Prostate cancer: relative effects of demographic, clinical, histologic, and MR imaging variables on the accuracy of staging
- PMID: 9240538
- DOI: 10.1148/radiology.204.2.9240538
Prostate cancer: relative effects of demographic, clinical, histologic, and MR imaging variables on the accuracy of staging
Abstract
Purpose: To determine the effects on the accuracy of staging prostate gland cancer of diagnostic prediction rules based on demographic, clinical, histologic, and magnetic resonance (MR) image variables.
Materials and methods: A total of 200 cases from four medical centers were evaluated by nine radiologists experienced in MR imaging. The accuracies of the four diagnostic variables (age, prostate specific antigen level, Gleason tumor grade, and MR imaging findings) were measured, both singly and combined in a particular sequence, by calculating the area index of the receiver operating characteristic curve.
Results: The accuracy of staging with single variables (age, 0.58; prostate specific antigen level, 0.74; Gleason grade 0.73, MR image findings, 0.74) increased as the variables were optimally merged. The first two variables combined to yield an accuracy of 0.74; the first three combined to yield an accuracy of 0.81; and all four variables resulted in an accuracy of 0.86. In a clinically important subset of 69 cases for which antigen level and Gleason grade together were inconclusive for the purposes of staging, the addition of MR imaging findings resulted in an increase in accuracy from 0.55 to 0.73.
Conclusion: Optimal merging of diagnostic test results yields an improvement in the accuracy of prostate cancer staging.
Similar articles
-
Preoperative neural network using combined magnetic resonance imaging variables, prostate-specific antigen, and Gleason score to predict positive surgical margins.Urology. 2004 Sep;64(3):516-21. doi: 10.1016/j.urology.2004.04.027. Urology. 2004. PMID: 15351582
-
Usefulness of prebiopsy multifunctional and morphologic MRI combined with free-to-total prostate-specific antigen ratio in the detection of prostate cancer.AJR Am J Roentgenol. 2011 Jun;196(6):W715-22. doi: 10.2214/AJR.10.5700. AJR Am J Roentgenol. 2011. PMID: 21606259
-
[Staging of prostate cancer: value of the combined information of endorectal MRI, biopsy Gleason score, and preoperative PSA level].Rofo. 2006 Apr;178(4):385-90. doi: 10.1055/s-2006-926475. Rofo. 2006. PMID: 16607587 German.
-
Prostate cancer: incremental value of endorectal MR imaging findings for prediction of extracapsular extension.Radiology. 2004 Jul;232(1):133-9. doi: 10.1148/radiol.2321031086. Epub 2004 May 27. Radiology. 2004. PMID: 15166321
-
Multiparametric magnetic resonance imaging of the prostate.Magn Reson Imaging Clin N Am. 2013 May;21(2):409-26. doi: 10.1016/j.mric.2013.01.004. Epub 2013 Feb 16. Magn Reson Imaging Clin N Am. 2013. PMID: 23642560 Review.
Cited by
-
MR-guided prostate interventions.J Magn Reson Imaging. 2008 Feb;27(2):356-67. doi: 10.1002/jmri.21259. J Magn Reson Imaging. 2008. PMID: 18219689 Free PMC article. Review.
-
Prostate cancer: serum and tissue markers.Rev Urol. 2001;3 Suppl 2(Suppl 2):S11-9. Rev Urol. 2001. PMID: 16985995 Free PMC article.
-
Assessment of multiple sclerosis lesions with spherical harmonics: comparison of MR imaging and pathologic findings.Radiology. 2005 Jun;235(3):1036-44. doi: 10.1148/radiol.2353032071. Epub 2005 Apr 15. Radiology. 2005. PMID: 15833980 Free PMC article.
-
Three-dimensional magnetic resonance spectroscopic imaging of brain and prostate cancer.Neoplasia. 2000 Jan-Apr;2(1-2):166-89. doi: 10.1038/sj.neo.7900081. Neoplasia. 2000. PMID: 10933075 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
