The Hole-Board Test in Mutant Mice
- PMID: 35482162
- DOI: 10.1007/s10519-022-10102-1
The Hole-Board Test in Mutant Mice
Abstract
First described by Boissier and Simon in (Ther Recreat J 17:1225-1232, 1962), the hole-board has become a recognized test of anxiety and spatial memory. Benzodiazepines acting at the GABAA-BZD site increase hole-pokes in rats and mice, indicating a loss in behavioral inhibition concordant with the behavior of mutant mice deficient in the GABA transporter. Hole-poking also depends on arousal mechanisms dependent on dopaminergic transmission, as indicated by drug and null mutant studies. In addition, the behavior is modified in natural and null mutants affecting the cerebellum as well as null mutants affecting neuropeptides, growth factors, cell adhesion, and inflammation. Further research is required to determine convergences between genetic and pharmacological effects.
Keywords: Behavioral inhibition; Benzodiazepines; Cerebellum; GABA; Hippocampus; Mouse exploration; Perseveration; Spatial memory.
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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References
-
- Adamec RE (1990) Amygdala kindling and anxiety in the rat. NeuroReport 1(3–4):255–258. https://doi.org/10.1097/00001756-199011000-00022 (PMID: 2129887) - DOI - PubMed
-
- Adamec RE, McKay D (1993) The effects of CRF and alpha-helical CRF on anxiety in normal and hypophysectomized rats. J Psychopharmacol 7(4):346–354. https://doi.org/10.1177/026988119300700406 (PMID: 22290998) - DOI - PubMed
-
- Anlar B, Gunel-Ozcan A (2012) Tenascin-R: role in the central nervous system. Int J Biochem Cell Biol 44(9):1385–1389. https://doi.org/10.1016/j.biocel.2012.05.009 (PMID: 22634605) - DOI - PubMed
-
- Armario A, Hernández J, Bluethmann H, Hidalgo J (1998) IL-6 deficiency leads to increased emotionality in mice: evidence in transgenic mice carrying a null mutation for IL-6. J Neuroimmunol 92(1–2):160–169. https://doi.org/10.1016/s0165-5728(98)00199-4 (PMID: 9916891) - DOI - PubMed
-
- Backman SA, Stambolic V, Suzuki A, Haight J, Elia A, Pretorius J, Tsao MS, Shannon P, Bolon B, Ivy GO, Mak TW (2001) Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat Genet 29(4):396–403. https://doi.org/10.1038/ng782 (PMID: 11726926) - DOI - PubMed
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