Neuroimaging endophenotypes: strategies for finding genes influencing brain structure and function
- PMID: 17440953
- PMCID: PMC6871286
- DOI: 10.1002/hbm.20401
Neuroimaging endophenotypes: strategies for finding genes influencing brain structure and function
Abstract
It is vitally important to identify the genetic determinants of complex brain-related disorders such as autism, dementia, mood disorders, and schizophrenia. However, the search for genes predisposing individuals to these illnesses has been hampered by their genetic and phenotypic complexity and by reliance upon phenomenologically based qualitative diagnostic systems. Neuroimaging endophenotypes are quantitative indicators of brain structure or function that index genetic liability for an illness. These indices will significantly improve gene discovery and help us to understand the functional consequences of specific genes at the level of systems neuroscience. Here, we review the feasibility of using neuroanatomic and neuropsychological measures as endophenotypes for brain-related disorders. Specifically, we examine specific indices of brain structure or function that are genetically influenced and associated with neurological and psychiatric illness. In addition, we review genetic approaches that capitalize on the use of quantitative traits, including those derived from brain images.
(c) 2007 Wiley-Liss, Inc.
Figures
![Figure 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/6871286/bin/HBM-28-488-g001.gif)
![Figure 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/6871286/bin/HBM-28-488-g002.gif)
Similar articles
-
A review of endophenotypes in schizophrenia and autism: The next phase for understanding genetic etiologies.Am J Med Genet C Semin Med Genet. 2017 Sep;175(3):354-361. doi: 10.1002/ajmg.c.31566. Epub 2017 Jun 29. Am J Med Genet C Semin Med Genet. 2017. PMID: 28661580 Review.
-
Arguments for the sake of endophenotypes: examining common misconceptions about the use of endophenotypes in psychiatric genetics.Am J Med Genet B Neuropsychiatr Genet. 2014 Mar;165B(2):122-30. doi: 10.1002/ajmg.b.32221. Epub 2014 Jan 24. Am J Med Genet B Neuropsychiatr Genet. 2014. PMID: 24464604 Free PMC article. Review.
-
High dimensional endophenotype ranking in the search for major depression risk genes.Biol Psychiatry. 2012 Jan 1;71(1):6-14. doi: 10.1016/j.biopsych.2011.08.022. Epub 2011 Oct 7. Biol Psychiatry. 2012. PMID: 21982424 Free PMC article.
-
Discovering imaging endophenotypes for major depression.Mol Psychiatry. 2011 Jun;16(6):604-19. doi: 10.1038/mp.2011.23. Mol Psychiatry. 2011. PMID: 21602829 Review.
-
Cortical mapping of genotype-phenotype relationships in schizophrenia.Hum Brain Mapp. 2007 Jun;28(6):519-32. doi: 10.1002/hbm.20404. Hum Brain Mapp. 2007. PMID: 17437284 Free PMC article. Review.
Cited by
-
Neuroanatomical Predictors of Transcranial Direct Current Stimulation (tDCS)-Induced Modifications in Neurocognitive Task Performance in Typically Developing Individuals.J Neurosci. 2024 May 29;44(22):e1372232024. doi: 10.1523/JNEUROSCI.1372-23.2024. J Neurosci. 2024. PMID: 38548336
-
Genome- and Exome-Wide Association Studies Revealed Candidate Genes Associated with DaTscan Imaging Features.Parkinsons Dis. 2023 Aug 23;2023:2893662. doi: 10.1155/2023/2893662. eCollection 2023. Parkinsons Dis. 2023. PMID: 37664790 Free PMC article.
-
Telomere length and brain imaging phenotypes in UK Biobank.PLoS One. 2023 Mar 22;18(3):e0282363. doi: 10.1371/journal.pone.0282363. eCollection 2023. PLoS One. 2023. PMID: 36947528 Free PMC article.
-
Structural Relationship between Cerebral Gray and White Matter Alterations in Degenerative Cervical Myelopathy.Tomography. 2023 Jan 31;9(1):315-327. doi: 10.3390/tomography9010025. Tomography. 2023. PMID: 36828377 Free PMC article.
-
A cross-cohort replicable and heritable latent dimension linking behaviour to multi-featured brain structure.Commun Biol. 2022 Nov 26;5(1):1297. doi: 10.1038/s42003-022-04244-5. Commun Biol. 2022. PMID: 36435870 Free PMC article.
References
-
- Ashburner J, Csernansky JG, Davatzikos C, Fox NC, Frisoni GB, Thompson PM ( 2003): Computer‐assisted imaging to assess brain structure in healthy and diseased brains. Lancet Neurol 2: 79–88. - PubMed
-
- Atwood LD, Wolf PA, Heard‐Costa NL, Massaro JM, Beiser A, D'Agostino RB, DeCarli C ( 2004): Genetic variation in white matter hyperintensity volume in the Framingham Study. Stroke 35: 1609–1613. - PubMed
-
- Baare WF, Hulshoff Pol HE, Boomsma DI, Posthuma D, de Geus EJ, Schnack HG, van Haren NE, van Oel CJ, Kahn RS ( 2001): Quantitative genetic modeling of variation in human brain morphology. Cereb Cortex 11: 816–824. - PubMed
-
- Bartley AJ, Jones DW, Weinberger DR ( 1997): Genetic variability of human brain size and cortical gyral patterns. Brain 120 (Part 2): 257–269. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical