Systematic Review on Polyphenol Intake and Health Outcomes: Is there Sufficient Evidence to Define a Health-Promoting Polyphenol-Rich Dietary Pattern?
- PMID: 31208133
- PMCID: PMC6627994
- DOI: 10.3390/nu11061355
Systematic Review on Polyphenol Intake and Health Outcomes: Is there Sufficient Evidence to Define a Health-Promoting Polyphenol-Rich Dietary Pattern?
Abstract
Growing evidence support association between polyphenol intake and reduced risk for chronic diseases, even if there is a broad debate about the effective amount of polyphenols able to exert such protective effect. The present systematic review provides an overview of the last 10-year literature on the evaluation of polyphenol intake and its association with specific disease markers and/or endpoints. An estimation of the mean total polyphenol intake has been performed despite the large heterogeneity of data reviewed. In addition, the contribution of dietary sources was considered, suggesting tea, coffee, red wine, fruit and vegetables as the main products providing polyphenols. Total flavonoids and specific subclasses, but not total polyphenols, have been apparently associated with a low risk of diabetes, cardiovascular events and all-cause mortality. However, large variability in terms of methods for the evaluation and quantification of polyphenol intake, markers and endpoints considered, makes it still difficult to establish an evidence-based reference intake for the whole class and subclass of compounds. Nevertheless, the critical mass of data available seem to strongly suggest the protective effect of a polyphenol-rich dietary pattern even if further well targeted and methodologically sound research should be encouraged in order to define specific recommendations.
Keywords: cardiovascular and all-cause mortality; dietary pattern; disease risk; polyphenol databases; polyphenol intake.
Conflict of interest statement
The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
Figures
![Figure 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/6627994/bin/nutrients-11-01355-g001.gif)
![Figure 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/6627994/bin/nutrients-11-01355-g002.gif)
![Figure 3](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/6627994/bin/nutrients-11-01355-g003.gif)
![Figure 4](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/6627994/bin/nutrients-11-01355-g004.gif)
![Figure 5](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/6627994/bin/nutrients-11-01355-g005.gif)
![Figure 6](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/6627994/bin/nutrients-11-01355-g006.gif)
Similar articles
-
Dietary Polyphenols: What is the Estimated Intake in Population Studies With Adults and Elderly People?Curr Nutr Rep. 2024 Jun;13(2):280-293. doi: 10.1007/s13668-024-00530-2. Epub 2024 Apr 5. Curr Nutr Rep. 2024. PMID: 38578590 Review.
-
Dietary intake of polyphenols and major food sources in an institutionalised elderly population.J Hum Nutr Diet. 2014 Apr;27(2):176-83. doi: 10.1111/jhn.12058. Epub 2013 Mar 24. J Hum Nutr Diet. 2014. PMID: 23521491
-
Adherence to UK dietary guidelines is associated with higher dietary intake of total and specific polyphenols compared with a traditional UK diet: further analysis of data from the Cardiovascular risk REduction Study: Supported by an Integrated Dietary Approach (CRESSIDA) randomised controlled trial.Br J Nutr. 2019 Feb;121(4):402-415. doi: 10.1017/S0007114518003409. Br J Nutr. 2019. PMID: 30760336 Clinical Trial.
-
Dietary intake and food contributors of polyphenols in adults and elderly adults of Sao Paulo: a population-based study.Br J Nutr. 2016 Mar 28;115(6):1061-70. doi: 10.1017/S0007114515005061. Epub 2016 Jan 26. Br J Nutr. 2016. PMID: 26810764
-
A systematic review of food composition tools used for determining dietary polyphenol intake in estimated intake studies.Food Chem. 2018 Jan 1;238:146-152. doi: 10.1016/j.foodchem.2016.11.010. Epub 2016 Nov 3. Food Chem. 2018. PMID: 28867085 Review.
Cited by
-
Beneficial Effects of Manilkara zapota-Derived Bioactive Compounds in the Epigenetic Program of Neurodevelopment.Nutrients. 2024 Jul 11;16(14):2225. doi: 10.3390/nu16142225. Nutrients. 2024. PMID: 39064669 Free PMC article. Review.
-
Encapsulation of W/O/W Acerola Emulsion by Spray Drying: Optimization, Release Kinetics, and Storage Stability.Foods. 2024 May 9;13(10):1463. doi: 10.3390/foods13101463. Foods. 2024. PMID: 38790764 Free PMC article.
-
Targeted Anthocyanin Enrichment of Cranberry Juice by Electrodialysis with Filtration Membranes: Impact of Filtration Membrane Physicochemical Properties and Predictive Statistical Models.Membranes (Basel). 2024 May 14;14(5):111. doi: 10.3390/membranes14050111. Membranes (Basel). 2024. PMID: 38786945 Free PMC article.
-
Dietary Polyphenols: What is the Estimated Intake in Population Studies With Adults and Elderly People?Curr Nutr Rep. 2024 Jun;13(2):280-293. doi: 10.1007/s13668-024-00530-2. Epub 2024 Apr 5. Curr Nutr Rep. 2024. PMID: 38578590 Review.
-
The effects of flavonoid supplementation on the mental health of postpartum parents.Front Glob Womens Health. 2024 Mar 20;5:1345353. doi: 10.3389/fgwh.2024.1345353. eCollection 2024. Front Glob Womens Health. 2024. PMID: 38577523 Free PMC article.
References
-
- Chong P.Y.Y., Ho S.C., Kreiger N., Murphy P.A., So E.K.F., Chan S.G., Darlington G. Isoflavonoid content of Hong Kong soy foods. J. Agric. Food Chem. 2009;57:5386–5390. - PubMed
-
- Cherniack E.P. Polyphenols and Aging. Mol. Basis Nutr. Aging Vol. Mol. Nutr. Ser. 2016;3:649–657.