Ulrich Betz

„Nach dem Spiel ist vor dem Spiel“ (Sepp Herberger) This is not only true for soccer, but also for scientific meetings. After #Bio2024 in San Diego and #EACR in Rotterdam, we are at the Meeting of the Federation of European Neuroscience Societies #FENS2024 in Vienna. The ariadne.ai booth is ready and Tosin Oyewale and I will be there from tomorrow onwards, helping you with all questions regarding image analysis and spatial biology in neuroscience. #neurology #neuroscience #imageanalysis #imageprocessing #spatialtranscriptomics #spatialproteomics #spatialbiology

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📺 You missed the #BIOPOLYMERCongress2024 but are keenly interested in the lectures? Then check out our #YouTube channel now. Here you will find all the presentations from 2024 as recordings: https://lnkd.in/e3ngPpz2 #biopolymer #biopolymercongress #thinkgreen 💚

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In the current issue of BIOspektrum you will find an exciting article by Prof Dr Bernhard Hube, PI in our #ClusterOfExcellence! Hube talks about his research on human pathogenic fungi, with a particular focus on Candida species, as well as the progress made in understanding fungal infections and the development of new approaches to tackle these challenges. 📰 Read the interview here: https://lnkd.in/ezaUF697 🗞️... and the corresponding BIOspektrum article: https://lnkd.in/edgKHUts

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Prodrug resources: 1) The expanding role of prodrugs in contemporary drug design and development (2018) https://lnkd.in/dQbvkWqS by Jarkko Rautio, Nicholas A. Meanwell, Li Di and Michael Hageman. 2) The landscape of small-molecule prodrugs (2024) https://lnkd.in/djs_Ya3f by Zachary Fralish, Ashley Chen, Shaharyar Khan, Pei Zhou & Daniel Reker. Open access: https://rdcu.be/dDoA6 Further readings: 1) Prodrugs—from Serendipity to Rational Design (2011) https://lnkd.in/dC2Ngyu3 2) Prodrugs: design and clinical applications (2008) https://lnkd.in/dD-sAudT

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Affinity Selection Mass Spectrometry (ASMS) is a powerful technique in drug discovery, efficiently identifying small molecules for protein-protein interactions (PPIs) and other challenging targets, such as membrane proteins and RNA. Drug discovery experts acknowledged at the recent DDC conference their utilization of services from WuXi AppTec, underlining the practical effectiveness of ASMS in discovering potential hits on those challenging targets. WuXi AppTec’s ASMS platform has demonstrated high proficiency in this field, as shown by our case studies involving successful screening of membrane proteins and identification of molecular glues. Click 👇 to explore our ASMS platform and access the mini posters from our showcases. #ASMS #MembraneProtein #MolecularGlue #PPI #TPD #CIP #RNA #DDC #DrugDiscovery https://lnkd.in/g44Nh6E2

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A team from ZHAW Zurich has showcased the transferability of CHO-cell-based mAb production processes from geometrically dissimilar stirred bioreactors for fed-batch and perfusion processes, the team has opened up new possibilities for cost savings and increased yields. Their study found that the high volumetric productivity in the perfusion processes can lead to cost savings, smaller bioreactor sizes, and maintained manufacturing capacity in production plants. Alternatively, yields could be increased by a factor of 2.8 to 3.2 while still using the same bioreactor size. We look forward to seeing how it will impact the future of antibody production. #biotech #antibodyproduction #research https://lnkd.in/eA9992FV

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Interested in how early #formulationdevelopment and product characterization influence the drug development process? 🧪 Discover more in our on-demand webinar by Nadja Prang, MBA, Chief Scientific Officer at TECObiosciences GmbH: 🔗 𝗥𝗲𝗴𝗶𝘀𝘁𝗲𝗿 𝗵𝗲𝗿𝗲: https://lnkd.in/da7Np_E4 Dr. Nadja Prang, an expert in Pharmaceutical Product Development in the EU and US, advises on #CMC strategies, preclinical and clinical safety, and QC/QA for Biotech Product Development 🔑 ​𝐊𝐄𝐘 𝐓𝐀𝐊𝐄𝐀𝐖𝐀𝐘𝐒: Significant changes after light stress and de-amidation stress at 40°C Increased visible and sub-visible particles with low pH stress Minor changes with thermal, freeze-thaw, oxidative, and mechanical stress HSA-fusion protein is most affected by light and high pH stress Boost your #biotech product development knowledge today! 💡🌟 #PharmaceuticalDevelopment #CMC #DrugDevelopment #FormulationDevelopment #ProductCharacterization #BiotechWebinar #PharmaExpert #CMCStrategies #QualityControl #QualityAssurance #Biopharma #BiotechInnovation #HealthcareScience

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Using 'representation vectors' instead of prompt engineering to modulate #LLM responses enables tuneable behavior: https://lnkd.in/eUwSUvtg

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Why Seneca's philosophical insights may not resonate for everyone, especially when considering life's practical challenges and the limitations of our experiences. Time to rethink aging and our approach to death in light of modern possibilities. https://lnkd.in/gEregTen #bioviva #genetherapy #lizparrish #biohacking #biohacker #CRISPR #biohack #fitness #healthylifestyle #motivation #keto #nootropics #nutrition #biohackers #biohackingsecrets #longevity #meditation #brainhealth #mindfulness #healthy #functionalmedicine #antiaging #heart disease #telomeres #klotho #healthnews #dementia #alzheimers

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Scale up your industry knowledge at the European Biomanufacturing Summit on 10-11 September 2024 in Berlin, Germany. Immerse yourself with over 120 biomanufacturing experts in lively discussions on biomanufacturing #cellandgene #biologics and #biosimilars, along with many other core discussions in the industry. Stay at the forefront of industry trends and connect with top innovators in the #biomanufacturing industry https://hubs.ly/Q02C1N8k0 #BioEU24 #GenerisBIOEU

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Abyntek Biopharma, mentioned in Nature Portfolio!   Access the latest research summary from our blog, published in the high-impact journal Nature, where #bioreagents from the Abyntek Research Reagents brand, such as our #ELISA kits, have played a significant role in the detection and measurement of #catecholamines.   Under the title “Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis”, various research centers involved detail the most significant finding as the inhibition of the Mat1a gene, which reverses and prevents obesity, insulin resistance, and associated hepatosteatosis by reducing serum lipids. It is demonstrated that Mat1a deficiency has beneficial effects on metabolism and brown adipose tissue (BAT) function, as well as on lipid synthesis in the liver.   👉 Continue Reading in our blog: https://lnkd.in/dZ6T_md5   🔬 Discover Abyntek Research Reagents, used brand in the reagent panel for this research: https://lnkd.in/db2NPwb3   #Biotech https://lnkd.in/dZ6T_md5

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Asking for a friend 😎 "Dear ChatGPT, what is Philipp famous for?" Philipp Baaske, co-founder and Co-CEO of NanoTemper Technologies, is renowned for his entrepreneurial spirit and significant contributions to the biotechnology and life sciences industries. He is particularly famous for: 1. Innovative Technology Development: Philipp Baaske has played a crucial role in the development and commercialization of cutting-edge biophysical instruments that have transformed approaches in drug discovery and molecular research. NanoTemper Technologies is known for its precision instruments like the Monolith and Prometheus, which are used globally in academic and pharmaceutical research to study molecular interactions. 2. Leadership in Biotechnology: Under his leadership, NanoTemper Technologies has grown from a university spin-off into a profitable and internationally recognized company. His vision has helped bridge the gap between academic research findings and practical, market-ready biotechnological applications. 3. Contributions to Scientific Community: Philipp is also recognized for his active role in fostering collaborations and knowledge exchange within the scientific community. He frequently engages in discussions and events that promote innovation and application in biotechnology and pharmaceutical sciences. 4. Entrepreneurial Success: His journey from starting NanoTemper in a university setting to leading a successful global company serves as an inspiration to many budding entrepreneurs in the biotech field, showcasing the potential of turning scientific expertise into successful business ventures. Philipp Baaske's impact extends beyond the technical innovations of his company to include his influence on industry standards and practices, making him a notable figure in the international biotech community. Funny and interesting to read what ChatGPT thinks about me. What would you ask for a friend? Life is better with humor 😂 #biotechnology #entrepreneurship #startup ————————— I am Philipp - founder, CEO & business angel. My bootstrapped company NanoTemper is a global leader for biophysical tools for biotech. Like my content? Click my name + follow + 🔔

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Another important step.

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The International Society for Pharmaceutical Engineering (ISPE) sought to accelerate guideline development for #allogeneic #celltherapy. This discussion with United Therapeutics' Erich Bozenhardt, PE digs into some of the bigger themes in its recent guide. #celltherapymanufacturing #cellandgenetherapy #CGT https://lnkd.in/eqfDXDg3

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The #downstreamprocessing of #lentiviralvectors is fraught with challenges that must be addressed if the requisite high levels of recovery, quality, and consistency are to be achieved. The #infographic below distills the advice of experts spanning the pharma/biotech, academic, and tools innovation sectors to smooth the pathway to #lentiviruspurification success. https://buff.ly/3UcddH8 Recently published content covering innovative research in this space also includes an #ebook, where you will find: • A unique curated collection of articles, videos, and posters dedicated to the #lentiviral processing field • Valuable insights into overriding trends in the evolution and application of #lentiviralvectors • Answers to specific questions regarding the optimal approach to manufacturing and in particular, lentiviral vector purification https://buff.ly/3sNdaI6 These are just a few of the resources available on our Purification Hub. The #hub explores the key role that #viralvectors and #mRNA play in cell and #genetherapy, the current challenges facing the field, and potential solutions for successful manufacture. Once you’ve read your first piece of content, all the rest is available to you open access. Visit the hub below: https://buff.ly/3T12nDj

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Berlin Center for Gene and Cell Therapies Kicked-off in Berlin Bayer and Charité - Universitätsmedizin Berlin recently unveiled plans to establish the Berlin Center for Gene and Cell Therapies, a translational center for gene and cell therapies. The project is supported by Germany’s Federal Government and the State of Berlin, aiming to bring these groundbreaking technologies to patients more quickly while creating a leading #biotech ecosystem for innovative #therapies in Berlin. Cell and gene therapies (#CGTs) have enormous potential. By targeting diseases at the genetic and cellular level, CGTs could offer options to people for whom conventional therapies have failed or where no effective treatment is currently available. Charité and Bayer will establish the center on the Bayer campus at Berlin Nordhafen. The center will support #startups bringing their innovative approaches in the area of cell therapies and gene therapies into clinical development. The center will include a fully equipped laboratory space and a production area certified according to the standards of good manufacturing practice (#GMP). Participating early-stage companies will receive advice on regulatory requirements, clinical trials, patent rights, and business development. Bayer and Charité will establish a joint public-private, non-profit company with limited liability. #Charité will own 67 percent of this company, with #Bayer owning the remaining 33 percent. Read more on #CMI online: https://lnkd.in/eS6pG8uy

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Comparing Separations Systems for mAb Manufacturing During monoclonal antibody production, variability during cell culturing can compromise bioseparation efficiency and therapeutic efficacy. For this evaluation, Wil Jones, PhD candidate, and Dimitrios I. Gerogiorgis, PhD, deputy head, Research Institute for Materials and Processes, The University of Edinburgh, combined a pH-dependent steric mass action model for polishing chromatography with a semi-empirical model.

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👉 Please see a very good report in #Blick about our head of research Ingrid Rauter and our objectives in the #cancer #research of an autologous #tumorvaccine and why our path is promising!

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