk and Adnan Kirmit. The first draft of the manuscript was written by Mehtap Kocatürk, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Mehtap Kocatürk.

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Conflict of interest

The authors declare no competing interests.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Bioethics Committee of the Medical Faculty of Harran University (No: 17/01/2019-E.2426).

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Informed consent was obtained from all individual participants included in the study.

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Kocatürk, M., Kirmit, A. Evaluation of IL-10, IFN-γ, and thiol–disulfide homeostasis in patients with drug-resistant epilepsy. Neurol Sci 43, 485–492 (2022). https://doi.org/10.1007/s10072-021-05331-x

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  • DOI: https://doi.org/10.1007/s10072-021-05331-x

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