About
Articles by Brad
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I had an incredible experience on public transit this morning: How often do you get to say that?
I had an incredible experience on public transit this morning: How often do you get to say that?
By Brad Davis, PhD
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A/B testing average spending for e-Commerce
A/B testing average spending for e-Commerce
By Brad Davis, PhD
Contributions
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How do you choose the right statistical test for your SPSS data analysis?
Does anyone still use SPSS? If so, why? R is better. Python is better. Minitab might be better. Hell, a slide rule and the formulas for different sums of squares is probably better. Everything is better, except maybe Excel. Let’s be honest, if you are using SPSS something drastically wrong has happened to your life.
Activity
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“A pharma company stopped using Microsoft's Copilot AI tool, with an exec citing high cost and low value.” “He compared the slide-generation…
“A pharma company stopped using Microsoft's Copilot AI tool, with an exec citing high cost and low value.” “He compared the slide-generation…
Liked by Brad Davis, PhD
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Here are some untold truths about Machine Learning careers. You won't learn about these in books ↓ 1/ In school, you spend 80% learning about ML…
Here are some untold truths about Machine Learning careers. You won't learn about these in books ↓ 1/ In school, you spend 80% learning about ML…
Liked by Brad Davis, PhD
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Back in 2004, Motorola Solutions Penang successfully established the first Penang Emergency Ambulance Radio Link (PEARL) in collaboration with the…
Back in 2004, Motorola Solutions Penang successfully established the first Penang Emergency Ambulance Radio Link (PEARL) in collaboration with the…
Liked by Brad Davis, PhD
Experience & Education
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Motorola Solutions
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Licenses & Certifications
Volunteer Experience
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President of Zoology Graduate Student's Association
The University of British Columbia
- 2 years 9 months
Education
I had two main responsibilities in my role as President of the Zoology Graduate Student's Association: organizing the annual Zoology Graduate Student's Association symposium (2003 and 2004), and the yearly New Student Orientation for all incoming graduate students into the department of Zoology (2004 and 2005). I also organized social activities, such as the yearly 'Pumpkin Carving Contest'.
Organizing the symposium required identifying and inviting an external speaker from another…I had two main responsibilities in my role as President of the Zoology Graduate Student's Association: organizing the annual Zoology Graduate Student's Association symposium (2003 and 2004), and the yearly New Student Orientation for all incoming graduate students into the department of Zoology (2004 and 2005). I also organized social activities, such as the yearly 'Pumpkin Carving Contest'.
Organizing the symposium required identifying and inviting an external speaker from another university in North America, as well as organizing their air travel and accommodations. Making arrangements with a local venue to host the symposium, motivating other graduate students to help with the preparations, and then delegating out individual responsibilities for tasks such as audio-visual set up, preparing for coffee breaks, and lunch.
I also participated in the new student orientation for incoming graduate students into the Zoology department. This included giving the incoming students tours of the facilities and introducing them to key people within the department. -
Bike to work week team leader
Roadhouse Interactive
- Present 9 years 4 months
Environment
I set up and organized Roadhouse Interactive's first Bike To Work week team. I registered our team with the Bike Hub (www.bikehub.ca) and set a goal of encouraging 25 co-workers to join the team and participate in Bike To Work week. I also set a goal of winning the 'Rookie Team' award, given to the largest new team in any given year, Best Workplace for a company between 101 and 250 employees, and the Team Growth award.
I met my goal of getting at least 25 co-workers to sign up…I set up and organized Roadhouse Interactive's first Bike To Work week team. I registered our team with the Bike Hub (www.bikehub.ca) and set a goal of encouraging 25 co-workers to join the team and participate in Bike To Work week. I also set a goal of winning the 'Rookie Team' award, given to the largest new team in any given year, Best Workplace for a company between 101 and 250 employees, and the Team Growth award.
I met my goal of getting at least 25 co-workers to sign up, including encouraging two of my fellow employees to try commuting to work by bike for the first time.
Bike to Work week runs from May 25 until May 31st, 2015, and it's May 22nd, so I don't know if I've accomplished my other three awards goals yet.
Publications
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Comparative genomic and genetic analysis of glioblastoma-derived brain tumor-initiating cells and their parent tumors
Neuro-Oncology
See publicationBackground Glioblastoma (GBM) is a fatal cancer that has eluded major therapeutic advances. Failure to make progress may reflect the absence of a human GBM model that could be used to test compounds for anti-GBM activity. In this respect, the development of brain tumor-initiating cell (BTIC) cultures is a step forward because BTICs appear to capture the molecular diversity of GBM better than traditional glioma cell lines. Here, we perform a comparative genomic and genetic analysis of BTICs and…
Background Glioblastoma (GBM) is a fatal cancer that has eluded major therapeutic advances. Failure to make progress may reflect the absence of a human GBM model that could be used to test compounds for anti-GBM activity. In this respect, the development of brain tumor-initiating cell (BTIC) cultures is a step forward because BTICs appear to capture the molecular diversity of GBM better than traditional glioma cell lines. Here, we perform a comparative genomic and genetic analysis of BTICs and their parent tumors as preliminary evaluation of the BTIC model.
Methods We assessed single nucleotide polymorphisms (SNPs), genome-wide copy number variations (CNVs), gene expression patterns, and molecular subtypes of 11 established BTIC lines and matched parent tumors.
Results Although CNV differences were noted, BTICs retained the major genomic alterations characteristic of GBM. SNP patterns were similar between BTICs and tumors. Importantly, recurring SNP or CNV alterations specific to BTICs were not seen. Comparative gene expression analysis and molecular subtyping revealed differences between BTICs and GBMs. These differences formed the basis of a 63-gene expression signature that distinguished cells from tumors; differentially expressed genes primarily involved metabolic processes. We also derived a set of 73 similarly expressed genes; these genes were not associated with specific biological functions.
Conclusions Although not identical, established BTIC lines preserve the core molecular alterations seen in their parent tumors, as well as the genomic hallmarks of GBM, without acquiring recurring BTIC-specific changes. -
Epigenetic and transcriptional determinants of the human b
Nature Communications
While significant effort has been dedicated to the characterization of epigenetic changes associated with prenatal differentiation, relatively little is known about the epigenetic changes that accompany post-natal differentiation where fully functional differentiated cell types with limited lifespans arise. Here we sought to address this gap by generating epigenomic and transcriptional profiles from primary human breast cell types isolated from disease-free human subjects. From these data we…
While significant effort has been dedicated to the characterization of epigenetic changes associated with prenatal differentiation, relatively little is known about the epigenetic changes that accompany post-natal differentiation where fully functional differentiated cell types with limited lifespans arise. Here we sought to address this gap by generating epigenomic and transcriptional profiles from primary human breast cell types isolated from disease-free human subjects. From these data we define a comprehensive human breast transcriptional network, including a set of myoepithelial- and luminal epithelial-specific intronic retention events. Intersection of epigenetic states with RNA expression from distinct breast epithelium lineages demonstrates that mCpG provides a stable record of exonic and intronic usage, whereas H3K36me3 is dynamic. We find a striking asymmetry in epigenomic reprogramming between luminal and myoepithelial cell types, with the genomes of luminal cells harbouring more than twice the number of hypomethylated enhancer elements compared with myoepithelial cells.
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Being kind is a way of life, and not a strategy. It's easy to tell the difference.
Being kind is a way of life, and not a strategy. It's easy to tell the difference.
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Great day volunteering with our team at Motorola Solutions helping pack meal kits for kids and families missing out on school lunches during the…
Great day volunteering with our team at Motorola Solutions helping pack meal kits for kids and families missing out on school lunches during the…
Liked by Brad Davis, PhD
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