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Review
. 2021 Oct;43(5):2149-2160.
doi: 10.1007/s11357-021-00414-1. Epub 2021 Jul 25.

University of Alabama at Birmingham Nathan Shock Center: comparative energetics of aging

Steven N Austad  1 , Thomas W Buford  2 , David B Allison  3 , Scott W Ballinger  4 , Andrew W Brown  5 , Christy S Carter  2 , Victor M Darley-Usmar  4 , John L Hartman  6 , Timothy R Nagy  7 , Daniel L Smith Jr  7 , Liou Sun  8 , Jianhua Zhang  4
Affiliations
Review

University of Alabama at Birmingham Nathan Shock Center: comparative energetics of aging

Steven N Austad et al. Geroscience. 2021 Oct.

Abstract

The UAB Nathan Shock Center focuses on comparative energetics and aging. Energetics, as defined for this purpose, encompasses the causes, mechanisms, and consequences of the acquisition, storage, and use of metabolizable energy. Comparative energetics is the study of metabolic processes at multiple scales and across multiple species as it relates to health and aging. The link between energetics and aging is increasingly understood in terms of dysregulated mitochondrial function, altered metabolic signaling, and aberrant nutrient responsiveness with increasing age. The center offers world-class expertise in comprehensive, integrated energetic assessment and analysis from the level of the organelle to the organism and across species from the size of worms to rats as well as state-of-the-art data analytics. The range of services offered by our three research cores, (1) The Organismal Energetics Core, (2) Mitometabolism Core, and (3) Data Analytics Core, is described herein.

Keywords: Aging; Analytics; Bioenergetics; Comparative biology; Energetics; Metabolism; Mitochondria.

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