Fasting of mice: a review
- PMID: 24025567
- DOI: 10.1177/0023677213501659
Fasting of mice: a review
Abstract
Fasting of mice is a common procedure performed in association with many different types of experiments mainly in order to reduce variability in investigatory parameters or to facilitate surgical procedures. However, the effects of fasting not directly related to the investigatory parameters are often ignored. The aim of this review is to present and summarize knowledge about the effects of fasting of mice to facilitate optimization of the fasting procedure for any given study and thereby maximize the scientific outcome and minimize the discomfort for the mice and hence ensure high animal welfare. The results are presented from a number of experimental studies, providing evidence for fasting-induced changes in hormone balance, body weight, metabolism, hepatic enzymes, cardiovascular parameters, body temperature and toxicological responses. A description of relevant normal behaviour and standard physiological parameters is given, concluding that mice are primarily nocturnal and consume two-thirds of their total food intake during the night. It is argued that overnight fasting of mice is not comparable with overnight fasting of humans because the mouse has a nocturnal circadian rhythm and a higher metabolic rate. It is suggested that because many physiological parameters are regulated by circadian rhythms, fasting initiated at different points in the circadian rhythm has different impacts and produces different results.
Keywords: fasting; mice; nutrition; refinement; torpor.
Similar articles
-
Multiple effects of circadian dysfunction induced by photoperiod shifts: alterations in context memory and food metabolism in the same subjects.Physiol Behav. 2013 Jun 13;118:14-24. doi: 10.1016/j.physbeh.2013.04.010. Epub 2013 May 7. Physiol Behav. 2013. PMID: 23660277
-
Circadian variation in heart rate, blood pressure, body temperature and EEG of immature broiler breeder chickens in restricted-fed and ad libitum-fed states.Br Poult Sci. 2006 Oct;47(5):599-606. doi: 10.1080/00071660600939719. Br Poult Sci. 2006. PMID: 17050105 Clinical Trial.
-
Food or fluid restriction in common laboratory animals: balancing welfare considerations with scientific inquiry.Comp Med. 2007 Apr;57(2):149-60. Comp Med. 2007. PMID: 17536615 Review.
-
Diurnal variation in circulating leptin is dependent on gender, food intake and circulating insulin in mice.Acta Physiol Scand. 2000 Aug;169(4):325-31. doi: 10.1046/j.1365-201x.2000.00746.x. Acta Physiol Scand. 2000. PMID: 10951124
-
Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.Food Chem Toxicol. 2008 Mar;46 Suppl 1:S2-70. doi: 10.1016/j.fct.2008.02.008. Epub 2008 Feb 13. Food Chem Toxicol. 2008. PMID: 18328408 Review.
Cited by
-
Characterization of a Syngeneic Orthotopic Model of Cholangiocarcinoma by [18F]FDG-PET/MRI.Cancers (Basel). 2024 Jul 19;16(14):2591. doi: 10.3390/cancers16142591. Cancers (Basel). 2024. PMID: 39061229 Free PMC article.
-
Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease.Sci Adv. 2024 May 17;10(20):eadj5942. doi: 10.1126/sciadv.adj5942. Epub 2024 May 17. Sci Adv. 2024. PMID: 38758779 Free PMC article.
-
Hippocampal neuroimmune response in mice undergoing serial daily torpor induced by calorie restriction.Front Neuroanat. 2024 Apr 15;18:1334206. doi: 10.3389/fnana.2024.1334206. eCollection 2024. Front Neuroanat. 2024. PMID: 38686173 Free PMC article.
-
Time of day and circadian disruption influence host response and parasite growth in a mouse model of cerebral malaria.iScience. 2024 Apr 8;27(5):109684. doi: 10.1016/j.isci.2024.109684. eCollection 2024 May 17. iScience. 2024. PMID: 38680656 Free PMC article.
-
Metabolic programming of organ-specific natural killer cell responses.Immunol Rev. 2024 May;323(1):8-18. doi: 10.1111/imr.13333. Epub 2024 Apr 17. Immunol Rev. 2024. PMID: 38628147 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources