Short Wave Plus

Dietary supplements — the vitamins, herbs and botanicals that you'll find in most grocery stores — are everywhere. More than half of U.S. adults over 20 take them, spending almost $50 billion on vitamins and other supplements in 2021. Yet decades of research have produced little evidence that they really work. Aaron Scott talks to Dr. Jenny Jia about the science of dietary supplements: which ones might help, which ones might hurt, and where we could be spending our money instead.

Brazil's president-elect, Luiz Inacio Lula da Silva, is renewing calls to protect the Amazon and reign in the deforestation. Climate scientists are encouraged but so far there aren't a lot of specifics of how this might happen. NPR's Kirk Siegler traveled to a remote Amazonian research station that is also threatened by illegal logging and talks to host Aaron Scott about his trip.

On Dec. 5 at 1 o'clock in the morning local time, researchers at the Lawrence Livermore National Laboratory in California used lasers to zap a tiny pellet of hydrogen fuel. The lasers hit their target with 2.05 megajoules of energy, and the pellet released roughly 3.15 megajoules. It's a major milestone, and one that the field of fusion science has struggled to reach for more than half a century: producing a fusion reaction that generates more energy than it consumes. While progress, the technology is still a ways off from its promise to produce energy without creating greenhouse gases. Today on the show, Regina G. Barber brings us two NPR stories that explain what this experiment showed and what else needs to happen to make fusion a practical energy source.

Gene editing was a new idea in the mid-1970s. So when Harvard and MIT planned new research in recombinant DNA, alarm bells went off. "People were worried about a 'Frankengene,'" says Lydia Villa-Komaroff, then a freshly minted PhD. Amidst a political circus, the city of Cambridge, Massachusetts banned research into recombinant DNA, forcing scientists like Villa-Komaroff into exile. But that turned out to be just the prelude to a breakthrough. In this episode, Dr. Villa-Komaroff tells Emily Kwong the story of overcoming the skeptics and coaxing bacteria into producing insulin for humans.

The human body is made up of more than 30 trillion cells, but how do they all work together? It's all about communication! "They talk through molecules going from one cell to the adjacent cell," says Dr. Sandra Murray, a professor of cell biology and physiology at the University of Pittsburgh who studies how cells communicate with each other to do complex tasks, like close a wound or deliver a baby. <br /><br />This year, Dr. Murray became the first person of color elected as president of the American Society for Cell Biology. She talks with host Aaron Scott about the beautiful language of cells, how she made her way as a Black woman in STEM, and what gives her hope in her field today.

When lightning strikes a giant tree in the tropical rainforest, there's usually no fire, no blackened crater — you might not even notice any damage. But come back months later, as Evan Gora does, and you may find that tree and dozens around it dead. Gora, a forest ecologist who studies lightning in tropical forests, says we are just beginning to understand how lightning actually behaves in these forests, and what its implications are for climate change. On today's episode, Evan Gora tells Aaron Scott about shocking discoveries in lightning research, and why Evan has developed a healthy respect for the hazards it poses – both to individual researchers and to the forests that life on Earth depends on.

In the mornings, Sonia Vallabh and Eric Minikel's first job is to get their two garrulous kids awake, fed and out the door to daycare and kindergarten. They then reconvene at the office and turn their focus to their all-consuming mission: to cure, treat, or prevent genetic prion disease. <br /><br />Prions are self-replicating proteins that can cause fatal brain disease. For a decade, Sonia Vallabh has been living with the knowledge that she has a genetic mutation that will likely cause in her the same disease that claimed her mother's life in 2010. Upon discovering she had the mutation, Sonia and her husband made a massive pivot: They went from careers in law and urban planning to earning their Ph.D.s, and founding a prion research lab at the Broad Institute of MIT and Harvard. On today's episode, Sonia and Eric talk with Short Wave's Gabriel Spitzer about what it's like to run a lab with one's spouse, cope with the ticking clock in Sonia's genes, and find hope in a bleak diagnosis.

In the mornings, Sonia Vallabh and Eric Minikel's first job is to get their two garrulous kids awake, fed and out the door to daycare and kindergarten. They then reconvene at the office and turn their focus to their all-consuming mission: to cure, treat, or prevent genetic prion disease. <br /><br />Prions are self-replicating proteins that can cause fatal brain disease. For a decade, Sonia Vallabh has been living with the knowledge that she has a genetic mutation that will likely cause in her the same disease that claimed her mother's life in 2010. Upon discovering she had the mutation, Sonia and her husband made a massive pivot: They went from careers in law and urban planning to earning their Ph.D.s, and founding a prion research lab at the Broad Institute of MIT and Harvard. On today's episode, Sonia and Eric talk with Short Wave's Gabriel Spitzer about what it's like to run a lab with one's spouse, cope with the ticking clock in Sonia's genes, and find hope in a bleak diagnosis.

The first time Sonia Vallabh understood something was very wrong with her mother Kamni was on the phone on her mom's 52nd birthday. She wasn't herself. By the end of that year, after about six months on life support, Kamni had died. <br /><br />The disease she died from would upend Sonia and her husband Eric's lives, and send them on a careening journey toward a completely new calling: to prevent or cure the disease that's stalking Sonia's family." Sonia Vallabh and Eric Minikel join Short Wave to tell their story in this second of three episodes on prion disease.

The first time Sonia Vallabh understood something was very wrong with her mother Kamni was on the phone on her mom's 52nd birthday. She wasn't herself. By the end of that year, after about six months on life support, Kamni had died. <br /><br />The disease she died from would upend Sonia and her husband Eric's lives, and send them on a careening journey toward a completely new calling: to prevent or cure the disease that's stalking Sonia's family." Sonia Vallabh and Eric Minikel join Short Wave to tell their story in this second of three episodes on prion disease.

Prions are biological anomalies – self-replicating, not-alive little particles that can misfold into an unstoppable juggernaut of fatal disease. Prions don't contain genes, and yet they make more of themselves. That has forced scientists to rethink the "central dogma" of molecular biology: that biological information is always passed on through genes. The journey to discovering, describing, and ultimately understanding how prions work began with a medical mystery in a remote part of New Guinea in the 1950s. The indigenous Fore people were experiencing a horrific epidemic of rapid brain-wasting disease. The illness was claiming otherwise healthy people, often taking their lives within months of diagnosis. Solving the puzzle would help unlock one of the more remarkable discoveries in late-20th-century medicine, and introduce the world to a rare but potent new kind of pathogen. For the first episode in a series of three about prion disease, Short Wave's Gabriel Spitzer shares the science behind these proteins with Emily Kwong, and explains why prions keep him awake at night.

Prions are biological anomalies – self-replicating, not-alive little particles that can misfold into an unstoppable juggernaut of fatal disease. Prions don't contain genes, and yet they make more of themselves. That has forced scientists to rethink the "central dogma" of molecular biology: that biological information is always passed on through genes. The journey to discovering, describing, and ultimately understanding how prions work began with a medical mystery in a remote part of New Guinea in the 1950s. The indigenous Fore people were experiencing a horrific epidemic of rapid brain-wasting disease. The illness was claiming otherwise healthy people, often taking their lives within months of diagnosis. Solving the puzzle would help unlock one of the more remarkable discoveries in late-20th-century medicine, and introduce the world to a rare but potent new kind of pathogen. For the first episode in a series of three about prion disease, Short Wave's Gabriel Spitzer shares the science behind these proteins with Emily Kwong, and explains why prions keep him awake at night.

Today, we pass the mic to our colleagues at <em>All Things Considered</em> to share the first piece in their series on the impact of climate change, global migration and far-right politics. They begin with the story of Mamadou Thiam, a Senegalese man living in a temporary shelter created by the United Nations. He is from a family of fishermen, but floods have destroyed his home. In the past when there was flooding, people could relocate for a few months and then return. But more flooding means leaving may become permanent.

Today, we pass the mic to our colleagues at <em>All Things Considered</em> to share the first piece in their series on the impact of climate change, global migration and far-right politics. They begin with the story of Mamadou Thiam, a Senegalese man living in a temporary shelter created by the United Nations. He is from a family of fishermen, but floods have destroyed his home. In the past when there was flooding, people could relocate for a few months and then return. But more flooding means leaving may become permanent.

Regina G. Barber talks with Dr. Rosalyn LaPier about ethnobotany--what it is and how traditional plant knowledge is frequently misunderstood in the era of COVID and psychedelics. And, how it's relevant and important for reproductive health today.

Regina G. Barber talks with Dr. Rosalyn LaPier about ethnobotany--what it is and how traditional plant knowledge is frequently misunderstood in the era of COVID and psychedelics. And, how it's relevant and important for reproductive health today.

Correspondent Allison Aubrey talks to host Emily Kwong about the pros and cons of adopting permanent Daylight Saving Time or year-round Standard Time.

Correspondent Allison Aubrey talks to host Emily Kwong about the pros and cons of adopting permanent Daylight Saving Time or year-round Standard Time.