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Prevention or acceleration of type 1 diabetes by viruses

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An Erratum to this article was published on 30 October 2012

Abstract

Type 1 diabetes is an autoimmune disease characterized by the destruction of insulin-producing pancreatic β-cells. Even though extensive scientific research has yielded important insights into the immune mechanisms involved in pancreatic β-cell destruction, little is known about the events that trigger the autoimmune process. Recent epidemiological and experimental data suggest that environmental factors are involved in this process. In this review, we discuss the role of viruses as an environmental factor on the development of type 1 diabetes, and the immune mechanisms by which they can trigger or protect against this pathology.

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Acknowledgments

We apologize to all the authors whose work we could not cite owing to space constrictions. This work was supported by funds from the Institut National de la Santé et de la Recherche Médicale and the Centre National pour la Recherche Scientifique, grant from ANR-09-GENO-023 and LABEX INFLAMEX to AL. Liana Ghazarian and Yannick Simoni were supported by doctoral fellowships from the Ministère de l'Education Nationale et de la Recherche et Technique and from Région Île-de-France.

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  1. Hôpital Saint Vincent de Paul/Cochin, Batiment Petit, 82 Avenue Denfert-Rochereau, 75014, Paris, France

    Liana Ghazarian, Julien Diana, Yannick Simoni, Lucie Beaudoin & Agnès Lehuen

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  1. Liana Ghazarian
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  2. Julien Diana
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  3. Yannick Simoni
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  4. Lucie Beaudoin
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  5. Agnès Lehuen
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Correspondence to Liana Ghazarian or Agnès Lehuen.

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Ghazarian, L., Diana, J., Simoni, Y. et al. Prevention or acceleration of type 1 diabetes by viruses. Cell. Mol. Life Sci. 70, 239–255 (2013). https://doi.org/10.1007/s00018-012-1042-1

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  • DOI: https://doi.org/10.1007/s00018-012-1042-1

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