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. 2022 Jul 20;22(1):128.
doi: 10.1186/s12880-022-00857-8.

Investigation of the relationship of CO-RADS and CT patterns with laboratory parameters in COVID-19 patients and a new perspective on the total CT scoring system

Nevin Aydin  1 , Pinar Yildiz  2 , Döndü Üsküdar Cansu  2 , Elif Gündogdu  3 , Rüya Mutluay  2 , Göknur Yorulmaz  2 , Melisa Sahin Tekin  2 , Evin Kocaturk  4 , I Özkan Alatas  4 , Elif Doyuk Kartal  5 , Nurettin Erben  5 , Gül Durmaz  6 , Nilgun Kasifoglu  6 , Tercan Us  6 , Garip Sahin  2 , Cengiz Bal  7 , Senay Yilmaz  8 , Cengiz Korkmaz  2
Affiliations

Investigation of the relationship of CO-RADS and CT patterns with laboratory parameters in COVID-19 patients and a new perspective on the total CT scoring system

Nevin Aydin et al. BMC Med Imaging. .

Abstract

Background: It is important to determine the correlation of the CO-RADS classification and computed tomography (CT) patterns of the lung with laboratory data. To investigate the relationship of CO-RADS categories and CT patterns with laboratory data in patients with a positive RT-PCR test. We also developed a structured total CT scoring system and investigated its correlation with the total CT scoring system.

Method: The CT examinations of the patients were evaluated in terms of the CO-RADS classification, pattern groups and total CT score. Structured total CT score values were obtained by including the total CT score values and pattern values in a regression analysis. The CT data were compared according to the laboratory data.

Results: A total of 198 patients were evaluated. There were significant differences between the CO-RADS groups in terms of age, ICU transfer, oxygen saturation, creatinine, LDH, D-dimer, high-sensitivity cardiac troponin-T (hs-TnT), CRP, structured total CT score values, and total CT score values. A significant difference was also observed between the CT pattern groups and oxygen saturation, creatinine and CRP values. When the structured total CT score values and total CT score values were compared they were observed to be correlated.

Conclusions: Creatinine can be considered as an important marker for the CO-RADS and pattern classifications in lung involvement. LDH can be considered as an important marker of parenchymal involvement, especially bilateral and diffuse involvement. The structured total CT scoring system is a new system that can be used as an alternative.

Keywords: CO-RADS; COVID-19; CT; CT pattern; HRCT; Total CT score.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Flow chart of the patient population
Fig. 2
Fig. 2
65 years old male patient. According to the CO-RADS category in terms of Covid pneumonia, a CO-RADS 5 patient had a mixed parenchyma pattern (pattern 2), and the patient's total CT score value was 11 and the structured total CT score value was 22 according to a, b and c
Fig. 3
Fig. 3
48 years old female patient. According to the CO-RADS category in terms of Covid pneumonia, a CO-RADS 4 patient had a mixed parenchyma pattern (pattern 2) with a peripheral lesion (white arrow), and the patient's total CT score value was 2 and the structured total CT score value was 4 according to HRCT scan
Fig. 4
Fig. 4
56 years old female patient. According to the CO-RADS category in terms of Covid pneumonia, a CO-RADS 3 patient had a ground glass parenchyma pattern (pattern 1) with a central lesion (white arrow), and the patient's total CT score value was 1 and the structured total CT score value was 1 according to HRCT scan
See this image and copyright information in PMC

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References

    1. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. doi: 10.1016/S0140-6736(20)30183-5. - DOI - PMC - PubMed
    1. Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, Ren R, Leung KSM, Lau EHY, Wong JY, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med. 2020;382(13):1199–1207. doi: 10.1056/NEJMoa2001316. - DOI - PMC - PubMed
    1. Shen ZY, Yan XC, You XD, Zhang XW. CT imaging research progress in 2019 novel coronavirus pneumonia. Curr Med Imaging. 2021;18(3):267–274. doi: 10.2174/1573405617666210816091217. - DOI - PMC - PubMed
    1. Long C, Xu H, Shen Q, Zhang X, Fan B, Wang C, Zeng B, Li Z, Li X, Li H. Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT? Eur J Radiol. 2020;126:108961. doi: 10.1016/j.ejrad.2020.108961. - DOI - PMC - PubMed
    1. Prokop M, van Everdingen W, van Rees Vellinga T, Quarles van Ufford H, Stöger L, Beenen L, Geurts B, Gietema H, Krdzalic J, Schaefer-Prokop C, et al. CO-RADS: a categorical CT assessment scheme for patients suspected of having COVID-19-definition and evaluation. Radiology. 2020;296(2):E97–104. 10.1148/radiol.2020201473 - PMC - PubMed