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. 2017 Aug:93:85-86.
doi: 10.1016/j.jcv.2017.02.005. Epub 2017 Feb 15.

Diagnosing acute HIV infection: The performance of quantitative HIV-1 RNA testing (viral load) in the 2014 laboratory testing algorithm

Hsiu Wu  1 , Stephanie E Cohen  2 , Emily Westheimer  3 , Cynthia L Gay  4 , Laura Hall  5 , Charles Rose  6 , Lisa B Hightow-Weidman  4 , Severin Gose  2 , Jie Fu  3 , Philip J Peters  7
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Diagnosing acute HIV infection: The performance of quantitative HIV-1 RNA testing (viral load) in the 2014 laboratory testing algorithm

Hsiu Wu et al. J Clin Virol. 2017 Aug.

Abstract

New recommendations for laboratory diagnosis of HIV infection in the United States were published in 2014. The updated testing algorithm includes a qualitative HIV-1 RNA assay to resolve discordant immunoassay results and to identify acute HIV-1 infection (AHI). The qualitative HIV-1 RNA assay is not widely available; therefore, we evaluated the performance of a more widely available quantitative HIV-1 RNA assay, viral load, for diagnosing AHI. We determined that quantitative viral loads consistently distinguished AHI from a false-positive immunoassay result. Among 100 study participants with AHI and a viral load result, the estimated geometric mean viral load was 1,377,793copies/mL.

Keywords: Acute HIV infection; Fourth-generation immunoassay; HIV diagnosis; HIV testing; Quantitative HIV-1 viral load.

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