Dr. Tim Wiegels

Hamburg, Hamburg, Deutschland Kontaktinformationen
4766 Follower:innen 500+ Kontakte

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    Unternehmensberatung, Veränderungsmanagement, IT-Beratung, Erstellen von Datenberichten, Business Analytics, Öffentliches Reden und Führungskräfteentwicklung

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Erfahrener Leader und Experte für “all things Data” mit akademischem Hintergrund und…

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Berufserfahrung und Ausbildung

  • Tim Wiegels Data Solutions

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Ehrenamt

  • Hamburger Goldkehlchen e.v. Grafik

    Singer (Bass)

    Hamburger Goldkehlchen e.v.

    –Heute 7 Jahre 8 Monate

    Arts and Culture

  • EMBL Grafik

    Doktorandenvertreter / PhD Student Representative

    EMBL

    – 3 Jahre

  • University of Hamburg Grafik

    Studentenvertreter / Student Representative Bioinformatik

    University of Hamburg

    – 1 Jahr 11 Monate

    Education

Veröffentlichungen

  • RNA secondary structure diagrams for very large molecules: RNAfdl.

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  • Fast alignment and comparison of RNA structures.

    Bioinformatics

    To recognize remote relationships between RNA molecules, one must be able to align structures without regard to sequence similarity. We have implemented a method, which is swift [O(n(2))], sensitive and tolerant of large gaps and insertions. Molecules are broken into overlapping fragments, which are characterized by their memberships in a probabilistic classification based on local geometry and H-bonding descriptors. This leads to a probabilistic similarity measure that is used in a…

    To recognize remote relationships between RNA molecules, one must be able to align structures without regard to sequence similarity. We have implemented a method, which is swift [O(n(2))], sensitive and tolerant of large gaps and insertions. Molecules are broken into overlapping fragments, which are characterized by their memberships in a probabilistic classification based on local geometry and H-bonding descriptors. This leads to a probabilistic similarity measure that is used in a conventional dynamic programming method.

    Examples are given of database searching, the detection of structural similarities, which would not be found using sequence based methods, and comparisons with a previously published approach.

    Andere Autor:innen
    • Andrew Torda
    • Stefan Bienert
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  • Visual Automated Macromolecular Model Building

    Acta. Crystallogr. D

    Automated model-building software aims at the objective interpretation of crystallographic diffraction data by means of the construction or completion of macromolecular models. Automated methods have rapidly gained in popularity as they are easy to use and generate reproducible and consistent results. However, the process of model building has become increasingly hidden and the user is often left to decide on how to proceed further with little feedback on what has preceded the output of the…

    Automated model-building software aims at the objective interpretation of crystallographic diffraction data by means of the construction or completion of macromolecular models. Automated methods have rapidly gained in popularity as they are easy to use and generate reproducible and consistent results. However, the process of model building has become increasingly hidden and the user is often left to decide on how to proceed further with little feedback on what has preceded the output of the built model. Here, ArpNavigator, a molecular viewer tightly integrated into the ARP/wARP automated model-building package, is presented that directly controls model building and displays the evolving output in real time in order to make the procedure transparent to the user.

    Andere Autor:innen
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  • Use of noncrystallographic symmetry for automated model building at medium to low resolution

    Acta Cryst. D

    A novel method is presented for the automatic detection of noncrystallographic symmetry (NCS) in macromolecular crystal structure determination.

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Kurse

  • EMBL-EIPP Predoc Course 2008

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Sprachen

  • English

    Verhandlungssicher

  • Latin

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  • German

    Muttersprache oder zweisprachig

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