Here’s my guide to the perfect 10 day road trip in Italy. This popular Italy road trip route takes you from the exciting city Milan in northern Italy to southern capital of Rome. This Italy road trip is dense with amazing must see medieval villages, ornate palazzos, Roman ruins, and treasures of the Renaissance. You'll discover some of the top attractions and best things to do and see in Italy, from Milan's Duomo to Rome's Colosseum. Read on for what to see and do from Milan to Rome!