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Review
. 2010 Apr;15(2):109-24.
doi: 10.1111/j.1369-1600.2009.00192.x.

Ethanol consumption: how should we measure it? Achieving consilience between human and animal phenotypes

Robert F Leeman  1 , Markus Heilig, Christopher L Cunningham, David N Stephens, Theodora Duka, Stephanie S O'Malley
Affiliations
Review

Ethanol consumption: how should we measure it? Achieving consilience between human and animal phenotypes

Robert F Leeman et al. Addict Biol. 2010 Apr.

Abstract

There is only modest overlap in the most common alcohol consumption phenotypes measured in animal studies and those typically studied in humans. To address this issue, we identified a number of alcohol consumption phenotypes of importance to the field that have potential for consilience between human and animal models. These phenotypes can be broken down into three categories: (1) abstinence/the decision to drink or abstain; (2) the actual amount of alcohol consumed; and (3) heavy drinking. A number of suggestions for human and animal researchers are made in order to address these phenotypes and enhance consilience. Laboratory studies of the decision to drink or to abstain are needed in both human and animal research. In human laboratory studies, heavy or binge drinking that meets cut-offs used in epidemiological and clinical studies should be reported. Greater attention to patterns of drinking over time is needed in both animal and human studies. Individual differences pertaining to all consumption phenotypes should be addressed in animal research. Lastly, improved biomarkers need to be developed in future research for use with both humans and animals. Greater precision in estimating blood alcohol levels in the field, together with consistent measurement of breath/blood alcohol levels in human laboratory and animal studies, provides one means of achieving greater consilience of alcohol consumption phenotypes.

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References

    1. Agrawal A, Grant JD, Littlefield A, Waldron M, Pergadia ML, Lynskey MT, et al. Developing a quantitative measure of alcohol consumption for genomic studies on prospective cohorts. J Stud Alcohol Drugs. 2009;70:157–168. - PMC - PubMed
    1. Allen JP. Measuring outcome in interventions for alcohol dependence and problem drinking: Executive summary of a conference sponsored by the National Institute on Alcohol Abuse and Alcoholism. Alcohol Clin Exp Res. 2003;27:1657–1660. - PubMed
    1. Allen JP, Litten RZ, Strid N, Sillanaukee P. The role of biomarkers in alcoholism medication trials. Alcohol Clin Exp Res. 2001;25:1119–1125. - PubMed
    1. Alte D, Lüdemann J, Piek M, Adam C, Rose HJ, John U. Distribution and dose response of laboratory markers to alcohol consumption in a general population: Results of the Study of Health in Pomerania (SHIP) J Stud Alcohol. 2003;64:75–82. - PubMed
    1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th edition. Washington, DC: American Psychiatric Association; 1994.

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