Long-term neurologic and neurosensory sequelae in adult survivors of a childhood brain tumor: childhood cancer survivor study
- PMID: 12947060
- DOI: 10.1200/JCO.2003.01.202
Long-term neurologic and neurosensory sequelae in adult survivors of a childhood brain tumor: childhood cancer survivor study
Abstract
Purpose: To describe the neurologic and neurosensory deficits in children with brain tumors (BTs), compare incidence of these deficits with that of a sibling control group, and evaluate the factors associated with the development of these deficits.
Patients and methods: Detailed questionnaires were completed on 1,607 patients diagnosed between 1970 and 1986 with a primary CNS tumor. Neurosensory and neurologic dysfunctions were assessed and results compared with those of a sibling control group. Medical records on all patients were abstracted, including radiotherapy dose and volume.
Results: Seventeen percent of patients developed neurosensory impairment. Relative to the sibling comparison group, patients surviving BTs were at elevated risk for hearing impairments (relative risk [RR], 17.3; P = <.0001), legal blindness in one or both eyes (RR, 14.8; P = <.0001), cataracts (RR, 11.9; P = <.0001), and double vision (RR, 8.8; P = <.0001). Radiation exposure greater than 50 Gy to the posterior fossa was associated with a higher likelihood of developing any hearing impairment. Coordination and motor control problems were reported in 49% and 26%, respectively, of survivors. Children receiving at least 50 Gy to the frontal brain regions had a moderately elevated risk for motor problems (RR, 2.0; P <.05). Seizure disorders were reported in 25% of patients, including 6.5% who had a late first occurrence. Radiation dose of 30 Gy or more to any cortical segment of the brain was associated with a two-fold elevated risk for a late seizure disorder.
Conclusion: Children surviving BTs are at significant risk for both early and late neurologic or neurosensory sequelae. These sequelae need to be prospectively monitored.
Similar articles
-
Long-term neurologic health and psychosocial function of adult survivors of childhood medulloblastoma/PNET: a report from the Childhood Cancer Survivor Study.Neuro Oncol. 2017 May 1;19(5):689-698. doi: 10.1093/neuonc/now242. Neuro Oncol. 2017. PMID: 28039368 Free PMC article. Clinical Trial.
-
[Neurosensory, aesthetic and dental late effects of childhood cancer therapy].Bull Cancer. 2015 Jul-Aug;102(7-8):642-7. doi: 10.1016/j.bulcan.2015.04.006. Epub 2015 May 8. Bull Cancer. 2015. PMID: 25962542 Review. French.
-
Late-occurring neurologic sequelae in adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study.J Clin Oncol. 2010 Jan 10;28(2):324-31. doi: 10.1200/JCO.2009.22.5060. Epub 2009 Nov 16. J Clin Oncol. 2010. PMID: 19917844 Free PMC article.
-
Ocular late effects in childhood and adolescent cancer survivors: a report from the childhood cancer survivor study.Pediatr Blood Cancer. 2010 Jan;54(1):103-9. doi: 10.1002/pbc.22277. Pediatr Blood Cancer. 2010. PMID: 19774634 Free PMC article.
-
Cerebrovascular complications and neurodevelopmental sequelae of neonatal ECMO.Clin Perinatol. 1997 Sep;24(3):655-75. Clin Perinatol. 1997. PMID: 9394865 Review.
Cited by
-
White matter connectivity and social functioning in survivors of pediatric brain tumor.J Neurooncol. 2024 Jun 5. doi: 10.1007/s11060-024-04724-0. Online ahead of print. J Neurooncol. 2024. PMID: 38837018
-
Temporal changes in treatment and late mortality and morbidity in adult survivors of childhood glioma: a report from the Childhood Cancer Survivor Study.Nat Cancer. 2024 Apr;5(4):590-600. doi: 10.1038/s43018-024-00733-0. Epub 2024 Mar 1. Nat Cancer. 2024. PMID: 38429413
-
Cognitive deficits and altered functional brain network organization in pediatric brain tumor patients.Brain Imaging Behav. 2023 Dec;17(6):689-701. doi: 10.1007/s11682-023-00798-y. Epub 2023 Sep 11. Brain Imaging Behav. 2023. PMID: 37695507
-
Opportunities and Advances in Radiomics and Radiogenomics for Pediatric Medulloblastoma Tumors.Diagnostics (Basel). 2023 Aug 22;13(17):2727. doi: 10.3390/diagnostics13172727. Diagnostics (Basel). 2023. PMID: 37685265 Free PMC article. Review.
-
Radiotherapy-Induced Neurocognitive Dysfunction in Brain Tumor Survivors: Burden and Rehabilitation.Acta Neurochir Suppl. 2023;130:197-206. doi: 10.1007/978-3-030-12887-6_24. Acta Neurochir Suppl. 2023. PMID: 37548740
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical