A Maltipoo is a cross between a Maltese and a Toy or Miniature Poodle. They are also sometimes called Malti-Poos, Maltipoos, Maltepoos, or Multi-Poos. As with all crossbreeds, it might be challenging to predict the size of a Maltipoo depending on which parent it takes after and whether it was crossed with a Miniature or Toy Poodle. Maltipoos are seldom if ever, crossed with a Standard Poodle.