About
Contributions
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What do you do if your R&D team needs to improve problem solving with data analysis?
Focus on skill enhancement- Offer training sessions covering advanced techniques and tools like statistical methods, predictive modeling, etc. Encourage regular knowledge-sharing to foster learning from each other's experiences and findings, enhancing their ability to interpret data effectively and derive meaningful insights. Organize workshops to conduct training sessions. Apart from this also regularly review team's team's data analysis practices for continuous improvement.
Activity
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Very pleased that ONWARD Medical is one of the pioneering investments of SCI Ventures. Christopher & Dana Reeve Foundation President Maggie Goldberg…
Very pleased that ONWARD Medical is one of the pioneering investments of SCI Ventures. Christopher & Dana Reeve Foundation President Maggie Goldberg…
Liked by Neha Bhutani, PhD
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Gabrielle Von and I always love getting a chance to present our neuroscience board game—thank you Centre for Research on Brain, Language and Music…
Gabrielle Von and I always love getting a chance to present our neuroscience board game—thank you Centre for Research on Brain, Language and Music…
Liked by Neha Bhutani, PhD
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A big thank you to MaRS Discovery District and Nirali Rawthra for hosting the Trailblazing Women in Healthcare event last night. Valuable insights…
A big thank you to MaRS Discovery District and Nirali Rawthra for hosting the Trailblazing Women in Healthcare event last night. Valuable insights…
Liked by Neha Bhutani, PhD
Experience & Education
Licenses & Certifications
Volunteer Experience
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Social media and Outreach committee Volunteer
Canadian Science Policy Centre
- 1 year 1 month
Science and Technology
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Volunteer
Brain Awareness Montreal
- 1 year 1 month
Education
Raising awareness in primary and secondary school students about interesting aspects of neuroscience.
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Co-organizer for Scientific Cafe title Neuroscience of Aging.
Brain Awareness Montreal
- Present 9 years 3 months
Health
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Publications
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Investing in young researchers to strengthen Canada’s future
Canadian Science Policy Centre Editorial
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Parallel activation of prospective motor plans during visually-guided sequential saccades
European Journal of Neuroscience
Behavioural evidences suggest that sequential saccades to multiple stimuli are planned in parallel. However, it remains unclear whether such parallel programming reflects concurrent processing of goals or whether multiple motor plans coexist, unfolding subsequently during execution. Here we use midway saccades, directed at intermediate locations between two targets, as a probe to address this question in a novel double-step adaptation task. The task consisted of trials where subjects had to…
Behavioural evidences suggest that sequential saccades to multiple stimuli are planned in parallel. However, it remains unclear whether such parallel programming reflects concurrent processing of goals or whether multiple motor plans coexist, unfolding subsequently during execution. Here we use midway saccades, directed at intermediate locations between two targets, as a probe to address this question in a novel double-step adaptation task. The task consisted of trials where subjects had to follow the appearance of two targets presented in succession with two sequential saccades. In some trials, the second target predictably jumped to a new location during the second saccade. Initially, the second saccade was aimed at the final target's location before the jump. As subjects adapted to the target jump, saccades were aimed to the second target's new location. We tested whether the spatial distribution of midway saccades could be explained as an interaction between two concurrent saccade goals, each directed at the two target locations, or between the initial motor plan to the first target location and a prospective motor plan directed from the initial to the final target location. A shift in the midway saccades' distribution towards the jumped location of the second target following adaptation indicated that the brain can make use of prospective motor plans to guide sequential eye movements. Furthermore, we observed that the spatiotemporal pattern of endpoints of midway saccades can be well explained by a motor addition model. These results provide strong evidence of parallel activation of prospective motor plans during sequential saccades.
Other authorsSee publication -
Queuing of concurrent movement plans by basal ganglia.
The Journal of Neuroscience
How the brain converts parallel representations of movement goals into sequential movements is not known. We tested the role of basal ganglia (BG) in the temporal control of movement sequences by a convergent approach involving inactivation of the BG by muscimol injections into the caudate nucleus of monkeys and assessing behavior of Parkinson's disease patients, performing a modified double-step saccade task. We tested a critical prediction of a class of competitive queuing models that…
How the brain converts parallel representations of movement goals into sequential movements is not known. We tested the role of basal ganglia (BG) in the temporal control of movement sequences by a convergent approach involving inactivation of the BG by muscimol injections into the caudate nucleus of monkeys and assessing behavior of Parkinson's disease patients, performing a modified double-step saccade task. We tested a critical prediction of a class of competitive queuing models that explains serial behavior as the outcome of a selection of concurrently activated goals. In congruence with these models, we found that inactivation or impairment of the BG unmasked the parallel nature of goal representations such that a significantly greater extent of averaged saccades, curved saccades, and saccade sequence errors were observed. These results suggest that the BG perform a form of competitive queuing, holding the second movement plan in abeyance while the first movement is being executed, allowing the proper temporal control of movement sequences.
Other authorsSee publication -
Is saccade averaging determined by visual processing or movement planning?
Journal of Neurophysiology
Saccadic averaging that causes subjects' gaze to land between the location of two targets when faced with simultaneously or sequentially presented stimuli has been often used as a probe to investigate the nature of computations that transform sensory representations into an oculomotor plan. Since saccadic movements involve at least two processing stages—a visual stage that selects a target and a movement stage that prepares the response—saccade averaging can either occur due to interference in…
Saccadic averaging that causes subjects' gaze to land between the location of two targets when faced with simultaneously or sequentially presented stimuli has been often used as a probe to investigate the nature of computations that transform sensory representations into an oculomotor plan. Since saccadic movements involve at least two processing stages—a visual stage that selects a target and a movement stage that prepares the response—saccade averaging can either occur due to interference in visual processing or movement planning. By having human subjects perform two versions of a saccadic double-step task, in which the stimuli remained the same, but different instructions were provided (REDIRECT gaze to the later-appearing target vs. FOLLOW the sequence of targets in their order of appearance), we tested two alternative hypotheses. If saccade averaging were due to visual processing alone, the pattern of saccade averaging is expected to remain the same across task conditions. However, whereas subjects produced averaged saccades between two targets in the FOLLOW condition, they produced hypometric saccades in the direction of the initial target in the REDIRECT condition, suggesting that the interaction between competing movement plans produces saccade averaging.
Other authorsSee publication -
Mutual inhibition and capacity sharing during parallel preparation of serial eye movements.
Journal of Vision
Many common activities, like reading, scanning scenes, or searching for an inconspicuous item in a cluttered environment, entail serial movements of the eyes that shift the gaze from one object to another. Previous studies have shown that the primate brain is capable of programming sequential saccadic eye movements in parallel. Given that the onset of saccades directed to a target are unpredictable in individual trials, what prevents a saccade during parallel programming from being executed in…
Many common activities, like reading, scanning scenes, or searching for an inconspicuous item in a cluttered environment, entail serial movements of the eyes that shift the gaze from one object to another. Previous studies have shown that the primate brain is capable of programming sequential saccadic eye movements in parallel. Given that the onset of saccades directed to a target are unpredictable in individual trials, what prevents a saccade during parallel programming from being executed in the direction of the second target before execution of another saccade in the direction of the first target remains unclear. Using a computational model, here we demonstrate that sequential saccades inhibit each other and share the brain's limited processing resources (capacity) so that the planning of a saccade in the direction of the first target always finishes first. In this framework, the latency of a saccade increases linearly with the fraction of capacity allocated to the other saccade in the sequence, and exponentially with the duration of capacity sharing. Our study establishes a link between the dual-task paradigm and the ramp-to-threshold model of response time to identify a physiologically viable mechanism that preserves the serial order of saccades without compromising the speed of performance.
Other authorsSee publication -
Impaired conflict monitoring in Parkinson's disease patients during an oculomotor redirect task
Experimental Brain Research
Fallibility is inherent in human cognition and so a system that will monitor performance is indispensable. While behavioral evidence for such a system derives from the finding that subjects slow down after trials that are likely to produce errors, the neural and behavioral characterization that enables such control is incomplete. Here, we report a specific role for dopamine/basal ganglia in response conflict by accessing deficits in performance monitoring in patients with Parkinson's disease…
Fallibility is inherent in human cognition and so a system that will monitor performance is indispensable. While behavioral evidence for such a system derives from the finding that subjects slow down after trials that are likely to produce errors, the neural and behavioral characterization that enables such control is incomplete. Here, we report a specific role for dopamine/basal ganglia in response conflict by accessing deficits in performance monitoring in patients with Parkinson's disease. To characterize such a deficit, we used a modification of the oculomotor countermanding task to show that slowing down of responses that generate robust response conflict, and not post-error per se, is deficient in Parkinson's disease patients. Poor performance adjustment could be either due to impaired ability to slow RT subsequent to conflicts or due to impaired response conflict recognition. If the latter hypothesis was true, then PD subjects should show evidence of impaired error detection/correction, which was found to be the case. These results make a strong case for impaired performance monitoring in Parkinson's patients.
Other authorsSee publication -
Trans-saccadic processing of visual and motor planning during sequential eye movements.
Experimental Brain Research
How the brain maintains perceptual continuity across eye movements that yield discontinuous snapshots of the world is still poorly understood. In this study, we adapted a framework from the dual-task paradigm, well suited to reveal bottlenecks in mental processing, to study how information is processed across sequential saccades. The pattern of RTs allowed us to distinguish among three forms of trans-saccadic processing (no trans-saccadic processing, trans-saccadic visual processing and…
How the brain maintains perceptual continuity across eye movements that yield discontinuous snapshots of the world is still poorly understood. In this study, we adapted a framework from the dual-task paradigm, well suited to reveal bottlenecks in mental processing, to study how information is processed across sequential saccades. The pattern of RTs allowed us to distinguish among three forms of trans-saccadic processing (no trans-saccadic processing, trans-saccadic visual processing and trans-saccadic visual processing and saccade planning models). Using a cued double-step saccade task, we show that even though saccade execution is a processing bottleneck, limiting access to incoming visual information, partial visual and motor processing that occur prior to saccade execution is used to guide the next eye movement. These results provide insights into how the oculomotor system is designed to process information across multiple fixations that occur during natural scanning.
Other authorsSee publication
Projects
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Pixelles Game Incubator
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A solo project to make a video game in Unity 3D where game mechanics are controlled by eye tracker (Tobii).
Honors & Awards
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Fonds de recherche du Québec - Santé (FRQS) Postdoctoral Fellowship
FRQS
I have post-doctoral fellowship from Fonds de recherche du Québec - Santé (FRQS) for my current study titled: "Corrélats neuronaux de la modification simultanée des circuits de contrôle moteur en boucle ouverte (« feedforward ») et en boucle fermée (« feed-back ») du cortex cérébral lors de l'apprentissage de nouvelles tâches motrices"
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Travel award
Japan Neuroscience Society
Travel award to present poster on part of my PhD work at the Japan Neuroscience Society Conference in 2010.
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PhD fellowship
University Grants Commission, Government of India
I was funded for a period of 5 years for my PhD training.
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Graduate Aptitude Test in Enginnering in Life Sciences (GATE)
National Coordination Board- GATE, Department of Higher Education, Ministry of Human Resource and Development (MHRD), Government of India
Secured 97.64 percentile in GATE-2005 in Life Sciences, conducted by the Indian Institute of Technology, Delhi, India
Languages
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English
Native or bilingual proficiency
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French
Elementary proficiency
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Hindi
Native or bilingual proficiency
More activity by Neha
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Excited to share our new Wireless ultra-small photocapacitive stimulation ultramicroelectrode. We show ways to enhance performance with polymers…
Excited to share our new Wireless ultra-small photocapacitive stimulation ultramicroelectrode. We show ways to enhance performance with polymers…
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Olympus Innovation Ventures (OIV) continues to support innovative medical technologies, investing in Neuspera Medical with the goal of enhancing…
Olympus Innovation Ventures (OIV) continues to support innovative medical technologies, investing in Neuspera Medical with the goal of enhancing…
Liked by Neha Bhutani, PhD
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Congratulations to Neuspera Medical Inc. a #neuromodulation company, has closed a Series D funding round, raising $23 million. This round led by…
Congratulations to Neuspera Medical Inc. a #neuromodulation company, has closed a Series D funding round, raising $23 million. This round led by…
Shared by Neha Bhutani, PhD
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The Alzheimer's Association® and National Institute Of Aging have released new criteria that signal an era of innovation in understanding…
The Alzheimer's Association® and National Institute Of Aging have released new criteria that signal an era of innovation in understanding…
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Brilliant news that Cohort 6 Clinical Entrepreneur Nick Gompertz and the team at EarSwitch are Medilink UK National Healthcare Business Award Winners…
Brilliant news that Cohort 6 Clinical Entrepreneur Nick Gompertz and the team at EarSwitch are Medilink UK National Healthcare Business Award Winners…
Liked by Neha Bhutani, PhD
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Neuspera Medical Inc. brings in $23M Series D! The #neuromod start-up plans to use the funds to get its urinary urge incontinence (UUI) implant…
Neuspera Medical Inc. brings in $23M Series D! The #neuromod start-up plans to use the funds to get its urinary urge incontinence (UUI) implant…
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In this paper published in Brain Stimulation, we (Mehrdad Bahadori and Simone Dalla Bella) investigated the impact of transcutaneous vagus nerve…
In this paper published in Brain Stimulation, we (Mehrdad Bahadori and Simone Dalla Bella) investigated the impact of transcutaneous vagus nerve…
Shared by Neha Bhutani, PhD
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The Centers for Medicare & Medicaid Services (CMS) proposed a new payment policy covering digital tools for behavioral health, which could benefit…
The Centers for Medicare & Medicaid Services (CMS) proposed a new payment policy covering digital tools for behavioral health, which could benefit…
Shared by Neha Bhutani, PhD
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Over the past decade, the pursuit of disease-modifying therapies for #Parkinsonsdisease (PD) has emphasized the need for accurate and objective…
Over the past decade, the pursuit of disease-modifying therapies for #Parkinsonsdisease (PD) has emphasized the need for accurate and objective…
Shared by Neha Bhutani, PhD
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We just announced a financing with Runway Growth Capital that gives us access to up to EUR 52.5M in additional capital over the next few years. The…
We just announced a financing with Runway Growth Capital that gives us access to up to EUR 52.5M in additional capital over the next few years. The…
Liked by Neha Bhutani, PhD
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It's Sunday.... Time for coffee and the weekly #MedTech News! Adona Medical raised a healthy $33 Mil towards their next-gen interatrial shunt and…
It's Sunday.... Time for coffee and the weekly #MedTech News! Adona Medical raised a healthy $33 Mil towards their next-gen interatrial shunt and…
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AI promises to revolutionize healthcare by enhancing diagnosis, treatment, and patient safety. Yet, a critical gap exists between AI research and its…
AI promises to revolutionize healthcare by enhancing diagnosis, treatment, and patient safety. Yet, a critical gap exists between AI research and its…
Liked by Neha Bhutani, PhD
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