Brief Report: Autism Symptoms in Infants with Fragile X Syndrome
- PMID: 27628938
- PMCID: PMC5112110
- DOI: 10.1007/s10803-016-2903-5
Brief Report: Autism Symptoms in Infants with Fragile X Syndrome
Abstract
Fragile X syndrome (FXS) is the most common known genetic cause of autism spectrum disorder (ASD). Although 50-75 % of children with FXS meet ASD criteria, no studies have compared ASD symptoms in infants with FXS versus other high risk groups, such as siblings of children with ASD (ASIBs). Using the Autism Observation Scale for Infants, our findings indicate that 53 % of 12-month infants with FXS fall in the "at risk" category compared to 17 and 6 % for age-matched ASIBs and controls, respectively. Elevated atypical motor behaviors were associated with elevated risk for FXS. Cross-syndrome comparisons are essential to understanding the heterogeneity of ASD and identifying candidate markers that will facilitate differential diagnosis of ASD in genetic disorders such as FXS.
Keywords: Autism; Autism Observation Scale for Infants; Fragile X; Infants.
Figures
Similar articles
-
Gesture Frequency and Function in Infants With Fragile X Syndrome and Infant Siblings of Children With Autism Spectrum Disorder.J Speech Lang Hear Res. 2019 Jul 15;62(7):2386-2399. doi: 10.1044/2019_JSLHR-L-17-0491. Epub 2019 Jun 27. J Speech Lang Hear Res. 2019. PMID: 31251678 Free PMC article.
-
Early social communication in infants with fragile X syndrome and infant siblings of children with autism spectrum disorder.Res Dev Disabil. 2017 Dec;71:169-180. doi: 10.1016/j.ridd.2017.10.004. Epub 2017 Oct 15. Res Dev Disabil. 2017. PMID: 29040924 Free PMC article.
-
Melatonin as a Novel Interventional Candidate for Fragile X Syndrome with Autism Spectrum Disorder in Humans.Int J Mol Sci. 2017 Jun 20;18(6):1314. doi: 10.3390/ijms18061314. Int J Mol Sci. 2017. PMID: 28632163 Free PMC article. Review.
-
Autism Symptoms in Fragile X Syndrome.J Child Neurol. 2017 Sep;32(10):903-909. doi: 10.1177/0883073817712875. Epub 2017 Jun 15. J Child Neurol. 2017. PMID: 28617074 Review.
-
Autism Spectrum Disorder Symptoms in Infants with Fragile X Syndrome: A Prospective Case Series.J Autism Dev Disord. 2017 Jun;47(6):1628-1644. doi: 10.1007/s10803-017-3081-9. J Autism Dev Disord. 2017. PMID: 28281129 Free PMC article.
Cited by
-
Negative affect and respiratory sinus arrhythmia are differentially related to social anxiety and autism features in autistic preschoolers contrasted to fragile X syndrome.Front Psychiatry. 2023 Mar 20;14:1151263. doi: 10.3389/fpsyt.2023.1151263. eCollection 2023. Front Psychiatry. 2023. PMID: 37020738 Free PMC article.
-
Early communication development in infants and toddlers with Fragile X syndrome.Autism Dev Lang Impair. 2022 May 6;7:23969415221099403. doi: 10.1177/23969415221099403. eCollection 2022 Jan-Dec. Autism Dev Lang Impair. 2022. PMID: 36438157 Free PMC article.
-
[Towards an early differential diagnosis in autism spectrum disorders and fragile X syndrome. A systematic review].Rev Neurol. 2022 Oct 16;75(8):213-223. doi: 10.33588/rn.7508.2022074. Rev Neurol. 2022. PMID: 36218252 Free PMC article. Spanish.
-
Subcortical Brain Development in Autism and Fragile X Syndrome: Evidence for Dynamic, Age- and Disorder-Specific Trajectories in Infancy.Am J Psychiatry. 2022 Aug;179(8):562-572. doi: 10.1176/appi.ajp.21090896. Epub 2022 Mar 25. Am J Psychiatry. 2022. PMID: 35331012 Free PMC article.
-
Neural Correlates of Infant Face Processing and Later Emerging Autism Symptoms in Fragile X Syndrome.Front Psychiatry. 2021 Nov 24;12:716642. doi: 10.3389/fpsyt.2021.716642. eCollection 2021. Front Psychiatry. 2021. PMID: 34899412 Free PMC article.
References
-
- Brian J, Zwaigenbaum L, Bryson SE, Roberts W, Smith IM, Szatmari P, et al. Behavioral markers predictive of ASD in high risk infants at 6 months. Presentation at IMFAR, San Sebastian. 2013:2013.
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical