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Acute paediatrics
Acute ataxia complicating Langherans cell histiocytosis
  1. A Polizzi1,
  2. S Coghill2,
  3. M A McShane3,
  4. W Squier4
  1. 1Department of Paediatrics, University of Catania, Italy
  2. 2Department of Cellular Pathology, The General Hospital, Northampton, UK
  3. 3Department of Paediatrics, John Radcliffe Hospital, Oxford, UK
  4. 4Neuropathology Department, The Radcliffe Infirmary NHS Trust, Oxford, UK
  1. Correspondence to:
    Dr A Polizzi, Department of Paediatrics, University of Catania, Via S. Sofia, 78, I-95123 Catania, Italy;
    rupo{at}ctonline.it

Abstract

A case is reported of a 3 year old boy with an acute history of cerebellar impairment and x ray evidence of apparent chest infection. At postmortem examination, his lungs but not the nervous system were found to be massively infiltrated by Langherans histiocytes. In retrospect, the acute ataxia was diagnosed as a paraneoplastic phenomenon secondary to Langherans cell histiocytosis (LCH). This represents a unique occurrence complicating LCH in childhood.

  • acute ataxia
  • Langherans cell histiocytosis
  • paraneoplastic syndrome
  • CNS, central nervous system
  • LCH, Langherans cell histiocytosis

https://doi.org/10.1136/adc.86.2.130

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