Thirst-associated preoptic neurons encode an aversive motivational drive
- PMID: 28912243
- PMCID: PMC5723384
- DOI: 10.1126/science.aan6747
Thirst-associated preoptic neurons encode an aversive motivational drive
Abstract
Water deprivation produces a drive to seek and consume water. How neural activity creates this motivation remains poorly understood. We used activity-dependent genetic labeling to characterize neurons activated by water deprivation in the hypothalamic median preoptic nucleus (MnPO). Single-cell transcriptional profiling revealed that dehydration-activated MnPO neurons consist of a single excitatory cell type. After optogenetic activation of these neurons, mice drank water and performed an operant lever-pressing task for water reward with rates that scaled with stimulation frequency. This stimulation was aversive, and instrumentally pausing stimulation could reinforce lever-pressing. Activity of these neurons gradually decreased over the course of an operant session. Thus, the activity of dehydration-activated MnPO neurons establishes a scalable, persistent, and aversive internal state that dynamically controls thirst-motivated behavior.
Copyright © 2017, American Association for the Advancement of Science.
Figures
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Comment in
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Neurons that drive and quench thirst.Science. 2017 Sep 15;357(6356):1092-1093. doi: 10.1126/science.aao5574. Science. 2017. PMID: 28912228 No abstract available.
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