Abstract
Repetitive and restricted behaviors and interests (RRBI’s) described in individuals with Autism Spectrum Disorder (ASD) and defined in the DSM-5 criteria are diverse. They encompass repetitive behaviors, such as stereotyped motor movements, repetitive manipulation of objects, repetitive and stereotyped language, repetitive sensory behaviors and insistence on sameness. Many theories regarding the neurological mechanisms underlying RRBI’s in ASD have been suggested, ranging from psychological, structural and anatomical abnormalities to molecular and genetic impairments. In this chapter we elaborate on some of the leading theories concerning the neurological basis of RRBI’s in ASD.
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References
Abbott, A. E., Linke, A. C., Nair, A., Jahedi, A., Alba, L. A., Keown, C. L., et al. (2018). Repetitive behaviors in autism are linked to imbalance of corticostriatal connectivity: A functional connectivity MRI study. Social Cognitive and Affective Neuroscience, 13(1), 32–42. https://doi.org/10.1093/scan/nsx129.
Abrahams, B. S., & Geschwind, D. H. (2009). Advances in autism genetics: On the threshold of a new neurobiology. Nature Reviews Genettics, 9(5), 341–355. https://doi.org/10.1038/nrg2346.Advances.
Albin, R. L., Young, A. B., Penney, J. B., Roger, L. A., & Young, B. B. (1989). The functional anatomy of basal ganglia disorders. Trends in Neurosciences, 12(10), 366–375.
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Retrieved from https://www.autismspeaks.org/what-autism/diagnosis/dsm-5-diagnostic-criteria.
Anagnostou, E., Soorya, L., Chaplin, W., Bartz, J. A., Halpern, D., Wasserman, S., et al. (2012). Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: A randomized controlled trial. Molecular Autism, 3(1), 16. https://doi.org/10.1186/2040-2392-3-16.
Anthony, B., Luthert, P., Bolton, P., Le Couteur, A., Rutter, M., & Harding, B. (1989). Autism and Megalencephaly. The Lancet, 341, 1225–1226.
Barnby, G., Abbott, A., Sykes, N., Morris, A., Weeks, D. E., Mott, R., et al. (2005). Candidate-gene screening and association analysis at the autism-susceptibility locus on chromosome 16p: Evidence of association at GRIN2A and ABAT. American Journal of Human Genetics, 76(6), 950–966.
Baron-Cohen, S. (1989). Do autistic children have obsessions and compulsions? British Journal of Clinical Psycology, 28(3), 193–200.
Bishop, S. L., Hus, V., Duncan, A., Huerta, M., Gotham, K., Pickles, A., et al. (2013). Subcategories of restricted and repetitive behaviors in children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 43(6), 1287–1297. https://doi.org/10.1007/s10803-012-1671-0.
Bishop, S. L., Richler, J., & Lord, C. (2006). Association between restricted and repetitive behaviors and nonverbal IQ in children with Autism Spectrum Disorders. Child Neuropsychology, 12(4–5), 247–267. https://doi.org/10.1080/09297040600630288.
Bittel, D. C., & Butler, M. G. (2005). Prader – Willi syndrome: Clinical genetics, cytogenetics and molecular biology. Expert Reviews in Molecular Medicine, 7(14), 1–20. https://doi.org/10.1017/S1462399405009531.
Bodfish, J. W., Symons, F. J., Parker, D. E., & Lewis, M. H. (2000). Varieties of repetitive behaviour in autism: Comparison to mental retardation. Journal of Autism and Developmental Disorders, 30(3), 237–243. https://doi.org/10.1023/A:1005596502855.
Boyer, P., & Lie’nard, P. (2006). Why ritualized behavior? Precaution Systems and action parsing in developmental, pathological and cultural rituals. Behavioral and Brain Science, 29, 595–650. https://doi.org/10.1017/S0140525X06009332.
Buchsbaum, M. S., Hazlett, E. A., Ph, D., Licalzi, E. M., Cartwright, C., & Hollander, E. (2006). Volumetric analysis and three-dimensional glucose metabolic mapping of the striatum and thalamus in patients with autism spectrum disorders. American Journal of Psychiatry, 163(7), 1252–1263.
Cantor, R. M., Navarro, L., Won, H., Walker, R. L., Lowe, J. K., & Geschwind, D. H. (2017). ASD restricted and repetitive behaviors associated at 17q21.33: Genes prioritized by expression in fetal brains. Molecular Psychiatry, 00(September 2016), 1–8. https://doi.org/10.1038/mp.2017.114.
Caravaggio, F., Nakajima, S., Plitman, E., Gerretsen, P., Chung, J. K., Iwata, Y., & Graff-Guerrero, A. (2016). The effect of striatal dopamine depletion on striatal and cortical glutamate: A mini-review. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 65, 49–53. https://doi.org/10.1016/j.pnpbp.2015.08.013.
Chakrabotri, B., Verma, D., Karmakar, A., Jaiswal, P., Sanyal, A., Paul, D., et al. (2016). Genetic variants of MAOB affect serotonin level and specific behavioral attributes to increase autism spectrum disorder (ASD) susceptibility in males. Progress in Neuropsychopharmacology and Biological Psychiatry, 71, 123–136. https://doi.org/10.1016/j.pnpbp.2016.07.001.
Chao, H., Chen, H., Samaco, R. C., Xue, M., Yoo, J., Neul, J. L., et al. (2011). GABAergic dysfunction mediates autism-like stereotypies and Rett syndrome phenotypes. Nature, 468(7321), 263–269. https://doi.org/10.1038/nature09582.GABAergic.
Coghlan, S., Horder, J., Inkster, B., Mendez, M. A., & Declan, G. (2012). GABA system dysfunction in autism and related disorders: From synapse to symptoms. Neuroscience & Biobehavioral Reviews, 36(9), 2044–2055. https://doi.org/10.1016/j.neubiorev.2012.07.005.GABA.
Collins, A. L., Ma, D., Whitehead, P. L., Martin, E. R., Wright, H. H., Abramson, R. K., et al. (2006). Investigation of autism and GABA receptor subunit genes in multiple ethnic groups. Neurogenetics, 7(3), 167–174. https://doi.org/10.1007/s10048-006-0045-1.
Cook, E. H., & Leventhal, B. L. (1996). The serotonin system in autism. Current Opinion in Pediatrics, 8(4), 348–354. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9053096.
Dykens, E. M., Cassidy, S. B., & King, B. H. (1999). Maladaptive behavior differences in Prader-Willi syndrome due to parental deletion versus maternal uniparental disomy. American Journal on Mental Retardation, 104(1), 67–77.
Dykens, E., & Shah, B. (2003). Psychiatric disorders in Prader-Willi syndrome epidemiology and management. CNS Drugs, 17(3), 167–178.
Ernst, A. M., & Smelik, P. G. (1966). Site of action of dopamine and apomorphine on compulsive gnawing behaviour in rats. Experientia, 22(12), 837–838. https://doi.org/10.1007/BF01897450.
Estes, A., Shaw, D. W. W., Sparks, B. F., Friedman, S., Giedd, J. N., Dawson, G., et al. (2012). Basal ganglia morphometry and repetitive behavior in young children with autism spectrum disorder. Autism Research, 4(3), 212–220. https://doi.org/10.1002/aur.193.Basal.
Evans, D. W. (2017). Relationship between repetitive behaviour and fear across normative development, autism spectrum disorder, and down syndrome. Autism Research, 10(3), 502–507. https://doi.org/10.1002/aur.1674.
Evans, D. W., Leckmn, J. F., Carter, A., Raznick, J. S., Henshaw, D., King, R. A., & Pauls, D. (1997). Rituals, habit and perfectionism: The prevalence and development of compulsive-like behavior in normal young children. Child Development, 68(1), 58–68.
Fatemi, S. H., Reutiman, T. T., Folsom, T. D., & Thoras, P. D. (2009). GABA A receptor downregulation in brains of subjects with autism. Journal of Autism and Developmental Disorders, 39, 223–230. https://doi.org/10.1007/s10803-008-0646-7.
Francis, S. M., Kim, S., Kistner-griffin, E., Guter, S., Cook, E. H., Jacob, S., & Ebstein, R. P. (2016). ASD and genetic associations with receptors for oxytocin and vasopressin—AVPR1A, AVPR1B, and OXTR. Frontiers in Neuroscience, 10(November), 1–10. https://doi.org/10.3389/fnins.2016.00516.
Francis, S. M., Kistner-griffin, E., Yan, Z., Guter, S., Cook, E. H., & Jacob, S. (2016). Variants in adjacent oxytocin/vasopressin gene region and associations with ASD diagnosis and other autism related endophenotypes. Frontiers in Neuroscience, 10(May), 195. https://doi.org/10.3389/fnins.2016.00195.
Frith, U., & Happe, F. (1994). Autism: beyond “ theory of mind”. Cognition, 50, 115–132.
Gaffney, G. R., Kuperman, S., Tsai, L. Y., & Minchin, S. (1989). Forebrain structure in infantile autism. Journal of the American Academy of Child and Adolescent Psychiatry, 28(4), 534–537. https://doi.org/10.1097/00004583-198907000-00011.
Geschwind, D. H. (2011). Genetics of autism spectrum disorders. Trends in Cognitive Sciences, 15(9), 409–416. https://doi.org/10.1016/j.tics.2011.07.003.
Goldman, S., O’Briend, L. M., Filipekf, P. A., Rapina, I., & Herbertg, M. R. (2013). Motor stereotypies and volumetric brain alterations in children with Autistic Disorder. Research in Autism Spectrum Disorders, 7(1), 82–92. https://doi.org/10.1016/j.rasd.2012.07.005.Motor.
Graybiel, A. M., & Rauch, S. L. (2000). Toward a neurobiology of obsessive-compulsive disorder. Neuron, 28(4), 343–347.
Hall, S., Thorns, T., & Oliver, C. (2003). Structural and environmental characteristics of stereotyped behaviors. American Journal of Mental Retardation, 108(6), 391–402.
Hamilton, P. J., Campbell, N. G., Sharma, S., Erreger, K., Herborg Hansen, F., Saunders, C., et al. (2014). De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder Peter. Molecular Psychiatry, 18(12), 1315–1323. https://doi.org/10.1038/mp.2013.102.De.
Harris, A. D., Singer, H. S., Horska, A., Kline, T., Ryan, M., Edden, R. A., & Mahone, E. M. (2016). GABA and glutamate in children with primary complex motor stereotypies: A1H MRS study at 7T. American Journal of Neuroradiology, 37(3), 552–557. https://doi.org/10.3174/ajnr.A4547.GABA.
Hollander, E., Anagnostou, E., Chaplin, W., Esposito, K., Haznedar, M. M., Licalzi, E., … Buchsbaum, M. (2005). Striatal volume on magnetic resonance imaging and repetitive behaviors in autism. Biological Psychiatry, 58(3), 226–232. https://doi.org/10.1016/j.biopsych.2005.03.040
Hutt, B. Y. C., & Hutt, S. J. (1965). Effects of environmental complexity on stereoptyped behaviours of children. Animal Behaviour, 13(1), 1–4.
Hutt, C., Hutt, S. J., Lee, D., & Ounsted, C. (1964). Arousal and childhood autism. Nature, 204(4961), 908–909.
Jamain, S., Betancur, C., Quach, H., Philippe, A., Fellous, M., Giros, B., et al. (2002). Linkage and association of the glutamate receptor 6 gene with autism. Molecular Psychiatry, 7(3), 302–310. https://doi.org/10.1038/sj/mp/4000979.
Jiujias, M., Kelley, E., Hall, L., & Kelley, E. (2017). Restricted, repetitive behaviors in autism spectrum disorder and obsessive – compulsive disorder: a comparative review. Child Psychiatry and Human Development, 48(6), 944–959. https://doi.org/10.1007/s10578-017-0717-0.
Joyce, C., Honey, E., Leekam, S. R., Barrett, S. L., Rodgers, J., & Joyce, C. (2017). Anxiety, intolerance of uncertainty and restricted and repetitive behaviour: Insights directly from young people with ASD. Journal of Autism and Developmental Disorders, 47(12), 3789–3802. https://doi.org/10.1007/s10803-017-3027-2.
Just, M. A., Cherkassky, V. L., Keller, T. A., & Minshew, N. J. (2004). Cortical activation and synchronization during sentence comprehension in high-functioning autism: Evidence of underconnectivity. Brain, 127, 1811–1821. https://doi.org/10.1093/brain/awh199.
Kennes, F. O., Odberg, Y. B., & de Rycke, P. H. (1988). Changes in naxolone and heloperidol effects during the development of captivity-induced jumping stereotypy in bank voles. European Journal of Pharmacology, 153(1), 19–24.
Kim, S. H., & Lord, C. (2010). Restricted and repetitive behaviors in toddlers and preschoolers with autism spectrum disorders based on the Autism Diagnostic Observation Schedule (ADOS). Autism Research, 3(4), 162–173. https://doi.org/10.1002/aur.142.
Lainhart, J. E., Piven, J., Wzorek, M., Ph, D., Landa, R., Ph, D., et al. (1997). Macrocephaly in children and adults with autism. Journal of the American Academy of Child and Adolescent Psychiatry, 36(2), 282–290. https://doi.org/10.1097/00004583-199702000-00019.
Langen, M., Durston, S., Kas, M. J. H., Van Engeland, H., & Staal, W. G. (2011). The neurobiology of repetitive behavior … and men. Neuroscience and Biobehavioral Reviews, 35(1), 356–365. https://doi.org/10.1016/j.neubiorev.2010.02.005.
Langen, M., Durston, S., Staal, W. G., Palmen, S. J. M. C., & Van Engeland, H. (2007). Caudate nucleus is enlarged in high-functioning medication-naive subjects with autism. Biological Psychiatry, 62(3), 262–266. https://doi.org/10.1016/j.biopsych.2006.09.040.
Lewis, M., & Kim, S.-J. (2009a). The pathophysiology of restricted repetitive behavior. Journal of Neurodevelopmental Disorders, 1(2), 114–132. https://doi.org/10.1007/s11689-009-9019-6.
Lewis, M., & Kim, S. (2009b). The pathophysiology of restricted repetitive behavior. Journal of Neurodevelopmental Disorders, 1(June), 114–132. https://doi.org/10.1007/s11689-009-9019-6.
Lewis, M. H., Bodfish, J. W., Powell, S. B., Wiest, K., Darling, M., & Golden, R. N. (1996). Plasma HVA in adults with mental retardation and stereotyped behavior: biochemical evidence for a dopamine deficiency model. American Journal of Mental Retardation: AJMR, 100(4), 413–418. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/8718995.
Lewis, M. H., & Baumeister, A. A. (1982). Stereotyped mannerisms in mentally retarded persons: Animal models and theoretical analyses. International Review of Research in Mental Retardation, 11, 123–161.
Lewis, M. H., & Bodfish, J. W. (1998). Repetitive behavior disorders in autism. Mental Retardation and Developmental Disabilities Research Reviews, 4, 80–89.
Li, Y.-C., Wang, M.-J., & Gao, W.-J. (2012). Hyperdopaminergic modulation of inhibitory transmission is dependent on GSK-3β signaling-mediated trafficking of GABAA receptors. Journal of Neurochemistry, 122(2), 308–320. https://doi.org/10.1111/j.1471-4159.2012.07790.x.
Lord, C., Risi, S., Lambrecht, L., Cook, E. H. J., Leventhal, B. L., DiLavore, P. C., et al. (2000). The Autism Diagnostic Schedule – Generic: A standard measures of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223. https://doi.org/10.1023/A:1005592401947.
Lord, C., Rutter, M., & LeCouteur, A. (1994). Autism diagnostic interview: A revised version of a diagnostic interview for caregivers of individual s with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24(5), 659–685. Retrieved from http://search.ebscohost.com/login.aspx?direct=true&db=epref&AN=JADD.BD.FEI.LORD.ADIRVD&site=ehost-live.
Lovaas, I., Newsome, C., & Hickman, C. (1987). Self-stimulatory behavior and perceptual reinforcement. Journal of Applied Behavior Analysis, 20(1), 45–68.
Ma, D. Q., Whitehead, P. L., Menold, M. M., Martin, E. R., Mei, H., Ritchie, M. D., et al. (2005). Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. The American Journal of Human Genetics, 77(3), 377–388.
Monk, C. S., Peltier, S. J., Wiggins, J. L., Weng, S. J., Carrasco, M., Risi, S., & Lord, C. (2009). Abnormalities of intrinsic functional connectivity in autism spectrum disorders. NeuroImage, 47(2), 764–772. https://doi.org/10.1016/j.neuroimage.2009.04.069.
Moss, J., Oliver, C., Arron, K., Burbidge, C., & Berg, K. (2009). The prevalence and phenomenology of repetitive behavior in genetic syndromes. Journal of Autism and Developmental Disorders, 39(4), 572–588. https://doi.org/10.1007/s10803-008-0655-6.
Mostert-Kerckhoffs, M. A. L., Staal, W. G., & Houben, R. H. (2015). Stop and change: Inhibition and flexibility skills are related to repetitive behavior in children and young adults with autism spectrum disorders. Journal of Autism and Developmental Disorders, 45(10), 3148–3158. https://doi.org/10.1007/s10803-015-2473-y.
Muhle, R. A., Reed, H. E., Stratigos, K. A., & Veenstra-vanderweele, J. (2018). The emerging clinical neuroscience of autism spectrum disorder A review. JAMA Psychiatry, 75(5), 514–523. https://doi.org/10.1001/jamapsychiatry.2017.4685.
Newschaffer, C. J., Denckla, Æ. M. B., Landa, R., & Mostofsky, Æ. S. H. (2006). Motor signs distinguish children with high functioning autism and Asperger’s syndrome from controls. Journal of Autism Developmentall Disorder, 36(1), 613–621. https://doi.org/10.1007/s10803-006-0109-y.
Nguyen, M., Roth, A., Kyzar, E. J., Poudel, M. K., Wong, K., Stewart, A. M., & Kalueff, A. V. (2014). Decoding the contribution of dopaminergic genes and pathways to autism spectrum disorder (ASD). Neurochemistry International, 66(1), 15–26. https://doi.org/10.1016/j.neuint.2014.01.002.
Nomi, J. S., & Uddin, L. Q. (2015). Developmental changes in large-scale network connectivity in autism. NeuroImage: Clinical, 7, 732–741. https://doi.org/10.1016/j.nicl.2015.02.024.
Ramaswami, G., & Geschwind, D. H. (2018). Genetics of autism spectrum disorder. In Handbook of clinical neurology (Vol. 147, 1st ed.). https://doi.org/10.1016/B978-0-444-63233-3.00021-X.
Ranson, B. J., Piven, J., Lonnie, L., Vest, C., Mohamed, S., Bailey, J., et al. (1999). An MRI study of the basal ganglia in autism. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 23(Apa 1995), 613–624.
Richler, J., Huerta, M., Bishop, S. L., & Lord, C. (2010). Developmental trajectories of restricted and repetitive behaviors and interests in children with autism spectrum disorders. Development and Psychopathology, 22(1), 55–69. https://doi.org/10.1017/S0954579409990265.
Rojas, D. C., Peterson, E., Winterrowd, E., Reite, M. L., Rogers, S. J., & Tregellas, J. R. (2006). Regional gray matter volumetric changes in autism associated with social and repetitive behavior symptoms. BMC Psychiatry, 6(1), 56. https://doi.org/10.1186/1471-244X-6-56.
Ronald, A., Happ, F., Bolton, P., Sych, F. R. C. P., Butcher, L. E. E. M., Price, T. S., & Wheelwright, S. (2006). Genetic heterogeneity between the three components of the autism spectrum: A twin study. Journal of the American Academy of Child & Adolescent Psychiatry, 45(6), 691–699. https://doi.org/10.1097/01.chi.0000215325.13058.9d.
Ronald, A., Happé, F., & Plomin, R. (2005). The genetic relationship between individual differences in social and nonsocial behaviours characteristic of autism. Developmental Science, 8(5), 444–458. https://doi.org/10.1111/j.1467-7687.2005.00433.x.
Rosenthal, M., Wallace, G. L., Lawson, R., Wills, M. C., Dixon, E., Yerys, B. E., & Kenworthy, L. (2013). Impairments in real-world executive function increase from childhood to adolescence in autism spectrum disorders. Neuropsychology, 27(1), 13–18. https://doi.org/10.1037/a0031299.
Schain, R. J., & Freedman, D. X. (1961). Studies on 5-bydroxyindole metabolism in autistic and other mentally retarded children. The Journal of Pediatrics, 58(3), 315–320.
Scheel-Krüger, J., Arnt, J., Braestrup, C., Christensen, A. V., Cools, A. R., & Magelund, G. (1978). GABA-dopamine interaction in substantia nigra and nucleus accumbens -relevance to behavioral stimulation and stereotyped behavior. Advances in Biochemical Psychopharmacology, 19, 343–346. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/567933.
Scheel-Kruger, J., Arnt, J., Magelund, G., Olianas, M., Przewlocka, B., & Christensen, A. V. (1980). Behavioural functions of GABA in basal ganglia and limbic system. Brain Research Bulletin, 5(2), 261–267.
Schmitt, L. M., White, S. P., Cook, E. H., Sweeney, J. A., & Mosconi, M. W. (2017). Cognitive mechanisms of inhibitory control deficits in autism spectrum disorder. Journal of Child Psychology and Psychiatry, 59(5), 586–595. https://doi.org/10.1111/jcpp.12837.
Shih, P., Shen, M., Öttl, B., Keehn, B., Gaffrey, M. S., & Müller, R. A. (2010). Atypical network connectivity for imitation in autism spectrum disorder. Neuropsychologia, 48(10), 2931–2939. https://doi.org/10.1016/j.neuropsychologia.2010.05.035.
Silverman, J. L., Pride, M. C., Hayes, J. E., Puhger, K. R., Butler-struben, H. M., Baker, S., & Crawley, J. N. (2015). GABA B receptor agonist R-baclofen reverses social deficits and reduces repetitive behavior in two mouse models of autism. Neuropsychopharmacology, 40(9), 2228–2239. https://doi.org/10.1038/npp.2015.66.
Sloman, K. N., LaRue, R. H., Weiss, M. J., & Hansford, A. S. (2013). Best practices in the assessment and treatment of stereotypical behaviour in individuals with autism. In J. M. Zachor & A. Ditza (Eds.), Understanding autism (pp. 29–37). Nova Science Publishers.
Smith, R. M., Banks, W., Hansen, E., Sadee, W., & Herman, G. E. (2014). Family-based clinical associations and functional characterization of the serotonin 2A receptor gene (HTR2A) in autism spectrum disorder. Autism Research, 7(4), 459–467. https://doi.org/10.1002/aur.1383.
Smith, Y., Bevan, M. D., Shink, E., & Bolam, J. P. (1998). Microcircuitry of the direct and indirect pathways of the basal ganglia. Neuroscience, 86(2), 353–387.
Staal, W. G., De Krom, M., & De Jonge, M. V. (2012). Brief report: The dopamine-3-receptor gene (DRD3) is associated with specific repetitive behavior in autism spectrum disorder (ASD). Journal of Autism and Developmental Disorders, 42(5), 885–888. https://doi.org/10.1007/s10803-011-1312-z.
State, M. W., & Dykens, E. M. (2000). Genetics of childhood disorders: XV. Prader-Willi syndrome: Genes, brain, and behavior. Developmental Neurobiology, 39(6), 797–800. https://doi.org/10.1097/00004583-200006000-00021.
Stocco, A., Lebiere, C., & Anderson, J. R. (2011). Conditional routing of information to the cortex: A model of the basal Ganglia’s role in cognitive coordination. Psychologic Review, 117(2), 541–574. https://doi.org/10.1037/a0019077.Conditional.
Stratis, E. A., & Lecavalier, L. (2013). Restricted and repetitive behaviors and psychiatric symptoms in youth with autism spectrum disorders. Research in Autism Spectrum Disorders, 7(6), 757–766. https://doi.org/10.1016/j.rasd.2013.02.017.
Street, D. (1994). The psychology of perservative and stereotyped behaviour. Progress in Neurobiology, 44(2), 221–231.
Sullivan, J., Rodgers, J., Lidstone, J., Uljarevic, M., Mcconachie, H., Freeston, M., et al. (2014). Research in Autism Spectrum Disorders Relations among restricted and repetitive behaviors, anxiety and sensory features in children with autism spectrum disorders. Research in Autism Spectrum Disorders, 8(2), 82–92. https://doi.org/10.1016/j.rasd.2013.10.001.
Supekar, K., & Menon, V. (2015). Sex differences in structural organization of motor systems and their dissociable links with repetitive/restricted behaviors in children with autism. Molecular Autism, 6(50). https://doi.org/10.1186/s13229-015-0042-z.
Sutcliffe, J. S., Delahanty, R. J., Prasad, H. C., Mccauley, J. L., Han, Q., Jiang, L., et al. (2005). Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors. American Journal of Human Genetics, 77, 265–279.
Tao, Y., Gao, H., Ackerman, B., Guo, W., Saffen, D., & Shugart, Y. Y. (2016). Evidence for contribution of common genetic variants within chromosome 8p21.2-8p21.1 to restricted and repetitive behaviors in autism spectrum disorders. BMC Genomics, 17(163), 1–15. https://doi.org/10.1186/s12864-016-2475-y.
Turner, M. (1999). Repetitive behaviour in autism: A review of psychological research. Journal of Child Psychology and Psychiatry, 40(6), 839–849.
Uljarevi, M., Evans, D. W., Alvares, G. A., & Whitehouse, A. J. O. (2016). Short report: Relationship between restricted and repetitive behaviours in children with autism spectrum disorder and their parents. Molecular Autism, 7(29), 1–5. https://doi.org/10.1186/s13229-016-0091-y.
Veltman, M. W. M., Craig, E. E., & Bolton, P. F. (2005). Autism spectrum disorders in Prader – Willi and Angelman syndromes: A systematic review. Psychiatric Genetics, 15(4), 243–254.
Voelbel, G. T., Bates, M. E., Buckman, J. F., Pandina, G., & Hendren, R. L. (2006). Caudate nucleus volume and cognitive performance: Are they related in childhood psychopathology? Biological Psychiatry, 60(9), 942–950. https://doi.org/10.1016/j.biopsych.2006.03.071.
Williams, K., Brignell, A., Randall, M., Silove, N., & Hazell, P. (2013). Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD) (Review). Cochrane Database of Systematic Reviews, ((8), CD004677. https://doi.org/10.1002/14651858.CD004677.pub3. https://www.cochranelibrary.com/.
Yang, P., & Chang, C.-L. (2014). Glutamate-mediated signaling and autism spectrum disorders: Emerging treatment targets. Current Pharmaceutical Design, 20(32), 5186–5193. https://doi.org/10.2174/1381612819666140110120725.
Yonan, A. L., Alarco, M., Cheng, R., Magnusson, P. K. E., Spence, S. J., Palmer, A. A., et al. (2003). A genomewide screen of 345 families for autism-susceptibility loci. American Journal of Human Genetics, 73(4), 886–897.
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Poleg, S., Zachor, D.A. (2021). Neurological Mechanisms Underlying Repetitive and Restricted Behaviors in Autism Spectrum Disorders. In: Gal, E., Yirmiya, N. (eds) Repetitive and Restricted Behaviors and Interests in Autism Spectrum Disorders. Autism and Child Psychopathology Series. Springer, Cham. https://doi.org/10.1007/978-3-030-66445-9_3
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DOI: https://doi.org/10.1007/978-3-030-66445-9_3
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