Lausanne, Waadt, Schweiz
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Berufserfahrung und Ausbildung
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Limula
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Bescheinigungen und Zertifikate
Ehrenamt
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Co-founder and President
Hackuarium
– 5 Jahre 1 Monat
Science and Technology
I imagined and co-created the Hackuarium in the spring 2014. I subsequently led the association as its President over its first 3 years of existence, and later as its secretary for another 2 years. Hackuarium is an initiative that promotes open and collaborative research and development at the interface of biology, technology and the arts. It is a vibrant community of like-minded and curious people, biologists, engineers, computer scientists, but also artists, designers and other profiles…
I imagined and co-created the Hackuarium in the spring 2014. I subsequently led the association as its President over its first 3 years of existence, and later as its secretary for another 2 years. Hackuarium is an initiative that promotes open and collaborative research and development at the interface of biology, technology and the arts. It is a vibrant community of like-minded and curious people, biologists, engineers, computer scientists, but also artists, designers and other profiles, ready to engage in challenging projects. It is also a physical laboratory where 'amateurs' can perform experiments and test their ideas with the support of other members of the community. More information here: http://wiki.hackuarium.ch/w/Main_Page
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Event Assistant
LIFT
– 1 Monat
Science and Technology
To get a privileged insight into a world-class event that explores the business and social implications of technological innovation, I enrolled as a volunteer to help run the 2014 of the LIFT conference in Geneva (http://liftconference.com/lift14). I was responsible for welcoming participants from all over the world, and other practical aspects during the 3-days conference.
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Conference Organizer and Chair
Life Sciences Switzerland (LS2)
– 2 Monaten
Science and Technology
I was in charge of organising, planning and chairing the Ethics session of the 2014 Life Science Switzerland annual meeting (http://www.ls2-annual-meeting.ch). This task included editorial work for building a scientific program, contacting potential speakers, coordinating the session, chairing the session and the roundtable that followed
Veröffentlichungen
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Rebels or profiteers?
Science / AAAS
Veröffentlichung anzeigen“Open,” the new black of political controversy, has become ubiquitous in contemporary
debates surrounding scientific practices. Just as software activists managed to free
information technologies from the realms of academia and industry, today some biologists
believe their science would have a larger impact if carried out in the open. However, most
scientists still have a narrow conception of where the “open revolution” comes from and what
it means. -
The Enzymes of beta-lactam Biosynthesis
Natural Product Reports
The β-lactam antibiotics and related β-lactamase inhibitors are amongst the most important small molecules in clinical use. Most, but not all, β-lactams including penicillins, cephalosporins, and clavulanic acid are produced via fermentation or via modification of fermented intermediates, with important exceptions being the carbapenems and aztreonam. The desire for more efficient routes to existing antibiotics and for access to new and synthetically challenging ones stimulates continued…
The β-lactam antibiotics and related β-lactamase inhibitors are amongst the most important small molecules in clinical use. Most, but not all, β-lactams including penicillins, cephalosporins, and clavulanic acid are produced via fermentation or via modification of fermented intermediates, with important exceptions being the carbapenems and aztreonam. The desire for more efficient routes to existing antibiotics and for access to new and synthetically challenging ones stimulates continued interest in β-lactam biosynthesis. We review knowledge of the pathways leading to β-lactam antibiotics focusing on the mechanisms, structures and biocatalytic applications of the enzymes involved.
Andere Autor:innen -
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Crotonase Catalysis Enables Flexible Production of Functionalized Prolines and Carbapenams
Journal of the American Chemical Society
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Structural and mechanistic studies on γ-butyrobetaine hydroxylase
Chemistry & Biology / Cell Press
The final step in carnitine biosynthesis is catalyzed by γ-butyrobetaine (γBB) hydroxylase
(BBOX), an iron/2-oxoglutarate (2OG) dependent oxygenase. BBOX is inhibited by
trimethylhydrazine-propionate (THP), a clinically used compound. We report structural and
mechanistic studies on BBOX and its reaction with THP. Crystallographic and sequence
analyses reveal that BBOX and trimethyllysine hydroxylase form a subfamily of 2OG
oxygenases that dimerize using an N-terminal domain.Andere Autor:innen -
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