Explore Our Portfolio

Search a repository of PCORI-funded comparative clinical effectiveness research (CER) studies, as well as projects that seek to encourage engagement in research, disseminate and implement PCORI-funded research findings, and improve the nation's capacity to conduct patient-centered CER, among others. See the Portfolio User Guide.

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Status Project Status View definitions of the life cycle of an awarded project View Glossary
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
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Health Condition Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Population Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
Year Awarded Year Awarded The year PCORI approved the research study or project for funding. View Glossary
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Displaying 1 - 25 of 47 results

Project Title
Project Status
Funding Type

Delay AvoIding Primary Evaluation for ThRombectomy of Acute StrokE Patients with Large Vessel OCclusion in the Angiography SuiTe (DIRECT) Trial

University of Iowa
| Iowa
Santiago Ortega-Gutierrez, MD
Project Status:
Awarded; Contract pending
Funding Type:
Research

Improving Heterogeneous Effect Estimation by Integration of Experimental and Observational Studies

Vanderbilt University Medical Center
| Tennessee
Amir Asiaeetaheri, Ph.D.
Project Status:
In progress; Recruitment not applicable
Funding Type:
Research, Research Conducted Using PCORnet®

Remote Hypertension Tracking Help and Management to Reduce Disparities in Black Patients (RHYTHM-B)

Wake Forest University Health Sciences
| North Carolina
Yhenneko Taylor, Ph.D., Mstat
Project Status:
In progress; Not yet recruiting
Funding Type:
Research

Improving Outcomes for Patients with Multiple Chronic Conditions Using ECHO

University of New Mexico Health Sciences Center
| New Mexico
Sanjeev Arora, M.D.
Project Status:
In progress; Not yet recruiting
Funding Type:
Research

Improving Cardiovascular Health in Polycystic Ovary Syndrome

University of Pennsylvania Perelman School of Medicine
| Pennsylvania
Anuja Dokras, M.D., Ph.D., MHCI
Project Status:
In progress; Recruitment not applicable
Funding Type:
Research

Transportability of Machine Learning-Enabled Confounding Control Methods Across EHR Databases

Partners Healthcare Brigham and Women's Hospital
| Massachusetts
Richard Wyss, PhD, MS
Project Status:
In progress; Recruitment not applicable
Funding Type:
Research

Treatment with Endovascular Intervention for Stroke Patients with Existing Disability

University of Cincinnati
| Ohio
Eva Mistry, MD, MS
Project Status:
In progress; Recruiting
Funding Type:
Research

Comparing Two Medicines to Treat Coronary Artery Disease in Older Adults -- The LIVE BETTER Trial

Yale University
| Connecticut
Michael Nanna, MD, MHS
Project Status:
In progress; Recruiting
Funding Type:
Research

Comparing Two Ways to Help Patients Control High Blood Pressure

Brody School of Medicine at East Carolina University
| North Carolina
Doyle Cummings, PharmD
Project Status:
In progress; Recruiting
Funding Type:
Research

Comparing Healthcare Visit Recording and Open Notes to Improve the Chronic Illness Care Experience for Older Adults (The CHRONICLE Trial)

Trustees of Dartmouth College
| New Hampshire
Paul Barr, PhD, MPH
Project Status:
In progress; Recruiting
Funding Type:
Research

Comparing Two Ways to Control Blood Pressure after Stroke

Wake Forest University Health Sciences
| North Carolina
Cheryl Bushnell, MD
Project Status:
In progress; Not yet recruiting
Funding Type:
Research, Research Conducted Using PCORnet®

Comparing Medicines to Treat Type 2 Diabetes among Patients with or at High Risk for Heart Disease -- The PRECIDENTD Study

Partners Healthcare Brigham and Women's Hospital
| Massachusetts
Brendan Everett, MD, MPH
Project Status:
In progress; Recruiting
Funding Type:
Research, Research Conducted Using PCORnet®

Comparing Second-Line Medicines to Treat Type 2 Diabetes -- The BESTMED Study

Partners Healthcare Brigham and Women's Hospital
| Massachusetts
Alexander Turchin, MD, MS
Project Status:
In progress; Data collected
Funding Type:
Research, Research Conducted Using PCORnet®

Comparing Two Ways to Help Older Adults Living in Low-Income Housing Maintain Their Health and Independence -- The EPIC Study

Cedars-Sinai
| California
Harriet Aronow, PhD
Project Status:
In progress; Not yet recruiting
Funding Type:
Research
Has Results

Developing New Methods to Identify Topics in Clinical Notes from Electronic Health Records

Brigham and Women's Hospital
| Massachusetts
Alexander Turchin, MD, MS
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Funding Type:
Research, Research Conducted Using PCORnet®

Comparing Two Ways for Hospitals to Help Patients Recover During and After Stroke

Vanderbilt University Medical Center
| Tennessee
Kenneth Gaines, MD, MBA
Project Status:
In progress; Data collected
Funding Type:
Research, Research Conducted Using PCORnet®

What Is the Effect of Adding a Health Coach to Patient-Centered Medical Homes for Managing Multiple Chronic Conditions?

Clinical Directors Network
| New York
Jonathan Tobin, PhD
Project Status:
In progress; Enrollment complete
Funding Type:
Research, Research Conducted Using PCORnet®
Has Results

Stroke Prevention in Atrial Fibrillation Patients: A Systematic Review Update

Memorandum of Understanding with Agency for Healthcare Research and Quality (AHRQ)
| Maryland
Project Status:
Completed
Funding Type:
Research

Community Health Worker and Mobile Health Programs to Help Young Adults with Sickle Cell Disease Transition to Using Adult Healthcare Services -- The COMETS Study

The Childrens' Hospital of Philadelphia
| Pennsylvania
Tanisha Belton, DrPh, MPH
Project Status:
In progress; Enrollment complete
Funding Type:
Research
Has Results

Comparing Two Ways to Provide Advance Care Planning in Primary Care Clinics to Patients with a Serious Illness

Oregon Health & Science University
| Oregon
Annette M. Totten, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Funding Type:
Research
Has Results

Developing New Methods for Comparing Treatments in Case-Control Studies

Harvard T.H. Chan School of Public Health
| Massachusetts
Goodarz Danaei, MD, MS, DSc
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Funding Type:
Research
Has Results

Understanding How Patients' Response to Treatment Varies Using Predicted Risk

Tufts Medical Center, Inc.
| Massachusetts
David Kent, MD, MS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Funding Type:
Research
Has Results

Using Different Data Sets to Test How Well Clinical Prediction Models Work to Predict Patients' Risk of Heart Disease

Tufts Medical Center
| Massachusetts
David M. Kent, MD, MS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Funding Type:
Research
Has Results

Comparison of Early versus Standard Timing of Tracheostomy in Patients with Severe Stroke and Breathing Failure -- The SETPOINT 2 Study

Maine Medical Center
| Maine
David B. Seder, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Funding Type:
Research
Has Results

Comparing Mobile Stroke Unit Treatment with Emergency Room Care among Patients Who Have Had a Stroke -- The BEST-MSU Study

Memorial Hermann-Texas Medical Center
| Texas
James Grotta, MD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Funding Type:
Research

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