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The αβ/γδ Lineage Decision

An Evaluation of the “T-Cell Receptor Determinant,” “Progenitor Precommitment,” or “Codeterminant” Models

  • Chapter
Molecular Biology of B-Cell and T-Cell Development

Part of the book series: Contemporary Immunology ((CONTIM))

Abstract

An accident of molecular biology in 1984 (1,2) prefaced a roundly unanticipated fact, that vertebrates make two sets of qualitatively distinct T-cells: αβ T-cells and γδ T-cells (3). There are many differences between these cell types, most notably in the antigen receptors that define them. Whereas αβ T-cell receptors (TCRs) mostly recognize complexes of antigenic peptide and major histocompatibility complex (MHC) molecules, γδTCRs recognize a spectrum of cell-associated antigens which seems as diverse as the antigen specificity of immunoglobulins (4). Moreover, in mice lacking Syk kinase, sets of γδ cells fail to develop, like B-cells, whereas αβ T-cell development progresses apparently normally (5, 6). These observations suggest that γδ cells and αβ T-cells are extremely different, and likely to arise from progenitor cells that diverge early during lymphopoiesis. Conversely, there is an obligatory association of TCRγδ and TCRαβ with the polypeptide complex, CD3, that has been used as the defining feature of T-cells. Additionally, many (possibly most) γδ cells arise from the thymus (7, 8). By these criteria, γδ cells and αβ T-cells may be sisters, arising from a late lineage decision of a common intrathymic precursor.

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Authors
  1. Eric S. Hoffman
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  2. Lorena Passoni
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  3. Erastus C. Dudley
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  4. Michael Girardi
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  5. Adrian Hayday
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Editor information

Editors and Affiliations

  1. University of Pennsylvania, Philadelphia, PA, USA

    John G. Monroe

  2. California Institute of Technology, Pasadena, CA, USA

    Ellen V. Rothenberg

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© 1998 Springer Science+Business Media New York

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Hoffman, E.S., Passoni, L., Dudley, E.C., Girardi, M., Hayday, A. (1998). The αβ/γδ Lineage Decision. In: Monroe, J.G., Rothenberg, E.V. (eds) Molecular Biology of B-Cell and T-Cell Development. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2778-4_19

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  • DOI: https://doi.org/10.1007/978-1-4757-2778-4_19

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-065-6

  • Online ISBN: 978-1-4757-2778-4

  • eBook Packages: Springer Book Archive

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