Tamar Schlick

B.S., Wayne State Univeristy

Ph.D., New York University Courant Institute of Mathematical Sciences

Postdoctoral research, NYU and Weizmann Institute, Israel

Biomolecular modeling, multiscale modeling, computational and structural biophysics, genome organization, RNA structure and design, epigenetics and human disease, SARS-CoV-2 RNA structure and Covid-19 anti-viral therapy, Computational Biology and Mathematics Courses.

American Chemical Society
Associations American Association for the Advancement of Science
American Physical Society
American Association of Women in Science
Association for Women in Science
Association for Women in Mathematics
Biophysical Society
Society for Industrial and Applied Mathematics
Society for Mathematical Biology

T. SCHLICK and W.K. Olson, “Trefoil Knotting Revealed by Molecular Dynamics of Supercoiled DNA”, Science 257, 1110–1115. (1992)

T. SCHLICK, R. D. Skeel, A. T. Brunger, L. V. Kale, J. Hermans, K. Schulten, and J. A. Board, Jr., “Algorithmic Challenges in Computational Molecular Biophysics”, J. Chem. Phys. 151: 9-48. (1999)

H. H. Gan, S. Pasquali, and T. SCHLICK, “Exploring the Repertoire of RNA Secondary Motifs Using Graph Theory; Implications for RNA Design”, Nuc. Acids Res. 31, 2926–2943. (2003)

R. Radhakrishnan and T. SCHLICK, “Orchestration of Cooperative Events in DNA Synthesis and Repair Mechanism Unraveled by Transition Path Sampling of DNA Polymerase β’s Closing”, Proc. Natl. Acad. Sci. USA 101, 5970–5975. (2004)

S. Grigoryev, G. Arya, S. Correll, C. Woodcock, and T. SCHLICK, “Nucleosome Packing and Interactions in Higher-Order Chromatin Fibers”, Proc. Natl. Acad. Sci. USA 106: 13317–13322. (2009)

T. SCHLICK, Molecular Modeling: An Interdisciplinary Guide, Second Edition, Springer-Verlag, NY (801 pages). (2010)

R. Collepardo-Guevara, and T. SCHLICK, “Chromatin fiber polymorphism triggered by variations in linker lengths”, Proc. Natl. Acad. Sci. USA 111: 8861-8866. (2014)

N. Kim, C. Laing, S. Elmetwaly, S. Jung, J. Curuksu, and T. SCHLICK, “Graph-Based Sampling   Approach for Approximating Global Helical Topologies of RNA”, Proc. Natl. Acad. Sci. USA 111: 4079-4084. (2014)

D. Freudenthal, W. A. Beard, L. Perera, D. D. Shock, T. Kim, T. SCHLICK, and S. H. Wilson, "Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide”, Nature 517: 635-639. (2015)

R. Collepardo-Guevara, G. Portella, M. Vendruscolo, D. Frenkel, T. SCHLICK, and M. Orozco, “Chromatin Unfolding by Epigenetic Modifications Explained by Dramatic Impairment of Internucleosome Interactions: A Multiscale Computational Study”, J. Amer. Chem. Soc. 137: 10205-10215. (2015)

S. Grigoryev, G. Bascom, J. M. Buckwalter, M. Schubert, C. L. Woodcock, and T. SCHLICK, “Hierarchical Looping of Zigzag Nucleosome Chains in Metaphase Chromosomes”, Proc. Natl. Acad. Sci. USA 113: 1238-1243. (2016)

G. Bascom, C. Myers, and T. Schlick, “Mesoscale Modeling Reveals Formation of an Epigenetically Driven HOXC Gen Hub”, Proc. Natl. Acad. Sci. U.S.A., 116: 4955-4962 (2019)

T. Schlick et al. “Biomolecular Modeling and Simulation: A Prospering Multidisciplinary Field”, Annu. Rev. Biophys., 50:267-301 (2021)

T. Schlick and Portillo-Ledesma S., “Biomolecular Modeling Thrives in the Age of Technology”, Nature Comput. Sci. 1:321-331 (2021).

T. Schlick et al. “To Knot or Not to Knot: Multiple Conformations of the SARS-CoV-2 Frameshifting RNA Element”, J. Am. Chem. Soc., 143:11404-11422 (2021).

Book: Molecular Modeling and Simulation: An Interdisciplinary Guide, New York: Springer-Verlag, Second Edition (2010).  For more information about this book, click here.

For a detailed list of Professor Schlick Group's publications, click here.