Alexander Dennig, Dr.

I personally used the optical tweezer for the isolation of a #methanogen and a sulfate-reducing #bacterium that were enriched in a stable, #biofilm-forming co-culture from an acient oil well in Costa Rica: #Methanobacterium cahuitense and #Desulfomicrobium aggregans. Due to the dense #biofilms, it was impossible to separate the individual cells by classical cell isolation strategies like serial dilution or plating. Thanks to this wonderful single-cell separation tool, I could successfully isolate and describe two novel species of anaerobic #microorganisms! #OilWell #CostaRica #CoCulture #MixedCulture #Archaea #SRB #SulfateReducer #SulfateReducingBacteria #OpticalTweezer

🎤 In an interview by Schweizer Bauer with the head of a plant biology laboratory at the University of Freiburg, Dr. Hazak, the statement that drew my attention was: “Many people are convinced that nature is perfect and that researchers are confusing everything” https://lnkd.in/eba79fwd   👩‍🔬 This reflects what many scientists feel and is based on oblivion that our current agricultural crops are not natural but based on centuries of selection. Dr. Hazak correctly notes that due to climate change the time for adapting plants is becoming shorter and therefore we should use techniques that allow us to accelerate the plant breeding process. #GiveCRISPRaChance 📽 If you understand German have a look at the nice videos linked to the article. #NewGenomicTechniques #GrowingTheFuture    

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In the current issue of BIOspektrum you will find an exciting article by Prof Dr Bernhard Hube, PI in our #ClusterOfExcellence! Hube talks about his research on human pathogenic fungi, with a particular focus on Candida species, as well as the progress made in understanding fungal infections and the development of new approaches to tackle these challenges. 📰 Read the interview here: https://lnkd.in/ezaUF697 🗞️... and the corresponding BIOspektrum article: https://lnkd.in/edgKHUts

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Interested in how early #formulationdevelopment and product characterization influence the drug development process? 🧪 Discover more in our on-demand webinar by Nadja Prang, MBA, Chief Scientific Officer at TECObiosciences GmbH: 🔗 𝗥𝗲𝗴𝗶𝘀𝘁𝗲𝗿 𝗵𝗲𝗿𝗲: https://lnkd.in/da7Np_E4 Dr. Nadja Prang, an expert in Pharmaceutical Product Development in the EU and US, advises on #CMC strategies, preclinical and clinical safety, and QC/QA for Biotech Product Development 🔑 ​𝐊𝐄𝐘 𝐓𝐀𝐊𝐄𝐀𝐖𝐀𝐘𝐒: Significant changes after light stress and de-amidation stress at 40°C Increased visible and sub-visible particles with low pH stress Minor changes with thermal, freeze-thaw, oxidative, and mechanical stress HSA-fusion protein is most affected by light and high pH stress Boost your #biotech product development knowledge today! 💡🌟 #PharmaceuticalDevelopment #CMC #DrugDevelopment #FormulationDevelopment #ProductCharacterization #BiotechWebinar #PharmaExpert #CMCStrategies #QualityControl #QualityAssurance #Biopharma #BiotechInnovation #HealthcareScience

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🔬 In the rapidly evolving field of biopharmaceuticals, robust and efficient monitoring of monoclonal antibody (mAb) heterogeneity is crucial for ensuring product safety and efficacy. A recent study from researchers at the Indian Institute of Technology, Delhi introduces an innovative 2D-LC/MS method for simultaneous titer and charge variant estimation of mAbs. ✨ This new method combines Protein-A chromatography for titer estimation and cation-exchange chromatography for charge variant analysis in a single, streamlined workflow. By utilizing volatile salts, this technique enables seamless mass spectrometry (MS) coupling, significantly reducing the analysis time to just 15 minutes per sample. 𝐊𝐞𝐲 𝐓𝐚𝐤𝐞-𝐚𝐰𝐚𝐲𝐬: • 🔗 𝐈𝐧𝐭𝐞𝐠𝐫𝐚𝐭𝐞𝐝 𝐖𝐨𝐫𝐤𝐟𝐥𝐨𝐰: Combines Protein-A chromatography and cation-exchange chromatography. • ⏱️ 𝐄𝐟𝐟𝐢𝐜𝐢𝐞𝐧𝐜𝐲: Reduces analysis time to 15 minutes per sample. • 🔄 𝐕𝐞𝐫𝐬𝐚𝐭𝐢𝐥𝐢𝐭𝐲: Applicable for both innovator and biosimilar mAbs. • 🎯 𝐏𝐫𝐞𝐜𝐢𝐬𝐢𝐨𝐧: Achieves high-resolution characterization of charge variants. For those involved in biopharmaceutical development, this approach offers a promising tool for more efficient and accurate mAb analysis. 🔗 https://lnkd.in/emCbjkgm #Biopharmaceuticals #MonoclonalAntibodies #MassSpectrometry #2DLC #BiotechInnovation #PharmaceuticalResearch #Biotech Deepika Sarin, Dr.Sunil Kumar, Anurag Rathore

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📢 #PrecisionFermentation Review Published in @MDPIOpenAccess Journal! We are thrilled to announce the publication of our latest scientific review article in the prestigious Fermentation MDPI journal! The article, titled "Precision Fermentation as an Alternative to Animal Protein, a Review," delves into the revolutionary potential of precision fermentation as a viable and sustainable alternative to animal protein. In this work, we cover: 🔬 The technological advancements driving precision fermentation 🌱 The environmental and ethical benefits of replacing animal proteins with fermented alternatives 📈 The market opportunities and promising future of this innovative technology We are immensely grateful to all co-authors Débora Trichez, jaciane and Boris Stambuk who made this paper possible. Ours sincere thanks to Universidade Federal de Santa Catarina and Fapesc who supported this project. We are eager to see how our insights will contribute to the advancement of science and the sustainable transformation of the food industry. 👉 Access the full article and learn more about this revolution in alternative proteins: https://lnkd.in/d7_J-ewC #PrecisionFermentation #AlternativeProtein #Sustainability #cellularagriculture #GFI #GFIbrasil #ABBI #precisionfermentationalliance

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#WorldDayForLaboratoryAnimals Conducting scientific research that involves animal experiments is a complex endeavor, but inevitable for advancing our understanding of infection processes and development of new therapeutics. At Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie - Hans-Knöll-Institut, we ensure utmost care for every creature under our watch. As we prioritize animal welfare, using strict ethical guidelines, quality controls, and alternative techniques, we aim to minimize the overall need for animal experiments. To learn more about animal experiments at Leibniz-HKI, please visit: https://lnkd.in/euWg2DZm 🐾 🐁❤️Always taking the best care possible for our mice: Ilse D. Jacobsen and Alessia Montesano   Deutsche Forschungsgemeinschaft (DFG) - German Research Foundation #AnimalWelfare #Transparency

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Are you working with microbial strains and struggling to compare results? Check out our NFDI4Microbiota Use Case: Strain-ID – your one-stop shop for strain identity information. This service created by Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH resolves culture collection numbers and streamlines the strain matching process. Discover corresponding strains effortlessly and integrate valuable information into your analysis. Simplify your research journey! ▶ Visit https://lnkd.in/ec32Jbrx for more info! #DMSZ #Microbiology #StrainInfo #NFDI4Microbiota #culturecollectionnumbers #persistentidentifier #microbialstrains #database

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𝗗𝗲𝘀𝗶𝗴𝗻𝗲𝗿 𝗽𝗿𝗼𝘁𝗲𝗶𝗻 𝗮𝗴𝗮𝗶𝗻𝘀𝘁 𝗵𝗼𝘀𝗽𝗶𝘁𝗮𝗹 #𝗴𝗲𝗿𝗺𝘀: In recent years, HYpharm GmbH has worked with university partners and with the support of the German Center for Infection Research (DZIF) to further develop and investigate the active ingredient HY-133. HY-133 is a novel protein that originally comes from bacteriophages - viruses that only infect bacteria. The Friedrich Loeffler Institute for Medical Microbiology at the University Medical Center Greifswald has extensively tested the substance for its effectiveness. The first clinical phase is now underway to test whether the active substance is safe and tolerable for healthy people. The active substance is an artificially produced and improved bacteriophage lysis protein that can quickly and effectively eliminate the bacterial infection pathogen Staphylococcus aureus, including multi-resistant strains (MRSA, methicillin-resistant S. aureus), in a highly specific manner. Around one in three people have the bacterium Staphylococcus aureus in their nose. If nasal colonization is treated prophylactically before hospitalization, the spread of MRSA in hospitals and the risk of infection with this pathogen in patients can be minimized. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: https://lnkd.in/eMkjQFn4 Deutsches Zentrum für Infektionsforschung (DZIF), Friedrich-Loeffler-Institut, Universitätsmedizin Greifswald, Karsten Becker, Ingrid Wanninger, Eberhard Karls Universität Tübingen, Andreas Peschel

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📢 Pentixapharm AG Acquires Target Discovery Business of Glycotope GmbH, effective July 1st.  This strategic acquisition of the Berlin-based biotech company marks a significant milestone in their mission to develop novel targeted radiopharmaceuticals against a broad range of malignancies. 🌟 𝗞𝗲𝘆 𝗛𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁𝘀 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗰𝗾𝘂𝗶𝘀𝗶𝘁𝗶𝗼𝗻: • 𝗖𝗼𝗺𝗽𝗿𝗲𝗵𝗲𝗻𝘀𝗶𝘃𝗲 𝗣𝗼𝗿𝘁𝗳𝗼𝗹𝗶𝗼: The deal includes a portfolio of 𝗽𝗿𝗲𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗮𝗻𝘁𝗶𝗯𝗼𝗱𝗶𝗲𝘀 against multiple oncology targets, 𝗹𝗮𝗯𝗼𝗿𝗮𝘁𝗼𝗿𝗶𝗲𝘀, cell banks, a 𝘁𝘂𝗺𝗼𝗿 𝘁𝗮𝗿𝗴𝗲𝘁 𝗱𝗮𝘁𝗮𝗯𝗮𝘀𝗲, and essential equipment.    • 𝗘𝗻𝗵𝗮𝗻𝗰𝗲𝗱 𝗜𝗻𝘁𝗲𝗹𝗹𝗲𝗰𝘁𝘂𝗮𝗹 𝗣𝗿𝗼𝗽𝗲𝗿𝘁𝘆: This acquisition broadens the 𝗜𝗣 𝗽𝗼𝗿𝘁𝗳𝗼𝗹𝗶𝗼 beyond the CXCR4 receptor, 𝗱𝗼𝘂𝗯𝗹𝗶𝗻𝗴 the 𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁 𝗽𝗶𝗽𝗲𝗹𝗶𝗻𝗲 and expanding business and clinical opportunities.    • 𝗘𝘅𝗽𝗲𝗿𝘁 𝗧𝗲𝗮𝗺: Pentixapharm welcomes an 𝗶𝗻𝘁𝗲𝗴𝗿𝗮𝘁𝗲𝗱 𝘁𝗲𝗮𝗺 𝗼𝗳 𝟰𝟬 seasoned executives, R&D specialists, and administrators from Glycotope.    • 𝗟𝗲𝗮𝗱𝗲𝗿𝘀𝗵𝗶𝗽 𝗘𝘅𝗽𝗮𝗻𝘀𝗶𝗼𝗻: Patrik Kehler, former CSO of Glycotope, will join as Pentixapharm's 𝗖𝗦𝗢, and Henner Kollenberg, former CEO of Glycotope, will become the 𝗖𝗵𝗶𝗲𝗳 𝗕𝘂𝘀𝗶𝗻𝗲𝘀𝘀 𝗢𝗳𝗳𝗶𝗰𝗲𝗿.    💬 𝗜𝗻𝘀𝗶𝗴𝗵𝘁𝘀 𝗳𝗿𝗼𝗺 𝗣𝗲𝗻𝘁𝗶𝘅𝗮𝗽𝗵𝗮𝗿𝗺'𝘀 𝗟𝗲𝗮𝗱𝗲𝗿𝘀: “Glycotope’s pipeline comprises 𝘀𝗲𝘃𝗲𝗿𝗮𝗹 𝗰𝗮𝗻𝗱𝗶𝗱𝗮𝘁𝗲𝘀 that can be 𝘂𝘀𝗲𝗱 𝗶𝗺𝗺𝗲𝗱𝗶𝗮𝘁𝗲𝗹𝘆 for 𝗽𝗿𝗼𝗼𝗳-𝗼𝗳-𝗰𝗼𝗻𝗰𝗲𝗽𝘁 𝘀𝘁𝘂𝗱𝗶𝗲𝘀 as next generation radiopharmaceuticals,” said Dr. Hakim Bouterfa, CEO of Pentixapharm AG. “We look forward to 𝗺𝗮𝘅𝗶𝗺𝗶𝘇𝗶𝗻𝗴 𝘁𝗵𝗲 𝘀𝘆𝗻𝗲𝗿𝗴𝘆 of Pentixapharm’s know-how and Glycotope’s target discovery for the 𝗯𝗲𝗻𝗲𝗳𝗶𝘁 𝗼𝗳 𝗽𝗮𝘁𝗶𝗲𝗻𝘁𝘀 in both diagnostics and therapeutic applications.” “The transaction 𝘀𝘁𝗿𝗲𝗻𝗴𝘁𝗵𝗲𝗻𝘀 our 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗽𝗶𝗽𝗲𝗹𝗶𝗻𝗲 and administrative capacities, facilitating a 𝘀𝗲𝗮𝗺𝗹𝗲𝘀𝘀 𝘁𝗿𝗮𝗻𝘀𝗶𝘁𝗶𝗼𝗻 to the 𝗙𝗿𝗮𝗻𝗸𝗳𝘂𝗿𝘁 𝗦𝘁𝗼𝗰𝗸 𝗘𝘅𝗰𝗵𝗮𝗻𝗴𝗲,” noted 𝗗𝗿. 𝗔𝗻𝗱𝗿𝗲𝗮𝘀 𝗘𝗰𝗸𝗲𝗿𝘁, Chairman of the Supervisory Board of both Pentixapharm and Eckert & Ziegler SE. This acquisition positions Pentixapharm to develop 𝗶𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝘃𝗲 𝗿𝗮𝗱𝗶𝗼𝗽𝗵𝗮𝗿𝗺𝗮𝗰𝗲𝘂𝘁𝗶𝗰𝗮𝗹𝘀 by leveraging Glycotope’s 𝘂𝗻𝗶𝗾𝘂𝗲 𝗚𝗹𝘆𝗰𝗼𝗧𝗮𝗿𝗴𝗲𝘁𝘀—tumor-associated 𝗰𝗮𝗿𝗯𝗼𝗵𝘆𝗱𝗿𝗮𝘁𝗲 𝘀𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗲𝘀 with 𝘀𝘂𝗽𝗲𝗿𝗶𝗼𝗿 𝘁𝘂𝗺𝗼𝗿-𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰𝗶𝘁𝘆. These advancements have the potential to close the treatment gap for many solid tumors, enhancing both diagnostic and therapeutic applications. 🔗 Learn More: https://lnkd.in/eCXh35Nw #NuclearMedicine #Radiopharmaceuticals #Acquisition #PrecisionMedicine  

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The science of fermentation Learn about the emerging role of microbial fermentation in building the next generation of alternative protein products Source: GFI #fermentation #precisionfermentation #alternativeprotein #smartprotein

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📺 You missed the #BIOPOLYMERCongress2024 but are keenly interested in the lectures? Then check out our #YouTube channel now. Here you will find all the presentations from 2024 as recordings: https://lnkd.in/e3ngPpz2 #biopolymer #biopolymercongress #thinkgreen 💚

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🌟 New Tool for Microbial Research: MicrobioRaman 🌟    This groundbreaking open access platform – just published in Nature Microbiology – provides unprecedented access to comprehensive #Raman #spectroscopy data on microscopic life forms such as bacteria, viruses, and fungi. It was developed by an international team, including expertise from Leibniz IPHT. 👏    MicrobioRaman enables scientists worldwide to     🧬 Develop new medical treatments by analyzing microbial interactions.   🌍 Understand the role of microbes in ecosystems.   🚀 Explore the potential for life on other planets.    "MicrobioRaman provides comprehensive Raman data and facilitates global data sharing and comparison, accelerating research collaboration and driving advances in medical and pharmaceutical solutions," emphasizes Prof. Juergen Popp.   Check out the comments to learn more ⬇️ Nature Portfolio

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Baylab is a global project through which Bayer opens doors to students to discover science with fun. We design experiments where kids feel like little scientists for a day, since they will be the scientists of tomorrow. This year, on the occasion of “Fascination of Plants Day” Bayer is welcoming more than 80 children who are doing two hands-on workshops. Through these workshops, Baylab intends to: Increase interest among young people in our region towards science and plants. Emphasize the importance of resistant varieties against diseases. Introduce students to genetic and DNA field, since they will be able to observe the double-helix structure that they previously extracted. Foster the development of lab skills and evaluation of the resistance among pathogens. Montse Jimenez #baylab #baylabspain #bayercropscience #fascinationofplantsday #seminisiberia #cientificosdelmañana

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A really interesting article from SynBioBeta highlighting the use of non-model organisms to rapidly expand the applications of #SyntheticBiology in #sustainability #HumanHealth and #Industrial applications. It includes a quote from Seemay Chou from Arcadia Science that really resonates: “Maybe the way to increase scaling ability by an order of magnitude is not to make E. coli slightly different. It could be to start from a totally different chassis that might have better ingredients for success,” Our ŌGI BioReactor is designed to provide the flexibility that is crucial in adapting current technology to growing these less well understood organisms. Over the last month or so we've been at several events where the diversity of organisms being investigated has been on show and it's been really fantastic to hear how the ŌGI BioReactor can enable innovation with complex and non-model systems. If you want to learn more than reach out at our website www.ogibio.co.uk or come and see us in person next week at the Society for Industrial Microbiology and Biotechnology's Annual Conference in #Boston. Matthew Scheier, PhD and Alex McVey will be around all week to discuss your #fermentation and #microbial culturing needs. #SyntheticBiology #EngineeringBiology #SIMB2024 MassBio https://lnkd.in/gpJ_MKKZ

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🌟📑 #SuperSupplements: Use and Mis-Use of Supplementary Materials ✅🚫    Today, we dive into the editorial by Pop and Salzburg (2015) in BMC Bioinformatics, discussing the roles and pitfalls of supplementary materials in research. Let's explore...   🔍 Key Questions Addressed: - Why is supplementary material needed? - Is supplementary material being reviewed? - Is supplementary material easy to use?   ⚠️ Threat to Scientific Review Process: "The increasing reliance on supplementary materials threatens the scientific review process." A recent Nature paper caused a storm, with some naming such misuse as DOPRA: Denial of Peer Review Attack. #PeerReview #ResearchIntegrity [source](https://lnkd.in/ejy4DPni)   🔍 **Superficial Reviews:** "Often, supplementary materials are reviewed superficially or not at all." Insights from our previous discussions confirm this issue, highlighting the need for better review practices. #AcademicStandards [Previous X thread](https://lnkd.in/eN2ew8Fv)   📚 Hidden Citations: "Citations buried within supplementary files rob other scientists of recognition." Proper acknowledgment is essential for maintaining the scientific record. #CitationsMatter   This invisibility is a well-recorded phenomenon. Here are just a few articles: [1] Seeber: [link](https://lnkd.in/efcY4ZpM) [2] Weiss et al.: [link](https://lnkd.in/eVdZVS-p) [3] Kenyon and Sprague: [link](https://lnkd.in/ecJ8GJAQ)   📃 Circumventing Page Limits: "Supplements are often used to circumvent page limits imposed by journals." Authors suggest Supplementary Information should instead be a “compromise between readability and reproducibility." #PublishingStandards   🔄 Ensuring Reproducibility: "Properly curated supplementary materials are essential for ensuring reproducibility." Open science depends on accessible and well-documented data. #OpenScience #Reproducibility   📚 International Consensus: There appears to be international agreement on this issue with both the National Information Standards Organization and the National Federation of Advanced Information Services reporting on supplementary materials. #FurtherReading [source](https://lnkd.in/ebvmmuUc)   📋 Action 1: Comprehensive citation practices within the main article. #AcademicIntegrity   🔗 Action 2: Make accessing additional data seamless and user-friendly. #InteractiveResearch   💾 For example, provide data tables in computer-readable formats like plain text or spreadsheets and avoid PDF-only formats for supplementary tables. #DataAccessibility   👓 Check out the Editorial and let us know what you think! https://lnkd.in/eYgAax9B   👀 Next time: Spotlight on Statistics We delve into how scientific journals can dedicate extensive sections to biological methods with careful justification, yet only a single paragraph to statistical methods. #SuperSupplements

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WHITE PAPER | Determination of Particles in Pharmaceutical Formulations In our new white paper, Dr. Peter Muehlschlegel, Project Manager Analytical Testing, addresses the regulatory context and challenges of particulate identification. Dr. Muehlschlegel introduces effective testing strategies through a series of case studies, offering practical solutions based on the type and source of observed particulate contamination. Download now: https://lnkd.in/ekzZkryw #DrugDevelopment #DrugSafety #WhitePaper #pharma #Intertek

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Is an unsolvable solution worth pursuing? As part of a product development team of biological scientists, we strive to always further our understanding of our product. The product is biological, and applied to a biological organism. The story of how it works is therefore complicated, and the relation between biology and environment is complicated. Will we ever know the complete story? As a product development scientist, this is my long term goal, ever optimistic (a yes) but also a realist (so maybe a no). As a team leader, I like to push my team and myself to see how much of these questions we can answer, or at least delve into insight. The more we scientists know, the more improved our commercial team can sell a marketing story that is accurate. So, it was interesting this year when we stumbled on a very unforseen conundrum. I am determined to find out the Why and How. However, we have been questioned on 'the problem is far too complex'; and 'do you think the competitors have also not tried to find a solution, and they haven't yet?'. My advice to other P.D. scientists is to not despair with such comments. Don't get emotional but remain calm. Ask why is it 'too complex?'. A negative feedback gives you insight on previous failures in the subject, and can drive you to a more positive outcome. Yes, it might be very complex, but each little discovery adds more to the story. Maybe you find a solution, but maybe you find out something about your product you never knew. It all counts in the end. Keep pursuing, don't despair, and keep your team positively motivated.

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Joint Webinar with acib GmbH presenting new data about how chromatin affects your bioprocessing> https://lnkd.in/dfvwgZWy For maximum #dnaclearing of your #viralvectors and #bioprocessing this our SAN nucleases are a #paradigmshift for #genetherapy #therapeutics #bioprocessing #vaccines #oncolyticviruses #lentivirus #adenoassociatedvirus #AAV

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