Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials
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Welcome to the Living Textbook of pragmatic clinical trials, a collection of knowledge from the NIH Pragmatic Trials Collaboratory. Pragmatic clinical trials present an opportunity to efficiently generate high-quality evidence to inform medical decision-making. However, these trials pose different challenges than traditional clinical trials. The Living Textbook reflects a collection of special considerations and best practices in the design, conduct, and reporting of pragmatic clinical trials.
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What is the
NIH Pragmatic Trials Collaboratory?
What is a
pragmatic clinical trial?
Training Resources
Featured
Free Virtual Workshop July 15-16 to Feature NIH Director as Keynote
“Going From Zero to 100: Generating Evidence Through Pragmatic Research to Address Pressing Healthcare Issues” will examine actions researchers can take during planning and application development to create efficient, large-scale pragmatic clinical trials that generate actionable evidence. The workshop will feature a keynote presentation from NIH Director Dr. Monica Bertagnolli. Register today!
NIH Pragmatic Trials Collaboratory Launches New Online Training Resources
Check out the new training resources page, featuring a video library, learning modules, and workshop archives. Take a tour of the enhanced training resources webpages we built to help researchers learn about pragmatic trials.
NIH COLLABORATORY TRIALS
Pragmatic clinical trials that address questions of major public health importance and provide proof of concept for innovative pragmatic research designs.
CORES
Working groups that support the conduct of NIH Collaboratory Trials and generate guidance addressing implementation challenges.
DISTRIBUTED RESEARCH NETWORK
Network enabling investigators to collaborate in the use of electronic health data while safeguarding protected health information.
Upcoming Learning Opportunities
Grand Rounds July 26, 2024: Interventions for Optimization of Guideline-Directed Medical Therapy (Gregg C. Fonarow, MD)
July 26 @ 1:00 pm - 2:00 pmGrand Rounds August 9, 2024: Does Starting Buprenorphine Prevent Suicidal Behavior: What Trial Should We Emulate? (Gregory Simon, MD, MPH; Susan Shortreed PhD)
August 9 @ 1:00 pm - 2:00 pm
NEWS
- July 18, 2024: Latest Podcast Features Pearl O’Rourke and Stephanie Morain on Waiver of ConsentIn a new episode of our Rethinking Clinical Trials podcast, Drs. Pearl O’Rourke and Stephanie Morain speak with host Dr. Adrian Hernandez about waiver or alteration of informed consent for ...
- July 17, 2024: In This Week’s PCT Grand Rounds, Lessons From the PRECIDENTD Comparative Effectiveness TrialIn this Friday’s PCT Grand Rounds, Brendan Everett and Deborah Wexler of Harvard Medical School will present “Lessons From PRECIDENTD: A Pragmatic Comparative Effectiveness Trial.” The Grand Rounds session will be ...
- July 16, 2024: OS-PCORTF Report Focuses on Building Data Capacity for Patient-Centered Outcomes ResearchA recent report from the Assistant Secretary for Planning and Evaluation in the US Department of Health and Human Services outlines 36 projects funded by the Office of the Secretary ...